Does Pristiq make you hyperactive? (+3 factors)

In this article, we will discuss whether Pristiq can make you hyper. We will also discuss the symptoms of Pristiq-induced hyperactivity and what one should do if this side effect occurs.

Does Pristiq make you hyperactive?

Pristiq (Desvenlafaxine) may cause hyperactivity in some individuals. However, it is not a common side effect and the incidence is low.

In fact, for individuals with depression who have low energy levels, it can be beneficial if Pristiq helps increase their activity levels.

However, if someone experiences significant hyperactivity or restlessness while taking Pristiq, it would be considered an undesirable effect and should be discussed with a healthcare provider.

It is important to note that individual responses to medications vary, and certain people might be at a higher risk of experiencing hyperactivity due to Pristiq. So, it is important to discuss your concerns or observed changes in behaviour with your healthcare provider.

How can Pristiq cause hyperactivity?

The exact mechanism responsible for Pristiq-induced hyperactivity is not fully known, but it is believed to involve changes in the serotonin and norepinephrine levels in the brain (1).

These neurotransmitters (serotonin and norepinephrine) play a role in mood regulation and alterations in their balance can affect various brain functions, including activity levels.

It is important to note that Pristiq may cause a temporary increase in restlessness, insomnia or hyperactivity, particularly during the early course of treatment with Pristiq. However, this effect tends to subside as the body adjusts to the medication (2).

It is crucial to emphasize the overall benefits of Pristiq in treating anxiety and depression outweigh the potential side effects. It’s worth mentioning that everyone’s response to medication is unique, and individual experiences may vary.

What does research suggest?

There is limited research indicating Pristiq-induced hyperactivity. However, one study indicated that Pristiq at doses of 50 and 100 mg per day helped people with major depressive disorder feel more energetic and less tired (3).

Feeling better in terms of energy and having fewer ongoing tiredness issues were linked to getting better at daily tasks (3).

However, it is important to note that drowsiness, fatigue, dizziness, decreased energy and activity levels are most commonly associated with Pristiq use rather than hyperactivity. 

What are the symptoms of Pristiq-induced hyperactivity?

Symptoms of hyperactivity caused by antidepressants, including Pristiq, may include:

• Restlessness-unable to relax.
• Difficulty staying still, moving non-stop, tapping fingers or feet, or feeling a strong need to keep moving around.
• Experiencing racing thoughts, making it difficult to focus or concentrate.
• Acting without thinking about the outcomes or being impulsive.
• Agitation and feeling irritable or easily provoked.
• Increased energy levels.

What factors influence Pristiq-induced hyperactivity?

Several factors can potentially influence the occurrence of Pristiq-induced hyperactivity. These factors include:

Individual variation: Each person’s response to medication can vary. Some individuals may be more susceptible to hyperactivity while taking Pristiq.

High dosage: Higher doses of Pristiq may increase the risk of experiencing hyperactivity as a side effect. Moreover, jumping to higher doses without proper escalation can also lead to increased side effects like hyperactivity.

Underlying health conditions: Certain medications, such as attention deficit hyperactivity disorder (ADHD), and bipolar disorder may predispose individuals to hyperactive reactions while taking Pristiq.

Drug interactions: Concurrent use of certain medications, such as stimulants or other psychiatric medications that modulate neurotransmitters, may potentially increase the risk of hyperactivity while taking Pristiq.

How to avoid Pristiq-induced hyperactivity?

To avoid the risk of Pristiq-induced hyperactivity, you should adhere to the dosage prescribed by your healthcare provider. Avoid altering the dosage without consulting them first.

Inform your doctor about any changes in your symptoms or concerns regarding hyperactivity.

Inform your doctor about any other medications or supplements you are taking. They can assess potential drug interactions and adjust your treatment plan accordingly.

It is recommended to ensure that any underlying medical conditions, such as bipolar disorder or ADHD are effectively managed alongside Pristiq treatment. This can help minimize hyperactive symptoms.

What to do if Pristiq causes hyperactivity?

If you find that Pristiq is causing hyperactivity, it is important to address this issue with your healthcare provider.

They may assess your condition and find out if Pristiq is the main culprit. If Pristiq is the causative agent, they may consider reducing its dosage.

If dose reduction is not helpful your doctor may discontinue your medication gradually or switch to another antidepressant to alleviate hyperactivity.

Never make dosage adjustments or switch medication without consulting your doctor first. Abrupt discontinuation of antidepressants including Pristiq can lead to horrible withdrawal symptoms (4).

It is also advisable to limit stimulants like caffeine and alcohol. Minimize intake of these substances to reduce the risk of hyperactivity while taking Pristiq.

You should also explore non-medication alternatives to manage hyperactivity, like therapy, lifestyle changes, and healthy coping mechanisms. Additionally, physical activity can help release excess energy and promote relaxation.

Final words

Based on my research and understanding, Pristiq may cause rare instances of hyperactivity as a side effect. However, this is very uncommon and there are no specific case reports or clinical studies directly linking Pristiq to hyperactivity.

In my view, individual responses to medications can vary and certain people may be at a higher risk of experiencing hyperactivity due to Pristiq.

In the case of Pristiq-induced hyperactivity, I recommend communicating with your healthcare provider for personalized guidance and treatment plans.  

References