Does Cymbalta contain duloxetine? (+5 strengths)

In this article, we will discuss the composition of Cymbalta’s formulation and explore its various strengths. Additionally, we’ll examine the therapeutic benefits it offers for managing specific health conditions, as well as discuss side effects associated with its use.

Does Cymbalta contain duloxetine?

Yes, Cymbalta does contain duloxetine. Duloxetine is an antidepressant medication marketed under various brand names, with Cymbalta being one of them. It is commonly used to manage various mental health disorders such as anxiety and depression.

The therapeutic effects of this medication arise from its impact on neurotransmitters in the brain, specifically serotonin and norepinephrine. By increasing their levels, Cymbalta helps elevate mood and reduce the sadness associated with depression and related disorders (1).

Generally, Cymbalta is considered a safe and effective medication. It can be used safely in the elderly without causing serious side effects. However, certain risk factors, such as underlying liver disease, higher dosage, and drug interactions, may lead to side effects in some individuals.

It’s important to use the medication under the guidance of a healthcare professional to minimize the unwanted effects and ensure its effectiveness.

What is the composition of Cymbalta formulation?

The formulation of Cymbalta contains duloxetine hydrochloride as an active ingredient, which is responsible for its therapeutic benefits. Along with the active ingredient, the formulation also contains inactive ingredients or excipients that are responsible for maintaining the stability of a dosage form and enhancing patient acceptability.

These inactive materials may include fillers, disintegrants, diluents, lubricants, and binders. Each excipient serves a different function, and overall, they help in the formulation of the final dosage form of an active ingredient that can be easily administered by a patient.

The exact composition of Cymbalta may vary from one manufacturer to another; however, the active ingredient remains the same in all formulations.

What are the available strengths of Cymbalta?

Cymbalta is available in a delayed-release capsules formulation, in various strengths including:

  • 20 mg
  • 30 mg
  • 40 mg
  • 60 mg
  • 90 mg

What does Cymbalta treat?

Cymbalta is an anti-depression medication that helps in the treatment of the following medical conditions and their associated symptoms (2):

  • depression
  • obsessive-compulsive disorder
  • anxiety
  • fibromyalgia
  • chronic back pain
  • panic attacks
  • social anxiety disorders
  • joint pain
  • muscle pain
  • arthritis pain
  • neuropathic pain
  • migraines

 The dosage and duration of Cymbalta treatment may vary among individuals based on the specific condition for which an individual is being treated. The typical dosage may range from 60 to 120 mg daily.

However, the dosage is initiated at a minimum dose to achieve therapeutic benefits with the least probability of side effects. Symptoms may start improving after 3 weeks of treatment, but the medication is continued until the complete alleviation of symptoms

What are the side effects of Cymbalta?

Cymbalta is generally considered a well-tolerated medication with a low incidence of serious side effects. However, it may cause some mild to moderate side effects, especially during the start of treatment when the body is adjusting to the medication. These side effects may include (1):

  • sleep disturbances
  • weight changes
  • gastrointestinal discomfort
  • stomach upset
  • drowsiness
  • vomiting
  • appetite changes
  • dizziness
  • tiredness
  • headaches
  • sedation
  • confusion
  • agitation
  • aggression
  • irritability
  • lightheadedness

It’s important to note that the side effects of Cymbalta usually subside as the body adjusts to the medication and may not require additional pharmacological treatment in most cases.  However, if you experience severe and persistent side effects of Cymbalta, you should contact your healthcare provider as soon as possible.

Individual factors such as sensitivity to duloxetine, the presence of liver disease, and the use of medications that may negatively interact with Cymbalta can increase the risk of serious effects in individuals taking this medication.

It is important to be vigilant about your symptoms and discuss them with your healthcare provider to ensure the safety of the treatment.

To my knowledge, Cymbalta, a brand name for duloxetine, is a commonly available medication in the market and is frequently prescribed in clinical settings for the management of various health conditions. It is a safe medication with a lower incidence of serious side effects.

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Dhaliwal JS, Spurling BC, Molla M. Duloxetine. [Updated 2023 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Knadler MP, Lobo E, Chappell J, Bergstrom R. Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94. doi: 10.2165/11539240-000000000-00000. PMID: 21366359.

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