Does trazodone affect birth control? (6+ safety measures)

In this article, we will discuss whether trazodone affects birth control, what research suggests, what factors can contribute to trazodone affecting birth control, what to do if trazodone affects birth control, and how to ensure the safe use of birth control.

Does trazodone affect birth control?

No, trazodone does not affect birth control. There is no clear evidence suggesting that trazodone has any effect on birth control methods. Trazodone is an antidepressant that belongs to the serotonin-antagonist reuptake inhibitor (SARI). It is mainly prescribed for the treatment of major depressive disorders, anxiety and insomnia.  (1)

Whereas birth control methods are designed to avoid pregnancy. This can be done by physical blocking of the passage or hormonal imbalance, which alters the menstrual cycle and prevents pregnancy. Birth controls involve oral contraceptive pills, intrauterine devices (IUDs), vaginal contraceptives, etc. (2)

Trazodone affects serotonin levels in the brain and does not interfere with contraceptives in any way.

What does research suggest?

Studies on the investigation of the potential interaction between trazodone and birth control are limited, and findings are inconclusive. It is important to stay vigilant when taking birth control and trazodone together to avoid any unwanted consequences.

One research study indicates that trazodone has no known impact on the effectiveness of hormonal contraceptives, such as birth control pills, and there is no data on the efficacy of non-oral hormonal contraceptives, such as patches or IUDs. (3)

However, it is crucial to note that individual responses to medications can vary, and more research is needed to establish a definitive conclusion.

What factors can affect birth control while taking Trazodone?

Various factors can contribute to the potential interaction between trazodone and birth control.

  • Other medications: Use of birth control and trazodone while taking other medications can cause additional interactions and affect birth control.


  • Underlying health issues: Underlying health conditions that affect the liver and metabolism may impact birth control. The CYP3A4 enzyme in the liver metabolises trazodone and oral contraceptives. Changes in this enzyme’s activity can affect the metabolism of both trazodone and birth control hormones, potentially influencing their effectiveness.


  • Individual differences: Individual metabolism and genetics may contribute to the variability in how trazodone interacts with birth control.

If you experience any unwanted symptoms, do not stop taking trazodone or your birth control on your own. Contact your healthcare provider for better management of the symptoms.

What to do if trazodone affects birth control?

If you are taking trazodone along with birth control and suspect an interaction, it is essential that you consult with your healthcare provider promptly.

  • Do not make any adjustments to your medications without consulting your doctor.
  • Your healthcare provider will assess your health profile, medication history, and any potential risk factors affecting your birth control. 
  • Your healthcare provider might consider lowering the dose, as there are no known interactions between trazodone and contraceptives.
  • If your healthcare provider thinks that trazodone is disrupting your hormonal balance, he may consider other antidepressants or determine the most appropriate course of action for you.

How to ensure safe use of birth control while taking trazodone?

To ensure the safe use of birth control while taking trazodone, consider the following:

  • Open communication: Inform your healthcare provider about all medications, prescriptions, over-the-counter drugs and supplements to help them make informed decisions about your health.


  • Timing of medication: Ensure that you take birth control at the same time every day to increase its efficacy. Avoid taking trazodone and birth control at the same time to avoid any interaction.



  • Regular check-ups: Schedule check-ups to monitor your overall health, as this allows healthcare providers to identify any issues promptly.


  • Stay consistent: Do not miss a dose of your birth control. Set an alarm if you have to to avoid any complications.


  • Avoid smoking: Smoking while on birth control can be very dangerous, so avoid it at all costs. (4)


  • Alternative contraceptive methods: If concerns persist, discuss alternative contraceptive methods that may not be affected by trazodone.


In my opinion, the impact of trazodone on birth control is not entirely clear, so it is essential for individuals taking both medications to stay vigilant and communicate openly with their healthcare providers.

Further research is needed to establish conclusive evidence on this interaction. In the meantime, proactive discussions with healthcare professionals can help individuals make informed decisions about their mental health and contraceptive needs.

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Shin JJ, Saadabadi A. Trazodone. [Updated 2022 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Hatcher RA, Kowal D. Birth Control. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 174. Available from:


Berry-Bibee EN, Kim MJ, Simmons KB, Tepper NK, Riley HE, Pagano HP, Curtis KM. Drug interactions between hormonal contraceptives and psychotropic drugs: a systematic review. Contraception. 2016 Dec;94(6):650-667. doi: 10.1016/j.contraception.2016.07.011. Epub 2016 Jul 18. PMID: 27444984.


Cooper DB, Patel P, Mahdy H. Oral Contraceptive Pills. [Updated 2022 Nov 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:

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