Does Prozac increase dopamine? (+5 effects)

In this article, we will discuss whether Prozac causes an increase in dopamine levels or not, research studies about the relationship and occurrence, benefits and side effects caused due to increased dopamine levels. In addition, factors that may influence the condition and open communication with your healthcare provider will also be discussed. 

Does Prozac increase dopamine?

Yes, Prozac (fluoxetine) can increase dopamine levels in the body. However, Prozac does not increase the levels of dopamine directly in the body. Prozac’s primary action is not related to dopamine levels.

Whereas, there can be a complex interaction between different neurotransmitters in the brain, and some indirect effects on dopamine levels may occur as a result of changes in serotonin levels.  Serotonin and dopamine are the neurotransmitters that play their role in mood regulation, motivation and reward.  

The increase in dopamine levels is not consistent across all people who take Prozac. Some may experience a significant increase in dopamine levels and some may not. 

What does research suggest?

There is a growing body of research on the effects of Prozac on dopamine levels. 

Research has shown that increased serotonin levels with SSRIs like Prozac (fluoxetine) may influence the release and functioning of dopamine in certain brain regions.

In 2002, researchers determined the extracellular increase in dopamine and norepinephrine levels by fluoxetine in rats. Five SSRIs were compared for these effects and only fluoxetine influenced the dopamine and norepinephrine levels in the prefrontal cortex (1). 

Another research study conducted in 2012 concluded that fluoxetine not only influences serotonin but also enhances the influence of dopamine affecting how brain cells communicate in the hippocampus potentially contributing to its antidepressant effects (2).

Similar results were reported in a research study conducted in December 2004 (3). The brain has a complex regulatory mechanism that levels the balance of different neurotransmitters. 

What are the effects of Prozac-induced increased dopamine? 

Increased dopamine levels can have multiple effects that may be positive or negative.

Potential advantages of increased dopamine

The advantages of increased dopamine levels induced by Prozac can have multiple beneficial effects on the patient taking Prozac for its primary effect i.e., antidepressant. Increased dopamine levels can do the following:

Improved mood regulation: Dopamine, a key neurotransmitter plays a role in mood regulation. By increasing dopamine levels, Prozac can contribute to improved mood and potentially alleviate symptoms of depression and anxiety (4).

Enhanced motivation and reward processing: Dopamine is intricately linked to motivation and the brain’s reward system. Prozac-induced increase in dopamine could boost motivation and make it easier to pursue and achieve goals (5). 

Improved cognitive function: Dopamine is essential for cognitive functions such as attention, memory and decision-making. Elevating dopamine levels through Prozac may enhance cognitive abilities, making it easier to concentrate, learn and retain information (6).

Potential for reducing symptoms in neurological disorders: Dopamine dysregulation is a hallmark of certain neurological conditions like Parkinson’s disease and schizophrenia. Increased dopamine levels by Prozac might help alleviate some symptoms associated with disorders.  

Adverse effects of increased dopamine

The potential disadvantages of Prozac-induced increased dopamine levels are as follows:

Psychiatric side effects: When increased levels of dopamine are not balanced by other neurotransmitters, it can lead to psychiatric side effects (7) including anxiety, restlessness, anxiety, agitation, and heightened risk of mania especially in individuals susceptible to mood disorders.

Risk of dependency: Augmenting dopamine activity through Prozac may increase the likelihood of developing dependence on the medication as individuals may become reliant on it for mood regulation and motivation. 

Tolerance and diminished efficacy: Over time the effectiveness of Prozac-induced dopamine modulation may decrease due to the development of tolerance. This may necessitate dose adjustment or the exploration of alternative treatment options. 

Potential for dopaminergic disorders: Excessive or prolonged alterations in dopamine levels may contribute to conditions linked with dopamine dysregulation such as impulse control problems. 

What factors affect Prozac-induced dopamine levels?

While taking Prozac, several factors can impact the levels of dopamine causing an increase in the levels along with increased serotonin levels. The factors may include:

Dose of Prozac: The dose of Prozac taken can affect the degree of dopamine increase.  Higher doses of Prozac may cause a greater increase in dopamine levels than lower doses.

Duration of Prozac treatment: The duration of Prozac treatment may also affect dopamine increase. Prozac may take several weeks or even months to reach its full therapeutic effectiveness. As a result, the dopamine increase may not be noticeable until after several weeks or months of treatment.

Individual sensitivity: Some people may be more sensitive to the dopamine-increasing effects of Prozac. There may be a genetic component involved in this activity.

Other medications: Other medications being taken concurrently with Prozac can interact with the effects of Prozac and affect dopamine levels. Such medications may include antipsychotics that may block the dopamine receptors. 

Underlying health conditions: Certain underlying healthcare conditions such as Parkinson’s disease and thyroid disorders, can also affect dopamine levels in the patients taking Prozac.

Consulting healthcare provider

If you are concerned about the potential side effects of Prozac due to its effects on dopamine levels, it is important to consult your doctor. They can help you weigh the risks and benefits of Prozac treatment and make sure that Prozac is the right medication for you.

Your healthcare provider may focus on the following to evaluate the situation and provide you with a tailored treatment plan.

  • Individual Assessment
  • Medication selection
  • Dosage regimen
  • Monitoring dopamine levels
  • Addressing side effects
  • Potential interactions
  • Periodic review and adjustments
  • Individual response and tolerance
  • Holistic well-being

Consulting your healthcare provider about possible queries is a part of your health treatment strategy. Open communication with your doctor can help navigate the complexities of Prozac and its effects on dopamine levels to achieve optimal health outcomes.


In my opinion, Prozac can cause increased dopamine levels. However, it does not happen with a direct effect. An increase in serotonin levels indirectly increases the dopamine levels. This happens due to the complicated balance of neurotransmitters in the brain.

While taking Prozac, a detailed diagnosis and evaluations are important to avoid the side effects that may appear due to the dopaminergic effects of Prozac. 

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Kobayashi, K., Haneda, E., Higuchi, M., Suhara, T., & Suzuki, H. (2012). Chronic fluoxetine selectively upregulates dopamine D₁-like receptors in the hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(6), 1500–1508.


Bymaster FP, Zhang W, Carter PA, Shaw J, Chernet E, Phebus L, Wong DT, Perry KW. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61. doi: 10.1007/s00213-001-0986-x. Epub 2002 Jan 29. PMID: 11919662.


Jani Penttilä, Jaana Kajander, Sargo Aalto, Jussi Hirvonen, Kjell Någren, Tuula Ilonen, Erkka Syvälahti, Jarmo Hietala, Effects of fluoxetine on dopamine D2 receptors in the human brain: a positron emission tomography study with [11C]raclopride, International Journal of Neuropsychopharmacology, Volume 7, Issue 4, December 2004, Pages 431–439,


Sohel, A. J. (2022, July 4). Fluoxetine. StatPearls – NCBI Bookshelf.


Small DM, Jones-Gotman M, Dagher A (2003) Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 19:1709–1715. 10.1016/S1053-8119(03)00253-2 [PubMed] [CrossRef] [Google Scholar]


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Franco, R., Reyes-Resina, I., & Navarro, G. (2021). Dopamine in Health and Disease: Much More Than a Neurotransmitter. Biomedicines, 9(2), 109.

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