Does Amoxicillin increase blood pressure? 

Does Amoxicillin increase blood pressure? 

No, Amoxicillin does not increase blood pressure or heart rate. In fact, this antibiotic is considered safe to be used by people who suffer from chronic hypertension and it does not interact with prescription antihypertensives as well.

However, people who are allergic to Amoxicillin can experience a sudden rise in blood pressure, heart rate, breathing rate, etc. Then again, allergies are quite rare and it’s an entirely different condition. 

As far as common side effects of Amoxicillin are concerned, high blood pressure is not listed as one of them. This antibiotic can be taken by hypertensive individuals and it can be safely taken along with medications that manage high blood pressure

What side effects are common with Amoxicillin?

Amoxicillin, although it does not affect your blood pressure, is associated with some side effects – ranging from mild to severe. (1,2)

Common side effects of Amoxicillin include:

  • Upset stomach
  • Diarrhoea
  • Nausea
  • Vomiting
  • Abdominal pain
  • Skin rash
  • Headache
  • Vaginal itching or discharge (in women)

Rare side effects of Amoxicillin, although less common, may include:

  • Allergic reactions, such as hives, itching, or swelling
  • Severe skin reactions, including Stevens-Johnson syndrome or toxic epidermal necrolysis
  • Severe diarrhoea (pseudomembranous colitis)
  • Blood disorders, such as low white blood cell count or low platelet count
  • Liver problems, such as hepatitis or jaundice
  • Kidney problems, such as interstitial nephritis

It’s important to note that while these side effects are possible, they do not occur in every individual taking Amoxicillin. Gastrointestinal side effects can be prevented, to some extent, by taking Amoxicillin with food 

If you experience any concerning or persistent side effects, it is recommended to seek medical attention and inform your healthcare provider.

Factors that can affect blood pressure while taking Amoxicillin

While Amoxicillin itself does not directly increase blood pressure, there are certain factors that can affect blood pressure while taking this medication. These factors include: (3)

  • Underlying health conditions: If you have pre-existing conditions such as high blood pressure, heart disease, or kidney disease, these can influence your blood pressure levels.
  • Individual response: Each person may react differently to medications, and some individuals may experience changes in blood pressure while taking Amoxicillin.
  • Other medications: If you are taking other medications alongside Amoxicillin, they might have an impact on your blood pressure. For example, certain medications like decongestants or non-steroidal anti-inflammatory drugs (NSAIDs) can raise blood pressure.
  • Lifestyle factors: Your lifestyle choices, such as diet, exercise, stress levels, and alcohol consumption, can affect your blood pressure. These factors may interact with the effects of Amoxicillin.

What to do if you’re struggling with high blood pressure while taking Amoxicillin? 

If you’re experiencing difficulties with high blood pressure while taking Amoxicillin, it’s important to take some steps to manage it. Firstly, consult with your healthcare provider about your concerns.  They can evaluate your situation and guide you accordingly. 

They may adjust your dosage of Amoxicillin or consider alternative medications if necessary. Additionally, it’s crucial to continue taking any prescribed medications for managing high blood pressure as directed. 

Maintaining a healthy lifestyle can also be beneficial. This includes following a balanced diet low in sodium, engaging in regular physical activity, managing stress levels, and avoiding tobacco and excessive alcohol consumption. 

Monitoring your blood pressure regularly at home can help you keep track of any changes and report them to your healthcare provider. Remember, open communication with your doctor is key to effectively managing your health

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Evans J, Hanoodi M, Wittler M. Amoxicillin Clavulanate. 2022 Dec 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30844191.


Gillies M, Ranakusuma A, Hoffmann T, Thorning S, McGuire T, Glasziou P, Del Mar C. Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication. CMAJ. 2015 Jan 6;187(1):E21-E31. doi: 10.1503/cmaj.140848. Epub 2014 Nov 17. PMID: 25404399; PMCID: PMC4284189.


Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cífková R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A, Whelton PK. Hypertension. Nat Rev Dis Primers. 2018 Mar 22;4:18014. doi: 10.1038/nrdp.2018.14. PMID: 29565029; PMCID: PMC6477925.