Does Celexa help with neuropathy? (+5 medications)

In this article, we will discuss whether Celexa helps with neuropathy. We will also discuss the research the studies linking the use of Celexa in the management of neuropathic pain. Additionally, we will discuss alternative medications for managing neuropathy if Celexa fails to be effective. Lastly, we will provide management tips for individuals with underlying neuropathy.

Does Celexa help with neuropathy?

Yes, Celexa does help with neuropathy. Some studies and clinical trials have investigated the potential use of certain antidepressants like Celexa, in managing neuropathic pain. These medications might be prescribed off-label to alleviate neuropathic symptoms in certain cases (1).

Consultation with a healthcare professional is essential to discuss the appropriateness of using Celexa for your specific neuropathy condition, as they can offer personalized advice based on your medical history and symptoms.

What does research suggest?

According to research, Celexa has demonstrated the ability to manage symptoms of neuropathy, including neuropathic pain.

In a study, Celexa was employed to address neuropathy in individuals with pre-existing diabetes. The findings indicated symptom improvement after a few weeks of Celexa treatment. However, approximately 10% of individuals could not complete the treatment due to the occurrence of side effects (2).

In another study, the effectiveness of Celexa in managing neuropathy symptoms was compared with gabapentin. The results revealed a significant improvement of more than 45% in individuals taking Celexa. These outcomes were comparable to those of gabapentin, where over 55% of patients reported improvement in symptoms (3).

The study suggests that Celexa could potentially serve as an alternative to gabapentin for patients with neuropathy (3).

What to do if Celexa fails to manage neuropathy?

If Celexa fails to effectively manage neuropathy or neuropathic pain, it’s important to consult with your healthcare provider to discuss alternative treatment options. Your healthcare provider may reassess your condition to ensure an accurate diagnosis and determine if any adjustments need to be made to your treatment plan.

They may explore other medications that are specifically designed for neuropathic pain, depending on the underlying cause of neuropathy. It is important to note that when transitioning from Celexa to another medication or when discontinuing it, it’s crucial to follow the guidance of a healthcare professional.

They can create a tapering schedule, gradually reducing the dosage over time to minimize the risk of withdrawal symptoms and ensure a smooth transition to a new medication or treatment plan.

What other medication can help with neuropathy?

Neuropathy can be managed with various medications and the choice of a specific medication depends on the underlying cause of neuropathy and the specific symptoms. Here are some classes of medications commonly used for neuropathy (4):   








Topical medications Lidocaine patches
Pain medications   Opioid analgesics
Nerve stabilizing medications  Alpha-lipoic acid

What are the management tips for neuropathy?

In addition to pharmacological treatments, healthcare providers also emphasize non-pharmacological approaches to enhance the quality of life for individuals with neuropathy. Some of the management tips for such patients may include:

  • Maintain a healthy diet rich in vitamins and minerals.
  • Control blood sugar levels if you have diabetes.
  • Stay hydrated to support nerve function.
  • Limit alcohol consumption, as excessive alcohol can damage nerves.
  • Manage stress through techniques such as meditation or deep breathing exercises.
  • Avoid walking barefoot to prevent injuries.
  • Avoid prolonged exposure to hot water, as it can worsen symptoms.
  • Include antioxidant-rich foods in your diet.
  • Biofeedback techniques can help manage pain.
  • Acupuncture may provide relief for some individuals.
  • Wear loose clothing to prevent compression on nerves.
  • Consider devices such as canes or walkers for stability.
  • Ensure adequate and quality sleep. 

In my experience

In my experience, the utilization of Celexa for symptomatic management of neuropathy is less common in clinical settings due to the availability of more effective options for such patients. Healthcare providers often prioritize prescribing anticonvulsants like gabapentin for neuropathy management.

However, the choice of medication can vary among individuals based on their specific condition and the underlying cause of neuropathy. It is crucial to avoid self-medication and consult your healthcare provider if you experience any symptoms of neuropathy. 

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Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. 2023 Nov 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29489221.


Sindrup SH, Bjerre U, Dejgaard A, Brøsen K, Aaes-Jørgensen T, Gram LF. The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin Pharmacol Ther. 1992 Nov;52(5):547-52. doi: 10.1038/clpt.1992.183. PMID: 1424428.


Giannopoulos S, Kosmidou M, Sarmas I, Markoula S, Pelidou SH, Lagos G, Kyritsis AP. Patient compliance with SSRIs and gabapentin in painful diabetic neuropathy. Clin J Pain. 2007 Mar-Apr;23(3):267-9. doi: 10.1097/AJP.0b013e31802fc14a. PMID: 17314587.


Rafiullah M, Siddiqui K. Pharmacological Treatment of Diabetic Peripheral Neuropathy: An Update. CNS Neurol Disord Drug Targets. 2022;21(10):884-900. doi: 10.2174/1871527320666210303111939. PMID: 33655879.

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