Can you take magnesium while taking Sertraline?

In this article, we will discuss the concomitant use of magnesium and Sertraline. We will also talk about the basic link between magnesium consumption and depression, and how magnesium can actually help some people with their affective mood disorder.

Can you take magnesium while taking Sertraline?

Yes, you can take Magnesium while taking Sertraline. There is no known interaction between magnesium and Sertraline, and they may even work together to manage symptoms associated with depression (1,2). 

However, people are different and can respond differently to such combinations. Magnesium is considered a relatively safe element, and in most cases, it doesn’t interfere with how Sertraline works or significantly affects serotonin levels. 

However, individual responses to medications can vary, and there could be a possibility of unexpected interactions. It’s best to discuss the use and appropriate dosage of Magnesium supplements with your doctor while you’re being treated with Sertraline.

What does research suggest?

There is limited research on the possible interactions between magnesium and Sertraline. However, studies do show a close link between magnesium and depression. 

Magnesium has a history of helping with depression, dating back to 1921. It’s linked to improved mental health and mood because it’s needed to convert tryptophan into serotonin, an important neurotransmitter for our well-being (3). 

Some studies suggest that magnesium supplements might prevent depression and support other therapies (3). Additionally, medications like sertraline and amitriptyline can increase magnesium levels in the body, possibly contributing to their effectiveness. 

Magnesium also acts as a natural antidepressant by blocking NMDA receptors, similar to the way ketamine does, offering potential benefits for treatment-resistant depression (3).

Research also suggests that a diet rich in magnesium may be linked to lower depression symptoms, although we can’t rule out the possibility that depression affects magnesium intake (4). 

The relationship between magnesium levels in the blood and cerebrospinal fluid and depression is unclear. While magnesium shows promise as a depression treatment, the existing data is limited and somewhat inconsistent (4). 

It’s possible that imbalances in magnesium metabolism could be related to depression. Taking magnesium supplements by mouth might help prevent depression and could be used alongside other treatments (4). 

However, more studies, especially trials and long-term research, are needed to fully understand the benefits of magnesium for depression. 

In general, magnesium is a vital element and can help prevent conditions like depression, headaches, and constipation. It is also responsible for various physiological functions. 

What are the dosage recommendations for magnesium?

The general recommendation for magnesium intake is around 350 mg per day, which is considered safe for most people and doesn’t typically cause side effects (5). 

Some case histories have shown rapid recovery from major depression with doses ranging from 125 mg to 300 mg of magnesium (as glycinate and taurinate) taken with meals and at bedtime, with improvements in less than 7 days (6). 

However, it’s crucial to emphasise that the exact dose of magnesium, especially if you’re taking Sertraline or any other antidepressant, should be determined by a healthcare provider who is familiar with your medical history and specific needs. 

What to do if taking magnesium with Sertraline is not working out for you?

If you’re taking magnesium along with Sertraline and you don’t feel so well, please reach out to your doctor. While this combination is generally considered safe, everyone’s body can react differently to medications. 

So, if you’re experiencing any issues, it might not necessarily be because of this combination. Your doctor will be able to assess your situation and help figure out the best steps to ensure your treatment is safe and effective for you. 

It’s always wise to consult with your healthcare provider for proper guidance.


In this article, we have discussed the concomitant use of magnesium and Sertraline. We have also discussed how magnesium is linked to depression and can help you with your symptoms.

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Derom ML, Sayón-Orea C, Martínez-Ortega JM, Martínez-González MA. Magnesium and depression: a systematic review. Nutr Neurosci. 2013 Sep;16(5):191-206. doi: 10.1179/1476830512Y.0000000044. Epub 2012 Dec 6. PMID: 23321048.


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