Does Celexa interact with Gabapentin? (+3 Precautions)
This article will discuss the query, “Does Celexa interact with Gabapentin?” We will also have a closer look at the potential interactions between Celexa and Gabapentin and precautions to avoid the side effects of this interaction.
Does Celexa interact with Gabapentin?
Yes, Celexa and Gabapentin do have a possible interaction. When used in combination, the severity of adverse effects may increase (1). However, this interaction often occurs when both medications are prescribed at a high dose.
Gabapentin is an anticonvulsive medication used to treat post-herpetic neuralgia, partial-onset seizures, and restless leg syndrome (2). While Celexa (Citalopram) is an SSRI antidepressant primarily used to treat depression in adults (3)
When used together, these drugs can lead to potentially serious interactions. Therefore, it is recommended that healthcare providers should cautiously prescribe Celexa and Gabapentin together.
What are the possible interactions between Celexa and Gabapentin?
The potential interactions between Celexa and Gabapentin include the following:
A rare side effect associated with using SSRIs such as Celexa is hyponatremia, in which there is a drop in your blood sodium levels. When Celexa is co-administered with an anticonvulsive medication such as Gabapentin, the risk of the severity of hyponatremia may increase (3).
If you experience any of the symptoms of hyponatremia, which include headache, difficulty concentrating, memory impairment, confusion, and weakness while taking Celexa and Gabapentin together, it is recommended to contact your healthcare provider immediately (3)
In more severe cases, hyponatremia may lead to hallucinations, syncope, seizures, coma, respiratory distress, or even death (3).
Celexa should be used cautiously in patients with seizure disorders, as some clinical studies have indicated that 0.3% of the patients treated with Celexa develop seizures (3).
Therefore, using Gabapentin with Celexa might reduce its efficacy, leading to an increased risk of seizures in susceptible individuals.
If you experience seizures or an increase in the frequency of seizures while taking Celexa with Gabapentin, it is recommended that you contact your healthcare provider immediately.
Healthcare Provider’s role in Celexa-Gabapentin interaction management
Your healthcare provider plays a significant role in preventing and managing the interaction between Celexa and Gabapentin.
If you experience any symptoms of hyponatremia or seizures while taking Celexa and Gabapentin together, it is strongly recommended that you immediately contact your healthcare provider.
Your healthcare provider should also inform you about the possible adverse effects associated with Gabapentin and Celexa and advise you to promptly report any worsening of your depression symptoms or any changes in your mood and behavior (4,5).
To manage the risk associated with taking Celexa and Gabpentin together, your healthcare provider will either adjust the dose of your medicines or switch you to other medications that do not have a possible interaction with one another.
How to minimize Celexa and Gabapentin interaction side effects?
To minimize the side effects associated with the interaction between Celexa and Gabapentin, it is recommended to take the following precautions:
- Do not drive or operate hazardous machinery while taking Celexa and Gabapentin together, as these medications tend to cause drowsiness and loss of coordination (2,3).
- To avoid hyponatremia associated with the concomitant use of Celexa and Gabapentin, monitoring your sodium levels regularly is recommended, especially when both medications are prescribed at high doses.
- Both Celexa and Gabapentin have an interaction with alcohol that results in CNS depression. Therefore, it is recommended to avoid alcohol when using Celexa with Gabapentin (2,3).
- Do not abruptly stop Celexa or Gabapentin without consulting your healthcare provider, as discontinuing these medications abruptly can often lead to withdrawal symptoms.
In this article, we have discussed the query, “Does Celexa interact with Gabapentin?” We have also discussed the potential interactions between Celexa and Gabapentin and the precautions to avoid the side effects of this interaction.
Was this helpful?
PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3446, Gabapentin; [cited 2023 Oct. 6].
Gabapentin: MedlinePlus Drug Information. (n.d.).
Citalopram: MedlinePlus Drug Information. (n.d.).
The Food and Drug Administration (FDA).HIGHLIGHTS OF PRESCRIBING INFORMATION. CELEXA (citalopram) tablets, for oral use. Available from:
The Food and Drug Administration (FDA).HIGHLIGHTS OF PRESCRIBING INFORMATION. NEURONTIN (gabapentin) capsules, for oral use. Available from: