Does Fluvoxamine interact with Risperidone? (3 risks)

In this article, we will discuss whether Fluvoxamine can interact with Risperidone. We will also discuss the potential risks associated with this combination and how to ensure the safe and effective use of this combination.

Does Fluvoxamine interact with Risperidone?

Fluvoxamine can interact with Risperidone, and it is important to be cautious while taking them together.

Fluvoxamine and Risperidone belong to a different class of medications, but both tackle mental health conditions. When taken together you may experience potential interactions and side effects.

Fluvoxamine is a selective serotonin reuptake inhibitor prescribed for anxiety and depression (1). Risperidone, on the other hand, is an antipsychotic medication used for treating bipolar disorder and schizophrenia (2).

Both medications can increase the levels of serotonin in the brain, and the combination may lead to potential interactions.

If your healthcare provider prescribes both Fluvoxamine and Risperodone, they will carefully monitor you for any signs of drug interactions.

What does research suggest?

There is limited research available on the interaction between Risperidone and Fluvoxamine. However, one study justifies the use of Risperidone along with Fluvoxamine. It indicated that low doses of Risperidone, as low as 0.5mg, show efficacy in individuals with obsessive-compulsive disorder in individuals who did not respond to a standard treatment of Fluvoxamine alone (3).

Risperidone, an atypical antipsychotic, is added in some cases to enhance the treatment response, especially when OCD symptoms are severe or not adequately controlled with an SSRI alone.

Another study also stated that starting antidepressant therapy with a combination of Risperidone and Fluvoxamine enhances the rate of therapeutic response in individuals with depression (4).

What are the potential risks of combining Fluvoxamine and Risperidone?

Concomitant use of Fluvoxamine or any other antidepressant, such as Sertraline or Escitalopram, along with Risperidone can cause adverse consequences due to their effect on the brain and heart. Unless prescribed by your doctor and determined safe, the combined use of these drugs can cause the following risks to your health.

Serotonin syndrome 

Serotonin syndrome is a serious condition that occurs because of serotonin excess in the brain. It can be life-threatening (5).

Serotonin is a neurotransmitter responsible for regulating mood and reducing anxiety. When medications affecting serotonin levels in the brain are combined, such as the combined use of Fluvoxamine and Risperidone the risk of serotonin syndrome is high.

Serotonin syndrome can present with a range of signs and symptoms, including (5):

  • Hallucination
  • Agitation
  • Muscle twitching
  • High-grade fever
  • Excessive sweating
  • High blood pressure
  • Tremors
  • Seizures
  • Restlessness
  • Insomnia
  • Confusion

Life-threatening symptoms that need immediate intervention are tremors, high-grade fever and seizures. Although serotonin syndrome is a rare side effect, it can be lethal to a patient. It is essential to be aware of its early signs to prevent the worsening of your condition.

QT prolongation

The length of the QT interval will lead to irregular heart rhythm or arrhythmia. It is a rare side effect but can occur with many associated drugs. Antipsychotics such as Risperidone have a lower risk at therapeutic doses.

However, SSRIs have a high risk of affecting corrected QT (QTc) prolongation. Therefore, if you are taking both these drugs, you should discuss with your healthcare provider your risk of developing QTc prolongation (6).

Signs of QTc prolongation include (6):

  • Irregular heart rhythms
  • Palpitations
  • Dizziness
  • Lightheadedness
  • Fainting (Syncope)
  • Shortness of breath

Increased sedation

Fluvoxamine and Risperidone both act on the brain and have their own side effects. Both these medications are associated with the tendency to induce drowsiness. When taken together they may exacerbate the sedative effects, which may cause tiredness, sleepiness, dizziness and difficulty focusing.

What are the benefits of combining Fluvoxamine and Risperidone?

Combining Fluvoxamine and Risperidone may be considered in some cases to address specific mental health conditions. Both medications have different mechanisms of action and can complement each other in the treatment of certain psychiatric disorders.

Here are some potential benefits associated with the combination:

Management of anxiety and psychotic symptoms

Risperidone, as an antipsychotic, is used to manage psychotic symptoms. When anxiety or obsessive-compulsive features are present alongside psychosis, the combination with Fluvoxamine may help address both aspects of the mental health condition.

Augmentation of antidepressant effects

Risperidone is sometimes used as an adjunct to SSRIs in the treatment of depression, especially when depressive symptoms are not fully responsive to SSRIs alone. The combination may provide additional relief from depressive symptoms.

It is important to note that the combination of Fluvoxamine and Risperidone is typically reserved for specific cases, and the decision to use these medications together should be carefully considered by a healthcare professional.

What precautions should you take with Fluvoxamine and Risperidone?

Since the combination of Fluvoxamine and Risperidone can lead to serious drug interactions, take them only if your doctor finds it necessary. Medical supervision will be crucial in reducing any complications.

Remember the following precautions while taking both medications.

  • Consult your doctor for medical attention and dose adjustment.
  • Be vigilant for potential side effects.
  • If you have pre-existing heart conditions while taking Fluvoxamine and Risperidone, regularly monitor and follow up with your doctor.
  • Avoid driving or operating heavy machinery when feeling dizzy or drowsy.
  • Avoid alcohol and caffeine intake. It causes complications while taking antidepressants and antipsychotics.
  • Inform your doctor if you are pregnant or planning to get pregnant before taking Fluvoxamine and Risperidone (7,8).

How to ensure the safe use of Fluvoxamine and Risperidone together?

Remember the following points to ensure the safe use of Fluvoxamine and Risperidone:

  • Always take the medications as prescribed by your doctor.
  • Discuss your medical history and the medications you take with your doctor.
  • Ask your doctor about the benefits and risks of your treatment plan.
  • Consult your doctor before starting or stopping any medication.
  • Follow up with your doctor regularly about the side effects you experience.


In my experience, Fluvoxamine and Risperidone can interact, and their combination should be approached with caution. 

I suggest patients should always inform their healthcare providers about all medications they are taking, and any concerns about drug interactions should be discussed to ensure safe and effective treatment.





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