Does Nasacort increase blood pressure?
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
Does Nasacort increase blood pressure?
No, Nasacort does not increase blood pressure usually. In fact, it is considered safe to be used by hypertensive patients and does not interact with any antihypertensive medication (1).
However, Nasacort has a corticosteroid in it, which most likely will not affect your blood pressure but it can affect the amount of water and electrolytes in your body. This can lead to water retention which may increase your blood pressure.
However, it’s a long shot with Nasacort as it’s a nasal spray and the amount of corticosteroids entering your body through a single dose administration is not significant enough to cause water retention or high blood pressure.
If you are concerned about high BP, talk to your healthcare provider. Other factors could be responsible for your high blood pressure, and proper evaluation is necessary to address the problem.
What side effects are common with Nasacort?
Nasacort, although it does not increase blood pressure, is associated with some side effects – ranging from mild and common to rare and serious. (1,2)
Common side effects:
- Nasal irritation or dryness
- Sneezing or runny nose
- Throat irritation or sore throat
- Headache
- Nausea
- Cough
- Burning or itching sensation in the nose
Rare side effects:
- Nasal bleeding
- Nasal septum perforation (a small hole in the nasal septum)
- Allergic reactions (rash, itching, swelling)
- Vision changes or blurred vision
- Increased eye pressure (in individuals with underlying glaucoma)
- Adrenal suppression (with long-term use or high doses)
- Growth suppression in children (with long-term use or high doses)
It is important to note that individual experiences may vary. If you experience any concerning or persistent side effects while taking Nasacort, it is important to consult your healthcare provider.
What to do if your blood pressure increases while taking Nasacort?
If you notice that your blood pressure increases while taking Nasacort, it is important to reach out to your healthcare provider. They can evaluate your situation and determine the appropriate course of action.
It may be necessary to adjust your dosage or explore alternative treatment options. It is important to communicate any changes in your health, including blood pressure fluctuations, to your healthcare provider so that they can provide you with the necessary guidance and support.
Meanwhile, there are some tips that can help you manage your blood pressure. These include: (3)
- Follow a healthy diet that is low in sodium and high in fruits, vegetables, and whole grains.
- Engage in regular physical activity or exercise, such as walking or cycling.
- Maintain a healthy weight through proper diet and exercise.
- Limit your alcohol intake and avoid smoking.
- Manage stress through relaxation techniques, such as deep breathing or meditation.
- Get enough sleep and practice good sleep hygiene.
- Limit your caffeine consumption.
- Follow your healthcare provider’s instructions and take any prescribed medications as directed.
- Stay hydrated by drinking plenty of water throughout the day.
- Limit your intake of processed and fatty foods.
- Reduce your salt intake by avoiding high-sodium processed foods.
- Consult with your healthcare provider before making any changes to your medication or treatment plan.
- Keep a record of your blood pressure readings to track any changes or trends.
Final words
To sum up, NAsacort does not cause an increase in blood pressure. This is not a commonly reported side effect, but it may affect some people. This is why it’s best to monitor your side effects and report them to your doctor.
Remember, your healthcare provider is the best person to advise you on how to manage any potential concerns related to your blood pressure while using Nasacort or any other medication for that matter.
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References
1.-
Sidhu G, Preuss CV. Triamcinolone. 2023 Mar 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31335029. https://www.ncbi.nlm.nih.gov/books/NBK544309
2.-
Rosenthal R, Berger W, Bronsky E, Dockhorn R, Korenblat P, Lampl K, Lumry W, Pollard S, Raphael G, Rohr C, Shapiro G, Valentine M, Wanderer A, Fleming L, LaVallee N, Stepanians M, Karafilidis J, Shilstone J, Ellis E. Tri-Nasal triamcinolone acetonide nasal spray 200 and 400 micrograms qd versus placebo and Nasacort triamcinolone acetonide nasal aerosol 440 micrograms qd in patients suffering from seasonal allergic rhinitis during the grass season. Am J Rhinol. 1998 Nov-Dec;12(6):427-33. doi: 10.2500/105065898780707991. PMID: 9883300. https://pubmed.ncbi.nlm.nih.gov/9883300/
3.-
Gupta R, Guptha S. Strategies for initial management of hypertension. Indian J Med Res. 2010 Nov;132(5):531-42. PMID: 21150005; PMCID: PMC3028941. https://pubmed.ncbi.nlm.nih.gov/21150005/
