Does Sertraline Drowsiness improve? (3+ Factors)

This article will discuss the topic of drowsiness associated with sertraline. It will explore the factors that influence the duration and severity of sertraline-induced drowsiness, as well as the potential impact on sleep patterns.

Additionally, the article will provide insights into managing and mitigating drowsiness for individuals taking sertraline, including various strategies and considerations to improve overall well-being and minimize the impact of this side effect. 

Does sertraline drowsiness improve?

Drowsiness associated with sertraline will gradually improve within the first few weeks of starting the medication. However, it is essential to remember that everyone’s response to medications differs, and some patients may experience drowsiness for more extended periods [1] [2]

Moreover, individual factors such as the dosage, overall health, and metabolism can influence how long the drowsiness persists. Patience is necessary while adjusting to sertraline, and it is advisable to consult a healthcare professional if the drowsiness becomes bothersome or remains for an extended duration.

What does research suggest?

Research reveals that antidepressants have a significant impact on sleep patterns, including the specific alteration of rapid eye movement (REM) sleep. These changes lead to shorter duration and delayed onset of REM sleep [4] [3]. 

As a consequence, individuals may encounter difficulties falling asleep, experience disrupted sleep patterns, and observe a reduction in overall REM sleep time. This can result in inadequate recovery and persistent fatigue and drowsiness throughout the day. 

Notably, the effect on REM sleep is more pronounced in selective serotonin reuptake inhibitors (SSRIs) such as sertraline [4] [3]. Furthermore, the study suggests that the decrease in REM sleep is most noticeable during the initial stages of treatment and tends to diminish over time [3]. 

What factors influence sertraline-induced drowsiness?

Several factors can influence the severity or duration of drowsiness caused by sertraline. These factors include:

Dosage and time of administration

The dosage of sertraline can influence the severity of drowsiness. Higher doses may increase the likelihood and intensity of drowsiness.

Moreover, taking sertraline at different times of the day can affect drowsiness. Some individuals find that taking it in the morning minimizes drowsiness because it has time to wear off throughout the day. Others may need to take it at night if drowsiness persists to avoid daytime drowsiness.

Drug interactions

The combination of sertraline with other medications or substances can potentially enhance drowsiness. It is important to inform your healthcare provider about any other medications, herbal supplements, or substances you are taking to minimize the risk of drug interactions.

Some examples include:

• Sedatives
• Apomorphine
• Codeine
• Benzodiazepines
• Opioids
• First generation antihistamines
• Alcohol

Age and Health Condition

Elderly individuals and those with certain health conditions may be more susceptible to experiencing drowsiness as a side effect of sertraline.

Additionally, individuals with existing sleep disorders, like obstructive sleep apnea, restless leg syndrome, chronic sleep deprivation, narcolepsy, alcoholism, and periodic limb movement disorder (which is increased during sertraline treatment), may be more likely to experience drowsiness [5] [6].

How to manage sertraline-related drowsiness?

Several approaches can be used to manage sertraline-related drowsiness. It is crucial to consult with your healthcare professional before changing your medication or treatment regimen. They can provide personalized advice, assess your specific situation, and guide you on the best strategies to effectively manage sertraline-induced drowsiness [1].

Here are several factors to consider when managing sertraline-induced drowsiness:

Regimen adjustments

Modify the timing of when you take sertraline, as it may help alleviate drowsiness. Your healthcare professional can guide the optimal dosing schedule. As mentioned previously, switching sertraline administration from morning to night may be beneficial for some people.

In addition, in some cases, your doctor may recommend adding a medication specifically targeted to counteract drowsiness, such as a psychostimulant, alongside sertraline. Examples of these medications include [1]:

• Modafinil
• Bupropion
• Reboxetine
• Protriptyline
• Amphetamines

Lifestyle modification

Prioritize adequate and high-quality sleep. Ensure a consistent sleep schedule, create a bedtime routine, and optimize your sleep environment to promote quality rest. Develop good sleep hygiene practices, such as avoiding caffeine or stimulating activities close to bedtime, keeping your bedroom cool and dark, and creating a relaxing pre-sleep routine [1].

It is also recommended to engage in regular exercise, as it can boost energy levels and improve daytime alertness. Aim for moderate-intensity activities, such as brisk walking or swimming, for at least 30 minutes on most days [1].

Be mindful of substances that can worsen drowsiness, such as alcohol, sedatives, or certain over-the-counter medications. Limit their use or avoid them entirely to help manage sertraline-induced drowsiness.

Conclusion

In conclusion, drowsiness caused by sertraline typically improves within the first few weeks of starting the medication. However, the duration of drowsiness can vary from person to person. Factors such as dosage, overall health, and metabolism can influence the persistence of drowsiness.

Antidepressants like sertraline can affect sleep patterns, including a decrease in REM sleep, leading to difficulties falling asleep, disrupted sleep patterns, and feelings of fatigue and daytime drowsiness. However, this decrease in REM sleep tends to diminish over time.

Several factors can influence the severity or duration of sertraline-induced drowsiness, including the dosage, time of administration, drug interactions, age, and health condition. Managing this drowsiness may involve a combination of strategies such as adding on psychostimulants, adjusting the dosing regimen, practicing healthy sleep habits, and avoiding substances that worsen drowsiness.

It is important to consult with a healthcare professional before making any changes to the medication or treatment regimen. They can provide personalized advice and guide individuals on the best strategies to effectively manage sertraline-induced drowsiness.

References