Does Pristiq affect memory? (+3 findings)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether or not Pristiq affects memory, research studies on the impact of Pristiq on memory and other cognitive functions, factors that can contribute to memory loss and other cognitive problems while taking Pristiq, what you should do if Pristiq negatively affects your memory, and lifestyle tips for enhancing your memory.
Does Pristiq affect memory?
Yes, Pristiq can cause memory problems in certain individuals. Memory problems are a possible side effect of taking Pristiq. Confusion, trouble focusing, and an overall sense of being less alert than usual are possible symptoms of these memory problems. (1)
Pristiq is the brand name of the antidepressant medication desvenlafaxine. It belongs to the class of drugs known as SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors). Pristiq functions by increasing the concentrations of serotonin and norepinephrine levels in the brain. (2)
Serotonin and norepinephrine are natural neurotransmitters that play a role in regulating your sleep, memory, and mood. Increased levels of these neurotransmitters may negatively affect your memory.
Pristiq may have an impact on the hippocampus, a part of the brain involved in the formation and storage of memories. Pristiq adjusts the activity of specific proteins and neurotransmitters in the hippocampus which can result in memory problems in certain individuals. (3)
What does research suggest?
A research study was conducted to evaluate the impact of desvenlafaxine on cognitive and memory function in patients with MDD (Major Depressive Disorder). The participants received a 50 mg dose of desvenlafaxine for 12 weeks.
Desvenlafaxine was found to significantly increase working memory speed and quality. Additionally. According to the study’s findings, desvenlafaxine 50 mg/day for the treatment of depression may enhance working memory among other cognitive abilities. (4)
Other research data suggests that desvenlafaxine can result in confusion, memory problems, and trouble focusing. However, it’s crucial to remember that each person’s experience with medication is different, and different people will have different side effects. (5)
What factors may contribute to memory issues while taking Pristiq?
There are several factors that can contribute to memory and cognitive problems while taking Pristiq such as: (6), (7)
Medication dose: High Pristiq doses can contribute to memory problems and other cognitive issues.
Underlying medical conditions: Certain medical conditions such as neurodegenerative diseases like Alzheimer’s disease, dementia, and brain tumors can induce memory loss and cognitive problems while taking Pristiq.
Concurrent medications: Cancer treatment like chemotherapy, anti-anxiety medications, tranquilizers, sedatives, and hypnotics can all induce memory and cognitive problems while taking Pristiq.
Nutritional deficiency: A diet that lacks important minerals, vitamins, proteins, and healthy fats such as omega-3 can induce memory and cognitive issues while using Pristiq.
Stress and sleep deprivation: Overstressing and lack of sleep (less than 6 hours per day) can contribute to difficulty concentrating, and memory problems.
Age: The elderly population is more prone to experiencing memory and cognitive problems than the younger population.
Lifestyle factors: Smoking, tobacco, and alcohol can all induce memory and cognitive issues while taking Pristiq.
What should you do if Pristiq negatively affects your memory?
If Pristiq negatively affects your memory, consult your healthcare provider about reducing your medication dose. Your healthcare provider might gradually reduce your dose over a period of weeks or months.
According to your condition, your healthcare provider might reduce your dose by 10-20% per week. You should take the reduced dose for at least one week before reducing the dose again.
Additionally, your healthcare provider will thoroughly evaluate your situation to determine whether Pristiq is the cause of memory and cognitive problems or whether there is an underlying medical condition such as Alzheimer’s disease and dementia that causes memory and cognitive dysfunction.
If Pristiq is the cause of memory issues and if this side effect is persistent despite reducing your dose, your healthcare provider might switch you to an alternative with fewer adverse events.
What are Pristiq alternatives with fewer memory-related side effects?
There are certain Pristiq alternatives with fewer memory-related side effects such as:
- Agomelatine. A novel atypical antidepressant that is proven effective in treating memory disorders in certain individuals. (8)
- Tianeptine. It is an atypical tricyclic antidepressant. According to research, Tianeptine is shown to have memory-protective properties. (9)
- Mirtazapine. An atypical antidepressant that is shown to improve memory activity in certain individuals. (10)
- Paxil: It is an SSRI antidepressant that is found effective in treating depression and can have positive effects on memory functions.
