Does Imitrex have Aspirin in it? 

Does Imitrex have Aspirin in it? 

No, Imitrex (Sumatriptan) does not have Aspirin in it. These two meds are entirely different and are used for different clinical purposes. Imitrex and Aspirin work in different ways, target different receptors in your body and have different side effects profiles. 

Aspirin is available over the counter, but Imitrex is a prescription medication and should only be used if your doctor has prescribed it. 

Differences between Imitrex and Aspirin

Imitrex is quite different from Aspirin. Let’s pen down the basic differences: 

Mechanism of action and clinical efficacy

Imitrex is primarily used for the management and treatment of migraine headaches. It’s a serotonin receptor agonist, which basically causes the construction of blood vessels in your brain(1)

This way, the signal of the brain that triggers migraine is disrupted and symptoms like headache, nausea, dizziness, etc are relieved. Imitrex is an overall well-tolerated medication. 

Although it doesn’t reduce the frequency of your migraine attacks or prevent them, it does reduce the intensity of the pain – which is the biggest relief for someone suffering from these terrible headaches. 

Aspirin, on the other hand, is an OTC painkiller which is used to manage fever, pain, and inflammation. It can also be used as a blood thinner because of its antiplatelet effects(2)

Aspirin basically inhibits Prostaglandin synthesis, which is an important mediator of pain and inflammation.

Common and rare side effects reported

Imitrex and Aspirin are associated with some side effects. These include:

Common side effects of Imitrex

  • Drowsiness 
  • Fatigue 
  • Weakness 
  • Diarrhoea 
  • Upset stomach 
  • Muscle cramps
  • Tingling sensation 
  • Flushing 

Serious and rare side effects include:

  • An allergic reaction 
  • Tightness and pain in the chest along with difficulty in breathing 
  • Difficulty in speech
  • Extreme weakness 
  • Severe stomach pain 
  • Bloody diarrhoea 
  • Unexplained weight loss 
  • Pale colouration of skin
  • Vision changes 
  • Convulsions 

Common side effects of Aspirin

  • Nausea
  • Vomiting 
  • Abdominal pain
  • Acid reflux 
  • Flatulence 

Rare and serious side effects include:

  • An allergic reaction or hypersensitivity 
  • Arrhythmia or abnormal heartbeat
  • Irregular breathing 
  • Tremors 
  • Bloody vomiting 
  • Loss of hearing
  • Black or tarry stools – indicating gastrointestinal bleeding
  • Ulceration 

Final words

To sum up, Imitrex and Aspirin are different medications. You can get Aspirin without a prescription but do not take Imitrex without your doctor’s approval. Both meds are associated with some side effects, which should be properly monitored. 

Make sure you avoid using these meds if you’re allergic to them. In the case of Aspirin, it is best to avoid this medication if it causes GI side effects. Aspirin can increase the risk of bleeding in people with already-existing GI illnesses and it should not be used in people with bleeding disorders. 

Imitrex can be taken with or without food. However, Aspirin should be taken with food by people who are sensitive to gastrointestinal side effects. If you are sensitive to certain side effects, please talk to your doctor or pharmacist before taking these medications.

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PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 5358, Sumatriptan; [cited 2023 Mar. 03]. Available from:


PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 2244, Aspirin; [cited 2023 Mar. 03]. Available from: