Does trazodone affect urination? (+5 factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether trazodone affects urination. We will also explore the factors that may increase the risk of trazodone-induced urinary problems, as well as research studies providing evidence of this side effect of trazodone.
Does trazodone affect urination?
Yes, trazodone does affect urination. It may lead to urinary retention or urinary incontinence in some individuals who take this medication. However, it is not frequently reported as a side effect compared to other side effects such as nausea, vomiting, dizziness, drowsiness, headache, fatigue, dry mouth, and insomnia.
Trazodone is an antidepressant medication commonly used in the management of various health conditions, including depression, anxiety, fibromyalgia, and pain. Additionally, it is useful in patients with underlying obsessive-compulsive disorders and post-traumatic stress disorder (1).
What does research suggest?
According to research, the risk of urinary problems, such as urinary retention, is less commonly associated with trazodone; however, some individuals may experience this issue (2).
A research study reported a case in which a patient who administered a high dosage of trazodone for the management of underlying depression experienced severe drowsiness, loss of coordination, cardiovascular side effects, and urinary retention all within hours after taking this medication (3).
In another study, an elderly female patient reported severe urinary incontinence after taking a low dose of trazodone at 50mg daily for a few days. She had been taking trazodone for managing underlying mental disorders and insomnia, with no history of urinary incontinence. The patient discontinued the medication due to the reported urinary incontinence (4).
What factors may influence trazodone-induced urinary problems?
Various factors may increase the risk of experiencing urinary problems with trazodone. These factors may include:
Individual sensitivity to trazodone: The degree of an individual’s sensitivity to trazodone can contribute to the likelihood of urinary issues. Some patients are more susceptible to experiencing the uncommon side effects of trazodone, including urinary retention.
Concurrent use of medications: The simultaneous use of medications with trazodone can also cause urinary retention. For example, sympathomimetic medications can increase the risk of urinary retention when used alongside trazodone.
Underlying medical conditions: Certain medical conditions, such as prostate enlargement in males, can increase the risk of urinary retention or incontinence in patients taking trazodone to manage their mental health disorders or any other condition.
Dosage of trazodone: Higher dosages of trazodone are associated with a higher risk of experiencing less common side effects, including urinary retention. Research studies have provided evidence linking higher dosages of trazodone with serious urinary issues, including prolonged urinary retention.
Age: Advanced age can be an additional factor influencing the risk of urinary problems with trazodone. The use of trazodone in elderly patients may cause uncommon side effects, as they are physically and physiologically weaker than younger adults.
What to do if trazodone affects urination?
Urinary problems are not common with trazodone; however, if you experience symptoms of urinary retention, such as abdominal pain or difficulty emptying your bladder with a sudden urge to urinate again after urination, you should consult your healthcare provider.
These side effects are more prevalent during the initial phase of treatment or due to the high dosage of trazodone. Your healthcare provider may assess your condition and make changes to your treatment plan, either by reducing the dosage of trazodone or discontinuing the medication altogether. However, discontinuation should be done gradually to avoid unwanted withdrawal symptoms.
Your healthcare provider may recommend an alternative to trazodone for managing your mental health that is less likely to cause urinary problems. These medications may include duloxetine, imipramine, and escitalopram. The choice of a suitable medication should be based on the patient’s individual condition and overall health.
How to manage trazodone-induced urinary problems?
The management of trazodone-induced urinary problems, including urinary retention or incontinence, may involve a combination of pharmacological and non-pharmacological approaches.
Pharmacological approaches may include the use of medications like tamsulosin and alfuzosin, which relax smooth muscles to improve urine flow.
Additionally, oxybutynin can be used to enhance overall bladder function, and mirabegron for the effective management of an overactive bladder. However, It’s crucial to note that your healthcare provider should make the selection of an appropriate medication based on your individual symptoms to prevent unwanted side effects.
Non-pharmacological approaches may involve:
- catheterization, to relieve immediate pressure on the bladder by draining urine
- lifestyle adjustments, such as daily exercises like pelvic floor exercises, that can strengthen the bladder
- adequate fluid intake, as dehydration, can exacerbate symptoms
- stress-reducing exercises, that may contribute to overall health
In my opinion, urinary problems with trazodone are less common. However, if you experience any symptoms related to urination, it is advisable to consult your healthcare provider for an accurate diagnosis and personalized treatment plan.
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References
1.-
Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470560/
2.-
Cuomo A, Ballerini A, Bruni AC, Decina P, Di Sciascio G, Fiorentini A, Scaglione F, Vampini C, Fagiolini A. Clinical guidance for the use of trazodone in major depressive disorder and concomitant conditions: pharmacology and clinical practice. Riv Psichiatr. 2019 Jul-Aug;54(4):137-149. doi: 10.1708/3202.31796. PMID: 31379379. https://pubmed.ncbi.nlm.nih.gov/31379379/
3.-
Mohan G, Ajitkumar A, Bhide P, Ravilla J, Kramer V. Trazodone Overdose Manifesting as Hypotension and QT Prolongation. Cureus. 2023 Mar 29;15(3):e36871. doi: 10.7759/cureus.36871. PMID: 37123743; PMCID: PMC10147490. https://pubmed.ncbi.nlm.nih.gov/37123743/
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