Does Cymbalta help pelvic pain? (+5 alternatives)

In this article, we will discuss the role of Cymbalta in the management of pelvic pain. We will also discuss the research studies suggesting the effectiveness of Cymbalta in pelvic pain, as well as the alternative mediations for managing pelvic pain if Cymbalta fails to treat it. 

Does Cymbalta help pelvic pain?

Yes, Cymbalta does help pelvic pain. While the exact mechanism of Cymbalta in pain management remains unclear, recent studies have explored its potential as an effective medication for pelvic pain (4).

Cymbalta is an antidepressant medication frequently employed in the treatment of depression, fibromyalgia, and anxiety. Research studies have also reported its potential to be used in the management of back pain, joint pain, and pelvic pain (1).

While it is generally considered a safe medication that is well-tolerated by individuals, it may cause certain side effects in some, such as dizziness, tiredness, drowsiness, headache, vomiting, and appetite and weight changes (1).

What is the dosage of Cymbalta for pelvic pain?

The recommended dosage for Cymbalta in the treatment of pelvic pain is typically 60mg daily. However, it’s important to note that the duration of treatment can vary from person to person. Studies indicate that individuals may experience relief from pelvic pain with Cymbalta after a few weeks to months of consistent use (2).

While the response to treatment varies, research suggests that a duration of approximately 4 months may be beneficial for managing pelvic pain effectively (2). Individuals must follow their healthcare provider’s guidance regarding the dosage and duration of Cymbalta therapy, as adjustments may be made based on the individual’s response and overall health.

What does research suggest?

In a research study, Cymbalta was employed as part of the management strategy for pelvic pain, administered at a dosage of 60 mg daily, in combination with doxazosin. The study aimed to assess the effectiveness of this combination in alleviating pelvic pain symptoms.

Results showed a gradual improvement, with 30% experiencing relief after 4 weeks. The effectiveness increased over time, and after 24 weeks, about 89% of patients showed significant improvement in pelvic pain (3). 

 In an additional research study, the use of Cymbalta showcased its effectiveness in addressing pelvic pain among elderly patients. This positive outcome was achieved when Cymbalta was employed in combination with olanzapine, suggesting a synergistic approach to pain management in patients with chronic pelvic pain syndrome (4). 

What to do if Cymbalta fails to manage pelvic pain?

Treatment with Cymbalta usually takes a few weeks to show improvement in your symptoms. However, if you find that Cymbalta is not relieving your pelvic pain even after weeks of treatment, you should consult your healthcare provider. They will assess your condition and determine the cause of treatment failure.

In some cases, increasing the dosage of Cymbalta is helpful in achieving therapeutic outcomes. However, you should be cautious while using a higher dosage of Cymbalta, as it may increase the likelihood of side effects associated with the medication.

Alternatively, your healthcare provider may recommend an alternative to Cymbalta for managing your pelvic pain. It is important to note that discontinuation of Cymbalta should be done under the guidance of your healthcare provider to avoid unwanted side effects associated with the sudden discontinuation of this medication.

What are the alternatives to Cymbalta for pelvic pain?

If Cymbalta proves ineffective in managing pelvic pain symptoms, your healthcare provider may prescribe alternative medications based on the underlying cause and severity of the pain. These alternatives may include (5,6,7):

  • fluoxetine
  • citalopram
  • venlafaxine
  • mirtazapine
  • anticonvulsants (gabapentin, pregabalin)

However, it is crucial to consult with a healthcare professional for a proper diagnosis and a personalized treatment plan. These medications may have potential side effects, and the selection of an appropriate medication should be based on an assessment of their risks and benefits. 

 In my opinion, Cymbalta is a good option for managing pelvic pain, considering its safety and efficacy profile. It is less likely to cause unwanted and serious side effects in individuals. However, you should not take any medication without consulting your healthcare provider.

Always discuss your symptoms with your healthcare provider to ensure the most suitable and effective treatment for your specific condition.

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Bi, Bo & Shan, Liping & Zhou, Die. (2018). Combined Use of Duloxetine and Olanzapine in the Treatment of Urologic Chronic Pelvic Pain Syndromes Refractory to Conventional Treatment: A Case Report. Clinical Psychopharmacology and Neuroscience. 16. 122-125. 10.9758/cpn.2018.16.1.122.


Karp JF. Venlafaxine XR and chronic pelvic pain syndrome. J Clin Psychiatry. 2004 Jun;65(6):880-1. doi: 10.4088/jcp.v65n0622e. PMID: 15291672.


Xia D, Wang P, Chen J, Wang S, Jiang H. Fluoxetine ameliorates symptoms of refractory chronic prostatitis/chronic pelvic pain syndrome. Chin Med J (Engl). 2011 Jul;124(14):2158-61. PMID: 21933619.


Brown CS, Franks AS, Wan J, Ling FW. Citalopram in the treatment of women with chronic pelvic pain: an open-label trial. J Reprod Med. 2008 Mar;53(3):191-5. PMID: 18441724.

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