Does Effexor withdrawal cause diarrhea? (+5 management tips)
By
Dr Drielli Vital-Fujii (PhD)
Author bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
In this article, we will discuss whether Effexor withdrawal causes diarrhea. We will also explore some scientific studies on the link between Effexor and diarrhea and the management of diarrhea associated with Effexor withdrawal. Additionally, we will discuss the other withdrawal effects of Effexor.
Does Effexor withdrawal cause diarrhea?
Yes. Effexor withdrawal does cause diarrhea. Effexor withdrawal symptoms can differ from person to person and may include gastrointestinal issues like diarrhea, as well as symptoms like dizziness, headache, fatigue, nausea, irritability, and flu-like symptoms. It is crucial to gradually taper off Effexor under the supervision of a healthcare professional to minimize the risk and severity of withdrawal symptoms.
Effexor (venlafaxine) is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant medication. It is frequently prescribed to address mental disorders such as major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder (1).
It is important to know that like any other medication, Effexor can cause various side effects including nausea, vomiting, dizziness, and insomnia, and abrupt discontinuation of this medication can lead to withdrawal symptoms. Therefore, it is essential to take Effexor only under the supervision of a healthcare professional. Any modifications to the dosage or discontinuation should be carried out only with their guidance.
How does Effexor withdrawal cause diarrhea?
The mechanism by which Effexor withdrawal may cause diarrhea is linked to its effects on the levels of serotonin in the brain. Increased levels of serotonin also help to regulate bowel movements and peristalsis. Abrupt Effexor withdrawal can cause a sudden decrease in serotonin levels and can disrupt the normal functioning of the digestive system which may lead to increased bowel motility and fluid secretion, contributing to diarrhea (6).
It is crucial to note that individual responses to Effexor withdrawal can vary, and not everyone experiences diarrhea during its withdrawal. However, gradual tapering under the supervision of a healthcare professional is often recommended to reduce withdrawal symptoms associated with Effexor.
What does research suggest?
Research shows that Effexor can cause several withdrawal symptoms, such as diarrhea, dizziness, agitation, sweating, insomnia, and nausea. These symptoms can occur in individuals if they abruptly stop taking Effexor or reduce their dosage. However, these symptoms can be avoided by gradually tapering off the dose of Effexor for a period of one week to 10 days before discontinuing use (2).
A research study demonstrated that 75% of individuals reported somatic symptoms after Effexor withdrawal, including diarrhea, nausea, vomiting, headache, and fatigue. Sleep disturbances were mentioned by 44%, and cognitive impairments were reported by 32% of individuals (5).
According to a research study, withdrawal symptoms including diarrhea, after abrupt discontinuation of Effexor occurred in 57% (six cases) of patients. Additionally, a separate research study reported a case where severe diarrhea occurred in a woman following the discontinuation of venlafaxine. This patient also experienced other withdrawal effects such as nausea, vomiting, headache, and insomnia (3).
Another study suggested that discontinuing the use of Effexor can cause not only physical and gastrointestinal withdrawal effects such as diarrhea but also psychiatric symptoms. A case study demonstrated that an elderly woman who had been taking venlafaxine 225mg for a year experienced withdrawal effects of Effexor including diarrhea (4).
What to do if diarrhea occurs after Effexor withdrawal?
If diarrhea occurs after discontinuation of Effexor, consult with your healthcare provider for guidance and a personalized treatment plan to minimize these effects. The effective management of Effexor withdrawal-induced diarrhea may involve the following tips:
- Discontinuation of Effexor should be done by slowly tapering off the Effexor dose under the supervision of a healthcare professional. This helps to reduce withdrawal symptoms of Effexor, including diarrhea.
- Adequate hydration and drinking plenty of fluids are essential to prevent dehydration and replace lost electrolytes. Drinking water, clear broths, and oral rehydration solutions can be beneficial.
- To help control diarrhea symptoms, your healthcare provider may recommend over-the-counter anti-diarrheal medications such as loperamide (Imodium). However, it’s crucial to consult with them before using any medications.
- It’s important to be mindful of your symptoms and discuss them regularly with your healthcare provider. If the diarrhea persists or becomes severe, seek prompt medical attention.
- To avoid worsening diarrhea, it’s recommended to avoid certain foods and beverages such as caffeine, dairy, spicy foods, and high-fat foods. Opt for a bland and easily digestible diet instead.
It is crucial to avoid making any changes to your medication regimen or trying to manage withdrawal symptoms on your own without first consulting with your healthcare provider. It is important to always adhere to your healthcare provider’s instructions for a safe and efficient withdrawal process.
What are the other withdrawal effects of Effexor?
Apart from diarrhea, Effexor withdrawal may also lead to other potentially serious adverse effects such as (2):
- tremors
- stroke
- dizziness
- drowsiness
- vertigo
- xerostomia
- manic symptoms
- aggression
- nervousness
- tiredness
- headaches
- sleep disturbances
- excessive sweating
- anxiety
- appetite disturbances
It’s important to note that not all individuals who discontinue Effexor may experience withdrawal symptoms, as these can vary based on individual factors and underlying health conditions.
Conclusion
To my knowledge, Effexor withdrawal can lead to gastrointestinal symptoms including diarrhea, vomiting, and GIT discomfort. It is essential to consult your healthcare provider to effectively manage these symptoms.
Your healthcare provider may guide you to gradually taper the medication under his supervision. Additionally, lifestyle and dietary modifications including adequate hydration and reducing spicy food intake and, in some cases, OTC medications can help alleviate diarrhea and other gastrointestinal symptoms.
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References
1.-
Singh D, Saadabadi A. Venlafaxine. [Updated 2022 Oct 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535363/
2.-
Campagne DM. Venlafaxine and serious withdrawal symptoms: warning to drivers. MedGenMed. 2005 Jul 6;7(3):22. PMID: 16369248; PMCID: PMC1681629. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681629/
3.-
Bet PM, Köktaş IO, Bergh M. Stoppen met venlafaxine door omzetting naar fluoxetine [Discontinuing venlafaxine by switching to fluoxetine]. Tijdschr Psychiatr. 2018;60(11):782-785. Dutch. PMID: 30484571. https://pubmed.ncbi.nlm.nih.gov/30484571/
4.-
Sabljić V, Ružić K, Rakun R. Venlafaxine withdrawal syndrome. Psychiatr Danub. 2011 Mar;23(1):117-9. PMID: 21448114. https://pubmed.ncbi.nlm.nih.gov/21448114/
5.-
Hengartner, Michael & Schulthess, Lukas & Sorensen, Anders & Framer, Adele. (2020). Protracted withdrawal syndrome after stopping antidepressants: a descriptive quantitative analysis of consumer narratives from a large internet forum. Therapeutic Advances in Psychopharmacology. 10. 204512532098057. 10.1177/2045125320980573.
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