Lifestyle tips for enhancing your memory
There are several lifestyle tips to enhance your memory, some of which include: (11)
Brain training
Doing challenging puzzles like crosswords, sudoku, or word games, and mastering a new skill can help in enhancing your memory. These Puzzles and games challenge your memory and can help keep your brain sharp and improve recall.
Exercise
Regular exercise, especially aerobic exercises like running, cycling, walking, or swimming has been shown to increase blood flow to the brain which can improve your memory and cognitive function.
Healthy nutrition
Eating a healthy nutritious diet that is rich in nuts, whole grains, vegetables, and fruits can supply your brain with the vital nutrients it needs to function optimally. Examples include broccoli, dark leafy greens, avocados, berries, grapes, and watermelon.
Sufficient sleep
Sleeping for 7 to 8 hours per night can help in enhancing your cognitive function and memory. During sleep, your brain consolidates memories, which means it sorts through and organizes new information, making it easier to remember later.
Based on my knowledge and research, Pristiq can cause memory problems in certain individuals. However, this side effect is not common and can vary from person to person.
If you experience memory and cognitive issues while taking Pristiq, consult your healthcare provider about reducing your medication dose or switching to an alternative with fewer cognitive-related side effects.
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References
1.-
Desvenlafaxine (Oral Route) Side Effects – Mayo Clinic [Internet]. www.mayoclinic.org. [cited 2023 Nov 22]. Available from: https://www.mayoclinic.org/drugs-supplements/desvenlafaxine-oral-route/side-effects/drg-20071583?p=1#:~:text=Check%20with%20your%20doctor%20right
2.-
Naseeruddin R, Rosani A, Marwaha R. Desvenlafaxine [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534829/#:~:text=Desvenlafaxine%20is%20an%20antidepressant%20that,treat%20hot%20flashes%20during%20menopause.
3.-
Asokan A, Ball AR, Laird CD, Hermer L, Ormerod BK. Desvenlafaxine May Accelerate Neuronal Maturation in the Dentate Gyri of Adult Male Rats. Borlongan CV, editor. PLoS ONE. 2014 Jun 4;9(6):e98530. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045676/
4.-
Reddy S, Fayyad R, Edgar CJ, Guico-Pabia CJ, Wesnes K. The effect of desvenlafaxine on cognitive functioning in employed outpatients with major depressive disorder: a substudy of a randomized, double-blind, placebo-controlled trial. Journal of Psychopharmacology. 2016 Mar 23;30(6):559–67. Available from: https://pubmed.ncbi.nlm.nih.gov/27009044/
5.-
HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet]. [cited 2023 Nov 22]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021992s042lbl.pdf
6.-
Forget me not: What to remember about memory loss [Internet]. Cleveland Clinic. Available from: https://my.clevelandclinic.org/health/symptoms/11826-memory-loss
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Mary Anne Dunkin. Memory Loss [Internet]. WebMD. WebMD; 2011. Available from: https://www.webmd.com/brain/memory-loss
8.-
Qi JS, Su Q, Li T, Liu GW, Zhang YL, Guo JH, et al. Agomelatine: a potential novel approach for the treatment of memory disorder in neurodegenerative disease. Neural Regeneration Research. 2023;18(4):727. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9700086/
9.-
Zoladz P, Park C, Munoz C, Fleshner M, Diamond D. Tianeptine: An Antidepressant with Memory-Protective Properties. Current Neuropharmacology. 2008 Dec 1;6(4):311–21. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701287/
10.-
Nowakowska E, Chodera A, Kus K. Behavioral and memory improving effects of mirtazapine in rats. Polish Journal of Pharmacology [Internet]. 1999 [cited 2023 Nov 22];51(6):463–9. Available from: https://pubmed.ncbi.nlm.nih.gov/10817523/#:~:text=In%20the%20maze%20test%2C%20mirtazapine,its%20earlier%20impairment%20by%20scopolamine.
11.-
Mayo Clinic Staff. Memory loss: 7 Tips to Improve Your Memory [Internet]. Mayo Clinic. 2019. Available from: https://www.mayoclinic.org/healthy-lifestyle/healthy-aging/in-depth/memory-loss/art-20046518
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