Does Naproxen contain Aspirin? 

Does Naproxen contain Aspirin? 

No, Naproxen does not contain Aspirin but they both are non-steroidal anti-inflammatory drugs (NSAIDs). Both Naproxen and Aspirin work in the same way, as they belong to the same class of meds. However, they are different in a few ways. 

How is Aspirin different from Naproxen? 

Although both of these medications inhibit Prostaglandin synthesis which in turn reduces the blood’s ability to clot and platelet functions, Aspirin does it more prominently(12)

This is why Aspirin can be used as a blood thinner in cardiac patients, but Naproxen can not. On the other hand, Naproxen is found to be better at managing pain and inflammation, as compared to Aspirin. 

Both of these meds have their own pros and cons, and they may affect people differently. Some may find better pain relief from Aspirin as compared to Naproxen, or vice versa. 

What are the side effects caused by Aspirin and Naproxen? 

One general concern with both Aspirin and Naproxen is the severity of gastrointestinal side effects these meds can cause. This usually happens because both of these NSAIDs can damage the protective mucosal lining around your stomach, which is made of Prostaglandins. 

Since Prostaglandins are inhibited by the NSAID, your stomach becomes vulnerable to the damage caused by these meds. Common side effects associated with these meds are(3)

  • Nausea
  • Vomiting 
  • Abdominal pain
  • Acid reflux 
  • Flatulence 

Rare and serious side effects include:

  • An allergic reaction or hypersensitivity 
  • Arrhythmia or abnormal heartbeat
  • Irregular breathing 
  • Tremors 
  • Bloody vomiting 
  • Loss of hearing
  • Black or tarry stools – indicating gastrointestinal bleeding
  • Ulceration 

Make sure you avoid NSAIDs if you have an underlying gastrointestinal disease, like gastric or duodenal ulcers or gastroesophageal reflux disease (GERD). 

It is also not suitable to take NSAIDs if you have a bleeding disorder or if you’re currently taking other medications which can cause blood thinning or increase the risk of bleeding. If you’re concerned about any of the side effects, reach out to your doctor or pharmacist. 

Final words

Both Aspirin and Naproxen are NSAIDs and can be used for several purposes. Both of these meds are available over the counter. It is best to ask your pharmacist which one of them would be better for you, according to your symptoms. 

It is also important to make sure you properly read the label of these OTC meds and take them as directed. If you are not sure how much and how often to take, you should ask your pharmacist.

Was this helpful?

Thanks for your feedback!



PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 156391, Naproxen; [cited 2023 Mar. 03]. Available from:


PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 2244, Aspirin; [cited 2023 Mar. 03]. Available from:


Ghlichloo I, Gerriets V. Nonsteroidal Anti-inflammatory Drugs (NSAIDs). 2022 May 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31613522. Available from: