Does Celecoxib Interact With Trazodone? (+3 Precautions)

By Ivan Kahwa

Page last updated: 02/02/2024 | Next review date: 02/02/2026

Author bio

Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.

Mr Ivan Kahwa’s Highlights:

Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.

Professional Experience:

Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.

With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.

With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.

Education:

2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.

2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.

2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.

Publications:

▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7

▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60

▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.

https://ethnobotanyjournal.org/index.php/era/article/view/4683

▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.

https://doi.org/10.53388/TMRIM202307004

▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.

https://doi.org/10.1186/s43094-021-00296-2

▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.

https://doi.org/10.5799/jmid.951600

Published book Chapter

▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.

https://doi.org/10.1016/B978-0-323-91942-5.00012-4

Submitted manuscripts Under Review:

▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience

▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine

▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology

Submitted book chapters under review

1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.

2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press

You can view my works on the following professional sites:

Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa

Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en

ORCID: https://orcid.org/0000-0002-6440-3437

Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159

Ivan Kahwa

View More north_east

In this article, we will discuss whether Celecoxib interacts with Trazodone. We will also discuss some research studies and what to do if this interaction occurs.

Does Celecoxib interact with Trazodone?

Celecoxib and Trazodone may interact. The two may not interact chemically, but the side effects they cause can significantly harm your normal physiological systems.

The combination of Celecoxib and Trazodone carries an increased risk of gastrointestinal adverse effects; hence it should be avoided in patients who are more prone to experience stomach problems.

Celecoxib is a non-steroidal anti-inflammatory drug. It may enhance the effectiveness of Trazodone, an antidepressant, when used in combination to treat inflammation, especially in the initial stages of antidepressant treatment; however, it may also be associated with side effects (1,2).

What does research suggest?

There is limited research indicating the interaction between Trazodone and Celecoxib. One study found that taking Celecoxib along with Escitalopram and Trazodone might lead to feelings of nervousness or anxiety (3).

This could happen because Celecoxib might affect how these antidepressants work in the body or influence the brain’s serotonin activity, causing this jittery or anxious reaction (3).

Another clinical study suggested that Celecoxib works by reducing inflammation; hence it might play a role in improving depression symptoms. Patients recover faster from depression when Celecoxib is administered alongside antidepressants compared to antidepressant treatment alone (4).

The benefits or harms of this combination may not be applied to everyone, as people respond differently to medications.

What are the benefits of using Celecoxib and Trazodone together?

When Celecoxib and Trazodone are used in combination, patients may experience quick relief from their depression symptoms. This combination therapy may increase the chances of complete relief from depression when compared to patients taking Trazodone alone for their depression.

Furthermore, Celecoxib and Trazodone combination treatment could also be beneficial for managing mood-related symptoms and pain simultaneously.

However, this combination of Celecoxib and Trazodone should only be taken if prescribed by your healthcare provider to ensure the safe and effective use of this combination.

What are the risks of using Celecoxib and Trazodone together?

When NSAIDs such as Celecoxib are combined with antidepressants like Trazodone, you may have a higher risk of stomach disorders compared to those who take antidepressants and NSAIDs alone (5).

The risk of stomach bleeding may be increased with Celecoxib and Trazodone combination therapy. If you are using this combination and have a history of stomach problems, you should be aware of the side effects and watch out for them vigilantly (5).

If the doses of Celecoxib and Trazodone are not adjusted properly, several side effects may occur including:

Nausea
Vomiting
Acid reflux
Jitteriness (3)
Dry mouth
Sweating
Constipation
Bloating
Metallic taste in mouth
Flu-like symptoms (2)

Who is prone to side effects of Celecoxib and Trazodone combination?

The following individuals may be more prone to side effects when taking a combination of Celecoxib and trazodone:

Patients who are using antidepressants with NSAIDs for the first time are at a higher risk of stomach problems (2).
Patients with a history of acid reflux due to certain dietary factors (6).
Elderly patients often have underlying health conditions, like ulceration, bleeding risks and weak stomach and intestines (2).
Patients with bleeding disorders may experience an increased risk of blood thinning.
Patients with kidney problems may experience disturbances in fluid and electrolyte balance.
Individuals with a history of cardiovascular diseases are at an increased risk of heart attacks and strokes.

What are the precautions while using Celecoxib and Trazodone together?

Before using the combination therapy of Celecoxib and Trazodone, inform your doctor if you are:

Hypersensitive to Celecoxib (NSAID) or Trazodone
Taking monoamine oxidase inhibitors (MAOI) antidepressants
Using any other medication or supplements
Pregnant or plan to become pregnant
Opting for any surgery including dental surgery

In my view and the knowledge available, Celecoxib can interact with Trazodone. Celecoxib and Trazodone can have potential benefits and risks. It is crucial to consult your healthcare professional before taking these two medications together. They can evaluate your specific health situation, consider any other medications you are taking, and determine if the combination is safe and appropriate for you.