Does Carafate need to be refrigerated? (+1 tips)

In this article, we will discuss the proper storage condition of Carafate. Carafate (sucralfate) is used to treat stomach ulcers, radiation proctitis, inflammation, and gastroesophageal reflux disease (GERD).

Does Carafate need to be refrigerated?

No, Carafate does not need to be refrigerated. Carafate should be stored at room temperature (20-25°C). Carafate is available as a tablet (1000 mg), and suspension (1000 mg/10 ml). Both dosage forms do not require refrigeration according to the manufacturer’s guidelines (1).

Generally, tablets and liquids remain stable at room temperature. However, extreme heat may degrade the product, especially suspension. Always follow the storage guidelines provided by your doctor or the manufacturer to ensure Carafate’s stability and effectiveness.

Can Carafate be refrigerated during a hot day?

You may put Carafate suspension in a fridge as a precautionary measure during a very hot day, however, do not put it in the freezer. Exposure of Carafate to high temperatures may reduce its efficacy. This is especially true for suspensions (2).

Liquid present in the Carafate suspension may dry up, disrupting the normal dose of the drug. This may reduce the effectiveness and compromise the safety of Carafate. However, such conditions may not apply to Carafate tablets. 

As the excipients present in the tablets are more stable and are not affected by hot temperatures, the tablets will retain their potency even at high temperatures. The ideal storage condition for Carafate tablet and suspension is 20-25°C.

What are the proper storage guidelines for Carafate?

Carafate should be stored at conditions specified by the manufacturer or doctor. The appropriate storage conditions protect the drug from stability issues, contamination, and degradation. It also helps ensure the safe and effective delivery of Carafate to the patient (2, 3).

  • Store Carafate at room temperature (20-25°C, 68-77°F)
  • Keep the medicine away from light.
  • Do not take the tablet out of the blister before use.
  • Tightly cap the suspension bottle after use.
  • Keep Carafate away from the reach of children and animals.
  • Do not store Carafate in the bathroom. Put away in a suitable cabinet or storage area.
  • Do not flush Carafate in the toilet, or pour down in the drain unless instructed by a doctor.
  • Throw away any unused Carafate suspension and tablet after the expiry date.

What is the shelf-life of Carafate?

Shelf-life of the product refers to the period during which Carafate will retain its efficacy if stored in the correct storage condition. The shelf-life of the Carafate tablet and suspension is 2 years.

You should shake the Carafate suspension bottle before use to resuspend the drug in the liquid medium. Once you open the bottle, try to consume the suspension within one month. Keep the tablets within the blister to protect them from humidity, light, and contamination. 

How to know if Carafate has gone bad?

Examine the tablet visually, in or outside the blister. If you see any sign of sticking, cracking, or migration (irregular pink colour distribution) then it means the tablet has gone bad.

If you observe the tablets have become wet (due to moisture absorption), sticking together, or are past their expiry date, then you should not consume these tablets (4). In the case of Carafate suspension, first of all, observe the colour of the suspension.

If you see that the colour is not uniform, or there are two separate layers of suspension in the bottle, it means the suspension is no longer safe for consumption. Any significant change in taste also signifies spoilage and degradation.

As a pharmacist, I always advise my patients to keep a close eye on the visual appearance and integrity of dosage forms. Store Carafate at room temperature to maintain its shelf life. Also, you should never take expired Carafate as it tends to lose its effectiveness.

Was this helpful?

Thanks for your feedback!



Kudaravalli P, John S. Sucralfate.


Kostka MD, Frisolone J, Rudnick E. Making decisions about drug repackaging. American journal of health-system pharmacy. 1996 Mar 1;53(5):564-5.


McGraw BF, Caldwell EG. Sucralfate. Drug Intelligence & Clinical Pharmacy. 1981 Jul;15(7-8):578-80.


Rana AS, Kumar SH. Manufacturing defects of tablets-a review. Journal of Drug Delivery and Therapeutics. 2013;3(6):200-6.