Does Prozac affect Xanax? (3+ benefits)

In this article, we aim to answer the query: “Does Prozac affect Xanax?” Additionally, we will discuss how Prozac affect the effectiveness of Xanax, its benefits, side effects and precautions while taking the combination of Prozac and Xanax. 

Does Prozac affect Xanax?

Yes, Prozac affects Xanax when taken in combination. Prozac reduces the metabolism rate of Xanax in the body by affecting an enzyme that metabolizes Xanax. Due to this mechanism, Xanax’s half-life is increased and it remains for a longer period in the bloodstream.

However, the mechanism by which Xanax works in the body is not affected by Prozac (1). Prozac and Xanax both are prescription drugs and should only be taken after prescribed by your medical practitioner. 

If your doctor prescribes the Prozac and Xanax combination, regular monitoring is necessary, as it may cause extreme drowsiness making people unable to do their daily tasks. Prozac is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class of drugs. 

SSRIs block the reuptake of serotonin in brain cells and serotonin is responsible for controlling appetite, mood, sleep, and the body’s stress response (2). Xanax is a psychotropic medicine of the Benzodiazepine class of drugs. Xanax attaches to GABA (brain receptor), which relaxes the brain and reduces stress (3). 

Prozac is FDA-approved to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and other related mental health conditions (2). Xanax, on the other hand, is approved by the FDA to treat anxiety and panic disorders. Xanax may also be prescribed for the treatment of depression, sleep disturbances, and premenstrual syndrome (3). 

How does Prozac affect the effectiveness of Xanax?

When Prozac and Xanax are administered together, they may lead to severe drowsiness and patients are unable to perform daily tasks that require concentration.

A research study was conducted in which a group of patients were administered a combination of Xanax and Prozac; another group was given Prozac alone, to check how the patients differed in response to these therapies.

The study suggested that the concentration of Xanax was increased in the blood and it remained for a longer period in the bloodstream. Additionally, patients who took the combination of Xanax and Alprazolam experienced extreme dizziness as compared to the group of patients who took Prozac alone (4,5). 

In a clinical trial, when patients with depression experienced jitteriness (involuntary movement of a body part) with Prozac, they were given Xanax for a short period. The symptoms of jitteriness disappeared while patients were taking Xanax. Even after discontinuing Xanax, these symptoms did not return (6).  

What are the benefits of Prozac and Xanax combination?

The benefits of Prozac and Xanax combination may include: 

  • This combination may provide quick relief from stress and anxiety. 
  • It reduces the symptoms of Prozac-induced anxiety or irritability that may occur in the initial phase of therapy. 
  • The improved overall condition makes it easier for patients to adhere to the combination therapy.
  • Patients may easily manage anxiety in stressful situations (7).

What are the side effects of Prozac and Xanax combination?

The common side effects of Prozac and Xanax combination may include: 

  • Dizziness
  • Nausea
  • Diarrhea or constipation
  • Dry mouth 
  • Weight changes 
  • Headaches
  • Confusion (8,9)

It is important to note that not everyone taking the combination of Prozac and Xanax may experience these side effects. However, if you experience any side effects that worsen or persist, please inform your healthcare provider. 

What are the precautions while taking the Prozac and Xanax combination?

While taking a combination of Prozac and Xanax, inform your doctor if you are: 

  • Allergic to either Prozac or Xanax.
  • You are taking other medicines or herbal supplements.
  • You are pregnant or planning to become pregnant, as Prozac has sexual side effects. 
  • You are having dental surgery. 
  • This combination can make you drowsy, so avoid driving and do not consume alcohol (8,9). 


In my opinion, Prozac and Xanax when taken in combination, Prozac can affect how Xanax is metabolised in the body. While this combination may provide quick relief from stress and anxiety and help manage Prozac-induced symptoms, it can also result in severe drowsiness and other side effects. 

You should only take this combination of Prozac and Xanax under the guidance of your healthcare provider, as their effects may vary from person to person. It is important to be aware of the potential side effects of this combination and inform your healthcare provider if you notice any side effects that worsen or persist. 

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