Does Fluvoxamine Interact With Ibuprofen? (3+ Interactions)

By Ivan Kahwa

Page last updated: 05/02/2024 | Next review date: 05/02/2026

Author bio

Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.

Mr Ivan Kahwa’s Highlights:

Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.

Professional Experience:

Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.

With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.

With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.

Education:

2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.

2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.

2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.

Publications:

▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7

▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60

▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.

https://ethnobotanyjournal.org/index.php/era/article/view/4683

▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.

https://doi.org/10.53388/TMRIM202307004

▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.

https://doi.org/10.1186/s43094-021-00296-2

▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.

https://doi.org/10.5799/jmid.951600

Published book Chapter

▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.

https://doi.org/10.1016/B978-0-323-91942-5.00012-4

Submitted manuscripts Under Review:

▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience

▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine

▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology

Submitted book chapters under review

1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.

2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press

You can view my works on the following professional sites:

Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa

Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en

ORCID: https://orcid.org/0000-0002-6440-3437

Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159

Ivan Kahwa

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In this article, we will discuss whether fluvoxamine interacts with ibuprofen or not. We will also discuss what research suggests on this, the possible interactions between fluvoxamine and ibuprofen and precautions for taking both these medications together.

Does fluvoxamine interact with ibuprofen?

Yes, fluvoxamine and ibuprofen can interact with each other and it’s important to be cautious when taking them together.

Fluvoxamine inhibits a liver enzyme called CYP2C19, which is involved in the metabolism of various medications, including ibuprofen. When fluvoxamine inhibits this enzyme, it increases the levels of ibuprofen in the body. (1)

Both medications also independently raise the risk of bleeding, so combining them increases the risk even more. It’s crucial to let your doctor know about all the medications you’re taking, including over-the-counter ones like ibuprofen. They can give you personalized advice based on your medical history. (2)

What does research suggest?

According to a research study, Zullino and Khazaal point out that both NSAIDs and SSRIs (like fluvoxamine) can affect how blood platelets come together, increasing the chances of gastric problems. (3)

There might not be extensive research specifically focused on the interaction between fluvoxamine and ibuprofen. However, both medications are known to affect certain enzymes in the liver which can potentially lead to interactions. (1,2)

Always consult with your healthcare provider or check the latest medical literature for the most current information on drug interactions, especially if considering or taking a combination of medications.

What are the potential interactions between fluvoxamine and ibuprofen?

Fluvoxamine and ibuprofen can interact and it’s important to be aware of potential interactions due to their effects on certain enzymes in the body. Here are some considerations: (4,5)

Enzyme inhibition: Fluvoxamine inhibits the activity of an enzyme in the liver that is involved in the metabolism of various drugs, including ibuprofen. Inhibition of this enzyme by fluvoxamine may lead to increased levels of ibuprofen in the body.

Increased risk of side effects: Elevated levels of ibuprofen may increase the risk of side effects especially when combined with fluvoxamine. It could raise the risk of stomach problems like bleeding or developing ulcers. (4,5)

Bleeding risk: Both fluvoxamine and ibuprofen when taken separately can increase the risk of bleeding. If you take them together, especially in higher amounts the risk of bleeding may be further heightened. (5)

Individual variation: The degree of interaction varies among individuals based on certain factors like genetics, overall health and the specific dosage of each medication.

It’s important to be careful and let your doctor know if you’re thinking about taking these medications together. They can help you find a safe way to manage your symptoms.

What is the best way to take fluvoxamine and ibuprofen together?

If your doctor has prescribed both fluvoxamine and ibuprofen together, here are some general guidelines: (1,2,5)

Follow your doctor’s instructions: Always take medications exactly as prescribed by your doctor. If your doctor has recommended taking fluvoxamine and ibuprofen together, follow their instructions carefully.
Take with food or milk: Taking ibuprofen with food or milk can reduce the risk of stomach upset.
Regular checkups: Keep your healthcare provider informed about any side effects or changes in your condition. They can monitor your progress and make adjustments to your medication regimen if necessary.
Avoid self-adjusting dosages: Don’t adjust the dosages or stop taking medication on your own as it can have withdrawal side effects.
Inform your pharmacist: When picking up your prescription, inform your pharmacist about all the medications you are taking including over-the-counter drugs and supplements.

Always consult with your healthcare provider for advice related to your specific health conditions and needs.

In my opinion, it is essential to follow the prescribed dosages, report any side effects promptly and maintain regular check-ins with your healthcare professional for the best therapeutic outcome.