Does Trazodone cause joint pain? 

Does Trazodone cause joint pain? 

Trazodone does not commonly cause joint pain, but it is listed as a side effect of this antidepressant. Trazodone affects people differently, and most of them don’t really complain of joint pain. 

The drug does not damage your bones or affect the formation of bone cells. However, long-term users of Trazodone may complain of joint or muscle pain

If you’re new to this antidepressant and you feel pain in your joints, this could be an early side effect of Trazodone and will most likely fade away within a few weeks, as your body adjusts to the medication. 

What does research suggest?

There is limited research on joint pain caused by Trazodone and the incidence of this effect is quite low. Very few cases of joint pain have been reported so far. Trazodone is actually known for providing relief in fibromyalgia (1). 

It may not be the best choice of medication for that and there are better options out there, but Trazodone can improve the quality of life in patients with fibromyalgia.  

However, researchers have also indicated that people are different and can respond differently to medications. Some people may experience less common or rare side effects of Trazodone.

What to do if Trazodone causes joint pain?

It’s best to talk to your healthcare provider if Trazodone causes joint pain. Although it is unlikely for this antidepressant to significantly affect your bones, people can respond differently. 

If for some reason, Trazodone is affecting your bone health or the synovial fluid which cushions your joints and prevents friction while you move them, your doctor will switch you to another antidepressant. 

Make sure you don’t make any changes to your prescription on your own. If your doctor believes that Trazodone is the actual culprit and there is no other factor that could contribute to your joint pain, he/she will gradually start decreasing your dose. 

Antidepressants are never stopped abruptly, as they can cause disturbing symptoms associated with an antidepressant withdrawal syndrome. This is why it’s important to consult your doctor and follow the directions properly. 

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Morillas-Arques P, Rodriguez-Lopez CM, Molina-Barea R, Rico-Villademoros F, Calandre EP. Trazodone for the treatment of fibromyalgia: an open-label, 12-week study. BMC Musculoskelet Disord. 2010 Sep 10;11:204. doi: 10.1186/1471-2474-11-204. PMID: 20831796; PMCID: PMC2945951. Available from:

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