Does Celecoxib interact with Trazodone? (+3 precautions)

In this article, we will discuss whether Celecoxib interacts with Trazodone. We will also discuss some research studies and what to do if this interaction occurs.

Does Celecoxib interact with Trazodone?

Celecoxib and Trazodone may interact. The two may not interact chemically, but the side effects they cause can significantly harm your normal physiological systems.

The combination of Celecoxib and Trazodone carries an increased risk of gastrointestinal adverse effects; hence it should be avoided in patients who are more prone to experience stomach problems.

Celecoxib is a non-steroidal anti-inflammatory drug. It may enhance the effectiveness of Trazodone, an antidepressant, when used in combination to treat inflammation, especially in the initial stages of antidepressant treatment; however, it may also be associated with side effects (1,2).

What does research suggest?

There is limited research indicating the interaction between Trazodone and Celecoxib. One study found that taking Celecoxib along with Escitalopram and Trazodone might lead to feelings of nervousness or anxiety (3).

This could happen because Celecoxib might affect how these antidepressants work in the body or influence the brain’s serotonin activity, causing this jittery or anxious reaction (3).

Another clinical study suggested that Celecoxib works by reducing inflammation; hence it might play a role in improving depression symptoms. Patients recover faster from depression when Celecoxib is administered alongside antidepressants compared to antidepressant treatment alone (4).

The benefits or harms of this combination may not be applied to everyone, as people respond differently to medications.

What are the benefits of using Celecoxib and Trazodone together?

When Celecoxib and Trazodone are used in combination, patients may experience quick relief from their depression symptoms. This combination therapy may increase the chances of complete relief from depression when compared to patients taking Trazodone alone for their depression.

Furthermore, Celecoxib and Trazodone combination treatment could also be beneficial for managing mood-related symptoms and pain simultaneously. 

However, this combination of Celecoxib and Trazodone should only be taken if prescribed by your healthcare provider to ensure the safe and effective use of this combination.

What are the risks of using Celecoxib and Trazodone together?

When NSAIDs such as Celecoxib are combined with antidepressants like Trazodone, you may have a higher risk of stomach disorders compared to those who take antidepressants and NSAIDs alone (5).

The risk of stomach bleeding may be increased with Celecoxib and Trazodone combination therapy. If you are using this combination and have a history of stomach problems, you should be aware of the side effects and watch out for them vigilantly (5).

If the doses of Celecoxib and Trazodone are not adjusted properly, several side effects may occur including:

  • Nausea
  • Vomiting
  • Acid reflux
  • Jitteriness (3)
  • Dry mouth
  • Sweating
  • Constipation
  • Bloating
  • Metallic taste in mouth
  • Flu-like symptoms (2)

Who is prone to side effects of Celecoxib and Trazodone combination?

The following individuals may be more prone to side effects when taking a combination of Celecoxib and trazodone:

  • Patients who are using antidepressants with NSAIDs for the first time are at a higher risk of stomach problems (2).
  • Patients with a history of acid reflux due to certain dietary factors (6).
  • Elderly patients often have underlying health conditions, like ulceration, bleeding risks and weak stomach and intestines (2).
  • Patients with bleeding disorders may experience an increased risk of blood thinning.
  • Patients with kidney problems may experience disturbances in fluid and electrolyte balance.
  • Individuals with a history of cardiovascular diseases are at an increased risk of heart attacks and strokes.

What are the precautions while using Celecoxib and Trazodone together?

Before using the combination therapy of Celecoxib and Trazodone, inform your doctor if you are:

  • Hypersensitive to Celecoxib (NSAID) or Trazodone
  • Taking monoamine oxidase inhibitors (MAOI) antidepressants 
  • Using any other medication or supplements
  • Pregnant or plan to become pregnant
  • Opting for any surgery including dental surgery

In my view and the knowledge available, Celecoxib can interact with Trazodone. Celecoxib and Trazodone can have potential benefits and risks. It is crucial to consult your healthcare professional before taking these two medications together. They can evaluate your specific health situation, consider any other medications you are taking, and determine if the combination is safe and appropriate for you.


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