Does Cymbalta contain aspirin? (+3 differences)

In this article, we will discuss whether the formulation of Cymbalta contains aspirin. We will also discuss the key differences between Cymbalta and aspirin, including their mechanism of action, uses, and side effects. 

Does Cymbalta contain aspirin?

No, Cymbalta does not contain aspirin. Cymbalta is the brand name for duloxetine, which is an antidepressant medication. Both Cymbalata and aspirin are completely different medications with different classes, mechanisms of action, and therapeutic uses. 

Cymbalta is commonly prescribed in clinical settings for the management of various mental conditions such as anxiety and depression. On the other hand, aspirin is an analgesic medication that helps in the alleviation of pain associated with headaches, menstrual cramps, and certain inflammatory conditions.

What does Cymbalta contain?

Duloxetine hydrochloride is the active ingredient in various commercially available formulations, including Cymbalta and other brands such as Yentreve. The active ingredient is generally present in strengths like 30 mg, 60 mg, and 90 mg, accompanied by distinct excipients or inactive ingredients (6).

These inactive components serve a vital function in stabilizing the ultimate dosage form of the medication, ensuring its physical integrity and uniformity, yet they do not contribute to the pharmacological effects.

It is emphasized that the amount and type of excipients may vary among different brands of duloxetine. However, none of the duloxetine formulations contain aspirin.

What are the differences between Cymbalta and aspirin?

Duloxetine and aspirin are different medications with distinct mechanisms of action, uses, and side effect profiles. Here are some key differences between the two:

Mechanism of action

Cymbalta and aspirin belong to different classes of drugs with different mechanisms of action. Cymbalta is an antidepressant medication that belongs to the class of serotonin and norepinephrine reuptake inhibitors. It works by increasing the levels of serotonin and norepinephrine in the brain by inhibiting their reuptake (1).

The elevated levels of these neurotransmitters are responsible for improving mood and regulating behavior in individuals with various mental health disorders.

On the other hand, aspirin is an analgesic medication that belongs to the class of nonsteroidal anti-inflammatory drugs. It works by inhibiting the activity of cyclooxygenase enzymes that are responsible for the release of prostaglandins that promote inflammation and pain (3).

Aspirin, by inhibiting these enzymes, contributes to the reduction of inflammation and pain sensation throughout the body.


Cymbalta is commonly indicated in the management of various medical conditions such as (2),

  • depression
  • social anxiety
  • panic disorders 
  • fibromyalgia
  • joint pain
  • muscle aches
  • migraines
  • chronic back pain
  • arthritis pain
  • generalized anxiety

On the other hand, aspirin is indicated in the management of the following conditions (3):

  • fever
  • headaches
  • toothaches
  • menstrual cramps
  • arthritis
  • heart attacks
  • stroke
  • deep vein thrombosis
  • pulmonary embolism

 It’s important to note that while aspirin has various indications, it should be used only under the guidance of a healthcare professional. The dose of aspirin should not be altered without the direction of a healthcare provider, as it may lead to unwanted side effects and reduced therapeutic efficacy.  

Side effects

Cymbalta is generally associated with a lower incidence of serious side effects, however, it may cause mild to moderate side effects in some individuals such as (1),

  • nausea
  • vomiting
  • diarrhea
  • dizziness
  • drowsiness
  • agitation
  • aggression
  • confusion
  • irritability
  • sleep disturbances
  • appetite changes
  • weight changes

On the other hand, the side effects associated with the use of aspirin may include (4):

  • heartburn
  • indigestion
  • nausea
  • gastrointestinal bleeding
  • tinnitus
  • kidney problems
  • gastric ulcers
  • hypersensitivity reactions

 It’s important to use aspirin as directed by a healthcare professional and to be aware of potential side effects. Additionally, the potential risks and benefits of aspirin should be carefully considered, before starting this medication to avoid unwanted side effects. 

Can you combine Cymbalta with aspirin?

Combining Cymbalta and aspirin should be approached cautiously and under the supervision of a healthcare professional to prevent serious side effects. The decision to combine these medications may depend on the specific underlying condition and the comprehensive treatment plan.

In certain situations, a healthcare provider may find it necessary to combine aspirin and Cymbalta for managing conditions that encompass both pain and a cardiovascular component. However, before considering this combination, it is crucial to assess the individual’s medical history, overall health, and any pre-existing conditions.

Given that both medications can influence blood clotting, combining them may elevate the risk of bleeding (5). Therefore, individuals are strongly advised to consult with their healthcare provider to discuss their individual health status and the appropriateness of combining aspirin and Cymbalta for their specific situation.

To my knowledge, formulations of Cymbalta do not include aspirin. It’s important to note that aspirin and Cymbalta are distinct medications utilized for different purposes in individuals. However, if someone is taking both medicines at the same time, healthcare professionals will consider their medical history, current medications, and overall health before making informed decisions about their treatment plan.

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