Does Nystatin expire? 

Does Nystatin expire? 

Yes, Nystatin does expire. Nystatin is usually available for topical administration in the form of suspension, ointment, or creams. These dosage forms should not be used past the expiration date printed on the packaging of the product. 

This is because such dosage forms are not that stable and the way they are used can promote microbial contamination. They also contain high moisture content compared to solid oral dosage forms (tablets) which can serve as a hospitable environment for bacteria to grow. 

It is important to note that antimicrobials need to be fully potent to help manage the growth of infection-causing microbes. So, always check for expiry dates on antifungal formulations, including Nystatin – both separate and combined formulations, such as Nystatin and Triamcinolone acetonide cream.

What dangers are associated with the use of expired Nystatin? 

A few dangers associated with the use of expired Nystatin preparation include:

Therapeutic failure 

Therapeutic failure is one of the most common concerns with using expired medications. The drug can change its antifungal properties and may not work with full potency (1). 

This can lead to therapeutic insufficiency and you will not see any difference in the progression of your fungal infection. This is why it’s best to stick with Nystatin that’s still in effect. 

Bacterial infection 

The thing with liquid preparations is that they could become an excellent medium for bacterial growth. This is why such formulations have well-added preservatives. 

When the med goes past the expiration date, there is no guarantee that the preservatives will work as effectively as they should, which increases the risk of microbial contamination. If you use contaminated Nystatin, you may get infected as well. 

Drug resistance 

If you continue to provide your body with ineffective Nystatin, your body will eventually build resistance against it. This can hinder the effects of Nystatin in future use and you may need higher and more frequent dose administrations to achieve the desired antifungal response. 

What to do if you have used expired Nystatin?

If you have used expired Nystatin and you are experiencing signs of an allergic reaction, or an infection, immediately reach out to your healthcare provider. An expired antifungal can exacerbate your infection, instead of treating it. 

This is why you should never go for expired antimicrobials for your active infection. However, if you have accidentally used it once, it shouldn’t bother you and if it does, seek medical attention. 

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U.S. Food and Drug Administration. Don’t Be Tempted to Use Expired Medicines [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2021 [cited 2022 Oct 17]. Available from: