Does Desvenlafaxine cause photosensitivity? (+3 factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss photosensitivity associated with the use of Desvenlafaxine. We will also discuss the mechanisms, symptoms and management of Desvenlafaxine-induced photosensitivity.
Does Desvenlafaxine cause photosensitivity?
Yes, Desvenlafaxine can cause photosensitivity in some individuals. However, the photosensitive reactions associated with Desvenlafaxine are not very frequent.
Photosensitivity is a side effect in which a person’s skin becomes more sensitive to sunlight or ultraviolet (UV) radiation while taking the medication. This increased sensitivity can lead to an increased risk of sunburn or skin damage when exposed to the sun.
Desvenlafaxine, an SNRI, is a prescription medication used to treat conditions such as depression and anxiety. It is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI) and works by affecting the balance of certain neurotransmitters in the brain (1).
If you feel Desvenlafaxine is causing photosensitive reactions, it is important to reach out to your healthcare provider.
How does Denvenlafaxine cause photosensitivity?
The exact mechanism of Desvenlafaxine-induced photosensitivity is not well documented. However, it is suggested that the drug or its metabolites may make the skin more sensitive to UV radiation from the sun. The increased sensitivity can result in a greater risk of sunburn and other skin reactions (2).
It may be related to the drug’s effect on neurotransmitters in the brain, such as serotonin and norepinephrine, which can affect various physiological processes in the body, including skin responses to UV radiation (2).
However, the specific mechanisms and pathways involved are not fully understood, and the exact cause of photosensitivity as a side effect of Desvenlafaxine may vary from person to person.
What are the symptoms of Desvenlafaxine-induced photosensitivity?
The symptoms of Desvenlafaxine-induced photosensitivity can vary from person to person. The most common symptom associated with drug-induced photosensitivity is erythema. However, other symptoms associated with Desvenlafaxine-induced photosensitivity include (3):
- Swelling
- Sunburn
- Itching
- Pustules
- Eczema
- Edema
- Rash
- Redness
- Pigmentation
It is essential to be vigilant about these symptoms and take precautions to protect your skin from UV exposure while taking Desvenlafaxine.
In the physical evaluation of patients suffering from photosensitivity, it was observed that sun-exposed areas of the body, such as the face, neck and hands show more damage.
It is important to contact your healthcare provider if you experience any symptoms mentioned above while using Desvenlafaxine or any other antidepressant such as Sertraline, Venlafaxine, Citalopram etc.
What factors can contribute to Desvenlafaxine-induced photosensitivity?
Several factors can contribute to Desvenlafaxine-induced photosensitivity. These include:
Higher doses: Higher doses and prolonged use of Desvenlafaxine may increase the risk of various side effects including photosensitivity and other skin-related issues.
Individual response: Some individuals are more susceptible to the side effects of Desvenlafaxine including photosensitivity because of their sensitive skin and other genetic factors. Individual responses to medications vary, and some people might be more sensitive to sunlight than others.
Age: Older adults are associated with an increased risk of Desvenlafaxine-induced photosensitivity.
Concurrent use of other medications: Concurrent use of other medications or substances along with Desvenlafaxine that are known to cause photosensitivity can potentiate Desvenlafaxine-induced photosensitivity, enhancing the overall effect.
Lifestyle factors: Direct exposure to sunlight or UV light, especially for a prolonged period and inadequate sun protection during outdoor activities increase the risk of photosensitivity induced by Desvenlafaxine.
It is important for individuals taking Desvenlafaxine to be aware of these factors and consult with a healthcare professional for personalized guidance.
How to manage Desvenlafaxine-induced photosensitivity?
To manage Desvenlafaxine-induced photosensitivity following steps should be taken:
- Applying sunscreen with an SPF of 30 or higher to all exposed skin areas, even in cloudy weather.
- Apply sunscreen even if you are swimming.
- Avoid standing in the sun, especially during the middle of the day.
- Wear protective clothing, such as a full-sleeved shirt, pants and a hat.
- Use a moisturizer that contains titanium dioxide or zinc oxide, as these can help to protect the skin from UV rays (4).
- Be vigilant about changes in your skin and promptly report any new or concerning skin issues to your healthcare provider.
- If you have a history of skin problems, your healthcare provider may refer you to a dermatologist for specialized care and advice.
Based on my knowledge and experience, it is clear that Desvenlafaxine can cause photosensitivity. However, individual responses to medications vary. If you suspect Desvenlafaxine-induced photosensitivity, it is important to reach out to your healthcare provider for individualized guidance and treatment plans.
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