Does Restasis expire? 

Does Restasis expire? 

Yes, Restasis does expire. You can find the expiry date on the packaging of the medication. Restasis does not have any added preservatives and would become quite unstable once the bottle is opened. 

This is why Restasis is available in the form of single-use vials so that your application will not expose the entire content of the bottle to the environment. Single-use vials should not be left open before use. 

What are the possible dangers associated with the use of expired Restasis? 

Expired Restasis single-use vials don’t pose much of a health risk because their packaging strategy prevents microbial contamination to its best. However, the expired medication will not benefit you either. 

This is because Restasis starts to lose its potency once it’s past the expiration date. Expired meds don’t have any guarantee, either from a manufacturer or your healthcare provider. This is why I would not recommend opting for expired Restasis.

In fact, the Food and Drug Administration has recommended strongly against the use of expired medications, because of a lack of research on their safety and efficacy and no one really knows to what extent they can affect your body (1).

What to do if you have used expired Restasis? 

If you have accidentally used expired Restasis once or twice, don’t worry. However, I would recommend not using it again as there is no easy way for you to determine how much potency of the medication is left. It’s best to talk to your healthcare provider and get a new prescription. 

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U.S. Food and Drug Administration. Don’t Be Tempted to Use Expired Medicines [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2021 [cited 2022 Oct 26]. Available from: