Does Tizanidine contain Aspirin? 

Does Tizanidine contain Aspirin? 

No, Tizanidine does not contain Aspirin. They both are different medications, work in different ways, and have different side effects profiles. Tizanidine is a muscle relaxant, whereas Aspirin is an over-the-counter non-steroidal anti-inflammatory drug (NSAID). 

How is Tizanidine different from Aspirin? 

Tizanidine is different from Aspirin in a number of ways: 

Mechanism of action and clinical efficacy

Tizanidine is used to relax your muscles and control involuntary muscle spasms and stiffness. This helps relieve pain and other symptoms. Tizanidine can also be used for the management of pain and tightness associated with a muscle injury or multiple sclerosis(1)

It basically slows down muscle contraction by inhibiting the action in your brain, and it does not affect the muscle directly. Tizanidine is a prescription medication, so don’t take it without your doctor’s approval. 

Aspirin, on the other hand, is an OTC medication used for the management of pain, fever, and inflammation. It can also be used as a blood thinner in patients with coronary artery diseases or those who are generally at high risk of cardiac diseases(2).

Aspirin basically inhibits Prostaglandin synthesis, which is an important mediator of pain and inflammation. 

Side effect profiles

Tizanidine, although it is a well-tolerated medication, is associated with some side effects. 

Common side effects of Tizanidine

  • Weakness 
  • Sleepiness 
  • Dizziness 
  • Depression 
  • Nausea 
  • Vomiting 
  • Diarrhoea 
  • Nervousness 
  • Tingling sensation 
  • Dry mouth
  • Stomach pain
  • Acid reflux 

Serious and rare side effects of Tizanidine

  • An allergic reaction 
  • Bleeding 
  • Extreme fatigue and weakness 
  • Severe Abdominal pain
  • Flu-like symptoms 
  • Low heart rate
  • Weight gain
  • Vision changes

These side effects can vary from person to person and should be reported right away. Not every medication works well for everyone. If Tizanidine is negatively affecting your body, it shouldn’t be continued. 

Aspirin, on the other hand, is an OTC medication that works well, but some people can’t tolerate this medication. 

Common side effects of Aspirin

  • Nausea
  • Vomiting 
  • Abdominal pain
  • Acid reflux 
  • Flatulence 

Rare and serious side effects of Aspirin

  • An allergic reaction or hypersensitivity 
  • Arrhythmia or abnormal heartbeat
  • Irregular breathing 
  • Tremors 
  • Bloody vomiting 
  • Loss of hearing
  • Black or tarry stools – indicating gastrointestinal bleeding
  • Ulceration

Can Tizanidine be taken with Aspirin?

It’s best to talk to your healthcare provider before taking Tizanidine and Aspirin together. Since the meds are entirely different, you can use one as an alternative to another. 

Tizanidine and Aspirin may interact with one another and cause disturbing side effects like bleeding and stomach problems. People who are already taking Aspirin regularly for other health conditions should inform their healthcare provider before taking Tizanidine. 

It is important to follow the prescribed dosage of both medications and to seek medical attention immediately if any adverse reactions occur.

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PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 5487, Tizanidine; [cited 2023 Mar. 04]. Available from:


PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 2244, Aspirin; [cited 2023 Mar. 04]. Available from: