Does Paxil helps premenstrual dysphoric disorder? (3+ risks)
By
Dr Drielli Vital-Fujii (PhD)
Author bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
In this article, we will discuss whether Paxil helps with Premenstrual Dysphoric Disorder (PMDD). We’ll look at what the research says and the potential side effects and risks associated with it. Join us to understand more about this common concern for those using Paxil on their mental health journey.
Does Paxil helps premenstrual dysphoric disorder?
Yes, Paxil is known to be effective in treating Premenstrual Dysphoric Disorder (PMDD). However, it’s essential to consult with a healthcare professional for personalized advice and the proper dosage, as individual responses to medication can vary.
How does Paxil helps Premenstrual Dysphoric Disorder?
Premenstrual Dysphoric Disorder (PMDD) is a condition that affects women before their menstrual period. It goes beyond your typical premenstrual symptoms and can cause severe mood swings, irritability, and physical discomfort. In more severe cases, PMDD can significantly impact a person’s daily functioning and quality of life.
Paxil (Paroxetine) is part of the Selective Serotonin Reuptake Inhibitors (SSRIs) along with Citalopram and Sertraline. These medications work by increasing the levels of serotonin in the brain, a neurotransmitter that plays an important role in mood regulation. By enhancing serotonin levels, SSRIs like Paxil help reduce the emotional symptoms associated with PMDD.
It’s important to note that while Paxil and other SSRIs can be effective in managing PMDD, individual responses to medication vary. Some individuals may experience relief from symptoms, while others may not respond as well or may encounter side effects. Therefore, working closely with your healthcare professional is crucial to finding the most suitable treatment plan.
What does research suggest?
Research consistently proves the effectiveness of Paxil in treating Premenstrual Dysphoric Disorder (PMDD). In a randomized, double-blind trial, Paxil demonstrated a significant reduction in both emotional and physical symptoms associated with PMDD. Users of Paxil reported significant reductions in physical discomfort and evident mood improvements.
In a placebo-controlled trial, the comparison between Paxil and a placebo consistently shows that Paxil works better at reducing PMDD symptoms like irritability, mood swings, and general distress. This proves that Paxil is a safe and successful treatment for PMDD. (1)
Another study investigates the effectiveness of Paroxetine in treating (PMDD) in oriental women. The study compares continuous and intermittent Paroxetine treatment over six months. The study involves 36 subjects who were initially drug-free for two cycles, followed by two cycles of daily Paroxetine. Both treatment protocols show significant improvements in PMDD symptoms, with response rates ranging from 50% to 78.6% in the continuous-treatment group and 37.5% to 93.8% in the intermittent-treatment group.
The results showed that both ways of taking paroxetine led to significant improvements in PMDD symptoms, like mood changes and physical discomfort. The women in both groups experienced positive effects that lasted for six consecutive menstrual cycles. (2)
Despite these positive findings, it’s important to acknowledge the potential for individual differences in Paxil responses.
What risks come with using Paxil for PMDD?
Common side effects
Like many medications, Paxil can cause common side effects such as nausea, drowsiness, dizziness, and insomnia. These effects are usually temporary and may lessen as the body adjusts to the medication.
Withdrawal symptoms
Paxil, being an SSRI, can, in rare cases, lead to serious conditions. Abruptly stopping Paxil can result in withdrawal symptoms such as irritability, nausea, dizziness, and vivid dreams and, in extreme cases, may contribute to serotonin syndrome, a potentially serious condition characterized by symptoms such as confusion, hallucinations, rapid heartbeat, and severe nausea.
Sexual side effects and other considerations
SSRIs like Paxil can lead to sexual side effects, including reduced libido and difficulty achieving climax. Pregnant or breastfeeding individuals should consult their healthcare provider about the potential risks and benefits, as SSRIs, including Paxil, have associated pregnancy risks. Moreover, caution is advised regarding an increased risk of bleeding, especially when combined with specific medications or conditions affecting blood clotting, particularly for those on blood-thinning medications.
Are there alternatives to Paxil to treat PMDD?
There are alternative treatments for Premenstrual Dysphoric Disorder (PMDD) besides Paxil. Some commonly prescribed alternatives include:
Selective Serotonin Reuptake Inhibitors (SSRIs): Other SSRIs like Prozac (Fluoxetine) or Zoloft (Sertraline) may be prescribed, as they also work to balance serotonin levels and alleviate PMDD symptoms.
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Medications such as Effexor (Venlafaxine) can be considered. SNRIs affect both serotonin and norepinephrine levels in the brain.
Birth Control Pills: Oral contraceptives are sometimes recommended to regulate hormonal fluctuations and reduce PMDD symptoms.
Cognitive-Behavioral Therapy (CBT): This form of psychotherapy can be effective in helping individuals cope with the emotional aspects of PMDD.
Lifestyle Changes: Adopting a healthy lifestyle, including regular exercise, a balanced diet, and stress management techniques, can also contribute to managing PMDD symptoms.
Conclusion
I conclude that using Paxil to address Premenstrual Dysphoric Disorder (PMDD) can prove beneficial, but it needs careful evaluation of both benefits and risks.
I believe individuals considering Paxil for PMDD should have an open and honest discussion with their healthcare provider. This involves disclosing existing medical conditions, medications, and concerns in order to fully understand the advantages and disadvantages of each option. Regular check-ins with a healthcare professional are important to monitor the medication’s effectiveness and manage any emerging issues.
Was this helpful?
References
1.-
Pearlstein TB, Bellew KM, Endicott J, Steiner M. Paroxetine Controlled Release for Premenstrual Dysphoric Disorder: Remission Analysis Following a Randomized, Double-Blind, Placebo-Controlled Trial. Prim Care Companion J Clin Psychiatry. 2005;7(2):53-60. doi: 10.4088/pcc.v07n0203. PMID: 15841196; PMCID: PMC1079696.
2.-
Wu KY, Liu CY, Hsiao MC. Six-month paroxetine treatment of premenstrual dysphoric disorder: continuous versus intermittent treatment protocols. Psychiatry Clin Neurosci. 2008 Feb;62(1):109-14. doi: 10.1111/j.1440-1819.2007.01785.x. PMID: 18289149.
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