Can Zoloft cause a lump-in-throat feeling? 

In this brief article, we will address the question: Can Zoloft cause a lump-in-throat feeling? We will explore the reasons behind these symptoms, discuss potential treatments, and shed light on why this symptom is often mistaken as a side effect of Zoloft.

Can Zoloft cause a lump-in-throat feeling?

No, the lump-in-throat sensation is not a typical side effect of Zoloft (1). However, many individuals have reported this symptom while taking Zoloft.

Most people describe it as something stuck in their throat, like a ball. You should monitor your side effects and report them to your healthcare provider, especially if you’re new to Zoloft or antidepressants in general. 

Some antidepressants can help lump-in-throat feelings or globus sensations. Zoloft may also help globus sensations, but there is not enough research on this topic.

What are the possible causes of lump-in-the-throat feelings? 

Zoloft can cause a lump-in-throat feeling because of one of the two major side effects it causes:

The possible causes of a lump-in-the-throat are (2):

  • Gastroesophageal reflux disease 
  • Pharyngeal cancer 
  • Esophageal motor disorders
  • Psychological factors and stress

What to do if you have a lump-in-the-throat feeling when taking Zoloft?

If you experience a lump-in-the-throat feeling while taking Zoloft, you should consult a doctor to determine the cause of this symptom, as it can have various potential causes (2). Your doctor will then assess whether the symptom is associated with the use of Zoloft.

Zoloft may cause a lump-in-throat feeling by causing severe acid reflux, that could damage the throat. This can also lead to swallowing difficulty in some individuals.

Zoloft-induced acid reflux should be managed, as persistent acid attacks on the lining of your stomach can make you susceptible to conditions like gastritis. So, it is important to discuss this side effect with your healthcare provider.

What are the possible treatments for lump-in-the-throat feelings?

There are several potential treatments available to alleviate the sensation of a lump in the throat. 

These may include anti-reflux therapy to address any acid reflux issues, therapies aimed at improving gastrointestinal movement, and treatments specifically designed to reduce the perception of a lump in the throat (2).

Additionally, other treatment options such as Cognitive-behavioral therapy and antidepressant medications can be considered as second and third-line therapies. 

These approaches are beneficial because stress and psychological factors can contribute to the sensation of a lump in the throat, and these treatments specifically address those underlying causes (2,3).

Why is Zoloft mistaken for causing a lump-in-the-throat feeling?

Zoloft can be mistaken for causing lump-in-the-throat feelings because one of the causes of this condition is anxiety and stress. So, patients who use antidepressants such as Zoloft may end up mistaking the symptoms for the adverse effects of the medication (2,3).

You may feel like you have a lump in your throat if you have a throat infection and swelling associated with the infection. If that’s the case, your doctor may prescribe antibiotics to help with the infection, and Zoloft can be taken with antibiotics like Amoxicillin.


This short article clarified doubts regarding the following question: Can Zoloft cause a lump-in-throat feeling? The possible causes for this symptom were described, as well as, How Zoloft can be used to treat the symptom.

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MedlinePlus. Sertraline: MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2023 Jun 17]. Available from:


Manabe N, Tsutsui H, Kusunoki H, Hata J, Haruma K. Pathophysiology and treatment of patients with globus sensation – From the viewpoint of esophageal motility dysfunction-. J Smooth Muscle Res. 2014;50(1):66–77. Available from:


Lee BE, Kim GH. Globus pharyngeus: A review of its etiology, diagnosis and treatment. World J Gastroenterol. 2012;18(20):2462–71. Available from:

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