Does trazodone cause drowsiness? (+5 factors)

 In this article, we will discuss whether trazodone causes drowsiness. We will also explore research studies suggesting a link between the use of trazodone and the occurrence of drowsiness. Additionally, we will discuss the risk factors that may increase the likelihood of trazodone-induced drowsiness, as well as the management tips for trazodone-induced drowsiness.

Does trazodone cause drowsiness?

Yes, trazodone does cause drowsiness. It is a common side effect associated with the use of antidepressant medications, including trazodone. While it is generally considered a safe medication, it may cause some mild to moderate side effects in the initial phase of treatment, including dizziness and drowsiness (2).

Other side effects that may occur with trazodone include nausea, vomiting, fatigue, headache, and dry mouth. Therapeutic uses of this medication may include its use in managing depression, anxiety, post-traumatic stress disorders, chronic pain, and fibromyalgia.

What does research suggest?

According to research, trazodone is a safe medication with a lower incidence of serious and life-threatening side effects (2).

Drowsiness is commonly associated with the use of this medication, which is generally mild and helpful in cases where individuals taking this medication have sleep disturbances and insomnia, along with other mental disorders such as depression or anxiety. The sedative effects of trazodone include sleepiness in these patients (1).

According to the Food and Drug Administration (FDA), over 20% of hospitalized patients on trazodone reported experiencing drowsiness, while more than 40% of outpatient individuals reported both dizziness and drowsiness after taking this medication (3).

What factors can influence trazodone-induced drowsiness? 

There are several factors that may increase the risk of trazodone-induced drowsiness. These factors may vary from one individual to another, and the presence of these factors influences the likelihood of various side effects of trazodone, including drowsiness. These factors may include:

Individual sensitivity: Individual sensitivity to trazodone may increase the risk of various side effects, including dizziness and other side effects that rarely occur in some individuals, such as cardiovascular complications and sexual side effects.

Concurrent medications: The concurrent use of trazodone with other antidepressant medications, such as mirtazapine, and tricyclic antidepressant medication, increases drowsiness in individuals, potentially affecting their daily activities.

Medical conditions: Individuals with underlying medical conditions, such as central nervous system disorders, electrolyte imbalances, diabetes, and sleeping disorders, also increase the risk of experiencing excessive drowsiness while taking this medication. 

Dosage: A higher dosage of trazodone is associated with a higher risk of causing serious and persistent side effects, including prolonged drowsiness.

Start of treatment: During the initial phase of treatment, there is a higher risk of experiencing side effects with antidepressant medications, including trazodone. During this period, the body is adjusting to the medication, and various side effects, including dizziness, drowsiness, and nausea, are commonly observed.

What to do if trazodone causes drowsiness?

Experiencing drowsiness during the initial phase of treatment does not usually cause any serious issues. However, if you experience severe and persistent drowsiness and sedation after starting this medication, you should consult your healthcare provider as soon as possible.

They will assess your condition and determine the cause of your symptoms. If trazodone is causing side effects that are affecting your quality of life, they may recommend changes to your treatment plan and may suggest a dosage adjustment of trazodone or complete discontinuation, based on the severity of your symptoms.

The discontinuation of trazodone should be done gradually to avoid unwanted side effects that may occur due to the sudden discontinuation of the medication. Your healthcare provider may prescribe an alternative medication that is less likely to cause drowsiness for treating the condition for which trazodone was prescribed.

What are the management tips for trazodone-induced drowsiness?

Managing drowsiness induced by trazodone involves addressing the medication’s specific factors and making lifestyle adjustments to enhance wakefulness and alertness. To mitigate trazodone-induced drowsiness, consider these specific strategies:

• Maintain a consistent sleep schedule by going to bed and waking up at the same time every day.

• Dehydration can exacerbate trazodone-induced drowsiness, so ensure you drink enough water throughout the day to stay well-hydrated and avoid unwanted effects.

• Consume a well-balanced diet with a mix of proteins and healthy carbs while avoiding heavy meals that can cause post-meal drowsiness.

• Engage in regular physical activity, as it can improve overall energy levels and reduce feelings of fatigue.

• Limit sugary foods and drinks that may cause energy fluctuations and practice stress-reducing techniques to prevent stress-related fatigue and subsequent drowsiness. 

What are the alternatives to trazodone if it causes drowsiness?

Drowsiness with trazodone usually subsides when the body adjusts to the medication. However, during this period, if you experience severe drowsiness that is impacting your daily activities, your healthcare provider may recommend alternative medications that are less likely to cause drowsiness. These medications may include:

• sertraline
• duloxetine
• paroxetine
• bupropion
• fluoxetine

 While these medications might have a lower risk of causing drowsiness compared to trazodone, they can still cause drowsiness in some individuals based on their response to the medication.

It is important to consult with your healthcare provider if you experience any unwanted symptoms after taking these medications to ensure the safety and effectiveness of the treatment.

In my opinion, drowsiness induced by trazodone usually subsides on its own in most cases and may not necessitate a change in the treatment plan. However, in the case of severe and resistant drowsiness, your healthcare provider may recommend alterations.

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