Does Betamethasone dipropionate expire? 

Does Betamethasone dipropionate expire? 

Yes, Betamethasone dipropionate does expire. The topical cream usually comes with a printed shelf-life of 36-48 months. However, if stored properly, the formulation can outlive its expiry date. 

However, semi-liquid dosage forms should be discarded after the expiration date because they are not as stable as solid dosage forms when they are past the expiration date. 

What are the dangers associated with the use of expired Betamethasone dipropionate? 

Expired Betamethasone dipropionate is not toxic and it does not pose any health concern. However, the drug may lose its potency with time and it will not deliver promising results. This can lead to therapeutic failure, as you will not see a positive difference in your symptoms. 

However, some people may experience slight allergic symptoms on their site of application, like redness of the skin, itching, burning sensation, blisters, etc. It is quite rare but is still a possibility. It’s best to avoid using expired medications (1). 

What to do if you have used expired Betamethasone dipropionate? 

If you have used expired Betamethasone dipropionate cream, you don’t have to worry about it. You will most likely not experience any unusual side effects. 

In fact, if Betamethasone dipropionate has recently expired, you will still be able to achieve the therapeutic response you’re expecting. However, if you notice any allergic symptoms, reach out to your healthcare provider. 

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U.S. Food and Drug Administration. Don’t Be Tempted to Use Expired Medicines [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2021 [cited 2022 Oct 21]. Available from: