Does green tea interact with Zoloft? (+5 Safety tips)

In this article, we’ll address the question: ‘Does green tea interact with Zoloft?’ We’ll also delve into the research and explore potential side effects.

Does green tea interact with Zoloft?

Yes, green tea can interact with Zoloft (Sertraline). When taken together, it can increase the risk of bleeding especially if green tea is consumed in large quantities.

Zoloft and green tea can also cause gastrointestinal side effects. It’s advised not to take Zoloft and green tea together.

Green tea is widely consumed for weight loss and mental alertness. It is a common refreshing beverage. Sertraline is used to treat depression, anxiety and mood disorders.

What does research suggest?

Some studies have reported interactions between green tea and sertraline.

A study explored herb-drug interactions and found that the chances of interaction between green tea and prescription medicines, including Sertraline, were “probable” in 51% of the reports and “highly probable” in approximately 8%. About 37% were classified as possible herb-drug interactions, while only 4% were considered doubtful. (1)

Studies suggest that green tea and sertraline individually may elevate the risk of bleeding especially in patients with ulcers. This risk is high if these are taken together. Therefore, it’s advisable to consider limiting green tea consumption or avoiding it altogether when taking sertraline. (2,3)

Studies and reports have also highlighted various gastrointestinal side effects associated with green tea consumption. These include issues such as acid reflux and heartburn, often attributed to green tea’s caffeine content, which can relax the lower oesophagal sphincter. (4)

Similarly, sertraline (Zoloft), is known to be associated with its own set of gastrointestinal side effects. Nausea and vomiting are relatively common, particularly when initiating treatment with sertraline. (2)

These research findings collectively shed light on the potential interactions and effects of green tea when combined with sertraline, offering valuable insights for those considering this combination.

Potential side effects of Sertraline and green tea

Combining sertraline with green tea can potentially lead to several side effects, including:

Gastrointestinal Issues

Both sertraline and green tea have been associated with gastrointestinal problems. Sertraline can cause nausea and upset stomach, while green tea, due to its caffeine content, may lead to issues like acid reflux, heartburn, and even vomiting.

When used together, these gastrointestinal issues may become more pronounced and uncomfortable. (2,4)

Increased Risk of Bleeding

Both sertraline and green tea can affect blood clotting. Sertraline, as an antidepressant, can have anticoagulant properties, while green tea contains compounds like catechins that can interfere with blood clotting.

When combined, they may synergistically increase the risk of bleeding, leading to nosebleeds, easy bruising, or prolonged bleeding from minor cuts. (2,3)


Both sertraline and green tea can potentially disrupt sleep patterns. Sertraline may cause insomnia as a side effect in the initial phase of treatment, and green tea, again due to its caffeine content, can lead to difficulty falling asleep or staying asleep when consumed close to bedtime. (5,6)

Some patient groups at higher risk of side effects include:

  • Patients with bleeding disorders like Haemophilia
  • Elderly patients with chronic comorbidities
  • Patients regularly using NSAIDs for arthritis or joint pain
  • Patients with stomach ulcers, liver, or kidney problems
  • Higher Zoloft doses may increase the risk of green tea interaction
  • Prolonged use of both substances can amplify potential interactions

Consider these potential side effects and consult your healthcare provider before using both substances. Your healthcare provider can offer guidance based on your specific health status and medication regimen to ensure your safety and well-being.

What to do if sertraline interacts with green tea?

If you are concerned about interactions between green tea and Sertraline, follow these safety tips

  • Before using green tea or any herbal supplements alongside sertraline, talk to your healthcare provider.
  • Reduce or eliminate green tea while taking sertraline to minimise potential interactions.
  • Avoid excessive caffeine consumption, as it can amplify sertraline’s side effects.
  • Stay away from foods that can interact with Sertraline like cheese, avocados, and soybeans, which can interact with sertraline and raise blood pressure.
  • Discuss medication dosage adjustments with a healthcare provider to address bleeding concerns.


In summary, the combination of green tea and sertraline can indeed lead to drug-herb interactions. To mitigate the potential risks of this combination, it is advisable to either limit or avoid consuming green tea while taking sertraline. This caution is primarily rooted in the increased risk of bleeding, potential insomnia, and the likelihood of experiencing gastrointestinal side effects when both substances are used concurrently.

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