Does trazodone cause bradycardia? (+5 factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether trazodone causes bradycardia. We will also explore the research studies linking the effects of trazodone to bradycardia, as well as the factors that may increase the risk of bradycardia with trazodone. Additionally, we will discuss the management tips for trazodone-induced bradycardia.
Does trazodone cause bradycardia?
Yes, trazodone may cause bradycardia. However, some research studies have also reported cases where individuals experienced tachycardia with trazodone. The incidence of cardiovascular side effects of trazodone is generally low, but some individuals may report these issues after taking this medication.
Generally, trazodone is an antidepressant medication that is employed in the management of various health conditions, including depression, anxiety, fibromyalgia, and chronic pain. The common side effects of this medication may include nausea, vomiting, dizziness, headache, nightmares, fatigue, drowsiness, and dry mouth (1).
What does research suggest?
According to research, bradycardia induced by trazodone is a reported side effect of the medication. However, the Food and Drug Administration has demonstrated that the incidence of trazodone-induced bradycardia is very low, and it may occur when trazodone is used for an extended period (2).
A research study documented the occurrence of trazodone-induced bradycardia in an individual using the medication for the management of underlying depression. Interestingly, the patient reported bradycardia after taking a single dose of trazodone, and the symptoms subsided after discontinuation of the medication (3).
In another study, an individual reported bradycardia and other side effects of trazodone within an hour of taking the medication. However, it’s worth noting that in this case, the patient was concurrently taking clonidine as well (4).
What factors may influence trazodone-induced bradycardia?
Several factors may increase the risk of trazodone-induced bradycardia. These factors may include:
Concurrent Medications: Concurrent use of other medications known to have bradycardia as a side effect can amplify the risk. As observed in research studies, the concurrent use of trazodone and clonidine, a medication with cardiovascular effects, can contribute to bradycardia (4).
Pre-existing Cardiac Conditions: Individuals with underlying cardiovascular conditions may have an increased vulnerability to trazodone-induced bradycardia.
Longer Duration: Prolonged use of trazodone has been associated with an increased risk of bradycardia. Monitoring individuals on trazodone for an extended period is essential.
Higher Dosage: The risk of trazodone-induced bradycardia may be higher in individuals who take elevated doses of the medication. Adjusting the dosage should be done cautiously under medical supervision.
Lifestyle: Factors such as an individual’s overall health and lifestyle can also play a role. Conditions or habits that affect cardiovascular health may contribute to an elevated risk.
What to do if trazodone causes bradycardia?
While the incidence of serious bradycardia is relatively low with trazodone, it is essential to be vigilant if you observe signs or symptoms of bradycardia while using this medication, such as a slow heart rate. In such instances, it is crucial to consult your healthcare provider as soon as possible.
Your healthcare provider will conduct a thorough assessment to determine the cause of your symptoms and may make adjustments to your treatment plan accordingly.
It is imperative not to alter your medication regimen, including discontinuing trazodone, without seeking guidance from your healthcare provider. Abruptly stopping medication can have adverse effects, and any changes should be made under the supervision of a healthcare professional.
During your communication with healthcare professionals, provide detailed information about your symptoms and any other relevant health concerns. Your healthcare provider will likely conduct a thorough evaluation to determine the cause of the bradycardia and assess whether it is linked to trazodone use or other factors.
How to manage trazodone-induced bradycardia?
For the effective management of trazodone-induced bradycardia, your healthcare provider may recommend lifestyle modifications, including mild exercises, and advise avoiding alcohol and nicotine consumption, which can exacerbate your symptoms.
Depending on the severity of your symptoms, your healthcare provider may suggest medications to increase your heart rate. Examples of such medications include Atropine and Epinephrine.
Moreover, if bradycardia is a result of an underlying medical condition or medication, addressing the root cause is crucial. Your healthcare provider will work to identify and address any risk factors contributing to bradycardia.
In cases where trazodone-induced bradycardia leads to fainting or other serious symptoms, emergency measures such as cardiopulmonary resuscitation (CPR) may be employed.
In my opinion, trazodone has been associated with reports of bradycardia; however, this tends to resolve gradually as the body adapts to the medication. Any modifications to the treatment plan, including adjustments in trazodone dosage or the introduction of supplementary medications, should be undertaken exclusively under the guidance and oversight of your healthcare provider.
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References
1.-
Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470560/
3.-
Li TC, Chiu HW, Ho KJ, Tzeng DS. Bradycardia following a single low dose of trazodone. Asian J Psychiatr. 2011 Mar;4(1):77-9. doi: 10.1016/j.ajp.2010.03.003. Epub 2011 Mar 2. PMID: 23050923. https://pubmed.ncbi.nlm.nih.gov/23050923/
4.-
Bhatara VS, Kallepalli BR, Misra LK, Awadallah S. A possible clonidine-trazodone-dextroamphetamine interaction in a 12-year-old boy. J Child Adolesc Psychopharmacol. 1996 Fall;6(3):203-9. doi: 10.1089/cap.1996.6.203. PMID: 9231313. https://pubmed.ncbi.nlm.nih.gov/9231313/
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