Does trazodone cause side effects? (+5 serious side effects)

 In this article, we will discuss both the serious and mild side effects caused by trazodone. Additionally, we will explore research studies demonstrating the side effects associated with the use of trazodone in individuals. We will also discuss alternatives to trazodone if it causes serious side effects.

Does trazodone cause side effects?

Yes, trazodone does cause side effects. Although it is considered a safe medication for the long-term management of various mental disorders, it can have side effects in individuals. The side effects of trazodone may range from mild to serious.

The occurrence of these side effects may depend on the individual’s response to trazodone as well as their overall health status. Side effects are commonly reported during the initial stage of treatment as the body adjusts to trazodone, and they may subside eventually after the body adapts to the medication (1).

However, some individuals may experience serious and life-threatening side effects of this medication, such as serotonin syndrome, which can lead to severe consequences such as coma and death (1).

What are the serious side effects of trazodone?

While the serious side effects caused by this medication are rare and uncommon, these side effects may occur in some individuals based on their sensitivity to the medication or underlying health conditions. Some of the serious side effects that can be caused by trazodone include the following:

• cardiovascular complications 
• parkinsonism
• serotonin syndrome
• priapism
• hallucinations

 It is important to know that not everyone who takes this medication will experience all of these side effects. However, if you experience any of these side effects, it is essential to consult your healthcare provider as soon as possible.

What are the mild side effects of trazodone?

Trazodone may cause some mild side effects, which are common and often occur in the initial phases when the patient is new to the medication. However, they may gradually subside as the body adjusts to the medication. Some of the common side effects associated with trazodone may include the following: 

• dizziness
• drowsiness
• sleep disturbances
• nausea
• fatigue
• sedation
• dry mouth
• hypotension
• vertigo
• irritability
• nightmares
• agitation
• headache 
• appetite changes
• weight changes

You should not worry if you experience these side effects, as they often improve with time. However, if the side effects persist, you should consult your healthcare provider immediately.

What does research suggest?

According to research, trazodone is considered a safe medication with a lower risk of serious side effects even at higher dosages. Most individuals taking this medication may generally report mild to moderate side effects.

In a research study, trazodone was used to treat depression in individuals at a dosage of around 300 mg for a period of 2 months. The reported side effects were present in more than 5% of the individuals, with the most commonly reported side effects being xerostomia, nausea, dizziness, fatigue, headache, and drowsiness (2).

In a research study, a patient undergoing treatment with trazodone for insomnia and sleep disturbances reported an uncommon side effect, parkinsonism, emerging after a few weeks of treatment (3).

Additionally, another study noted the occurrence of priapism at a lower dosage, around 150 mg per day, of trazodone, following one month of use. It’s crucial to highlight that while these side effects are rare, they may manifest in some individuals (4).

What to do if trazodone causes serious side effects? 

If you experience mild to moderate side effects of trazodone, you should not worry, as these symptoms may subside over time. However, if you encounter persistent and severe side effects after taking this medication, you should consult your healthcare provider immediately. They can assess your condition and determine the actual cause of your symptoms.

In case of mild side effects of trazodone, they may be treated symptomatically with over-the-counter medications. For example, analgesics can be used for headaches and fatigue, while anti-diarrheal can help with diarrhea.

Your provider may recommend adjustments to the treatment plan, including dosage adjustments or even discontinuation of the medication, depending on the severity of the symptoms. Dosage adjustment is often beneficial in many cases.

However, if the symptoms persist, discontinuation of the medication may be recommended.  It’s crucial to be vigilant about your symptoms and not abruptly stop taking this medication, as sudden discontinuation can lead to withdrawal effects that may worsen your condition.

Your healthcare provider may prescribe alternative medications to trazodone that are as effective but have a lower incidence of serious side effects. Examples of such alternatives include fluoxetine, duloxetine, and citalopram. However, it’s important not to make a decision to change or switch your medication without consulting your healthcare provider.

In my opinion, while this medication is considered safe, it may cause side effects in individuals. You should always remain aware of any unusual symptoms that may occur after using this medication and report them to your healthcare provider as soon as possible to avoid any unwanted and serious consequences.

References