Can you take Luvox and Seroquel together? (+3 side effects)
By
Dr Drielli Vital-Fujii (PhD)
Author bio
Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics.
Dr Drielli Vital-Fujii’s Highlights:
- Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.
- PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)
- Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.
- Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil
Professional Experience:
2012 – 2018 Project manager at University of São Paulo – Pharmacy Department
Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.
2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.
She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).
2018 – 2019 Faculdades Oswaldo Cruz
Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.
2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department
She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.
2023-2023 UniPiaget – University Center.
Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.
Education:
2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo
2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo
2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo
2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes
The leading publications of Dr Drielli Vital-Fujii are:
Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.
Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.
Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.
Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.
Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.
Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.
Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.
Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.
Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.
You can view some of Dr Drielli’s work below and links to her professional profile.
Orcid: https://orcid.org/0000-0001-9270-0466
Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii
Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000
Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR
Linkedin: linkedin.com/in/driellivital
Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital
CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists
In this article, we are going to discuss whether or not Luvox and Seroquel can be taken together, the potential side effects of combining Luvox and Seroquel together, safe alternatives to be used with Luvox if Seroquel causes side effects, and important precautions to be considered while taking Luvox and Seroquel together.
Can you take Luvox and Seroquel together?
Luvox and Seroquel can be taken together. However, taking both medications together may result in drug interactions and adverse effects that must be carefully monitored.
Luvox is the brand name of the medication fluvoxamine, an antidepressant belonging to the class of drugs known as SSRIs (Selective Serotonin Reuptake Inhibitors). Luvox is FDA-approved for the treatment of OCD (Obsessive Compulsive Disorder) and SAD (Social Anxiety Disorder). It functions by enhancing the levels of a natural neurotransmitter known as serotonin in the brain. (1)
Seroquel is the brand name of the medication quetiapine. An atypical antipsychotic medication that is used mainly in the treatment of psychosis (Schizophrenia), MDD (Major Depressive Disorder), and bipolar disorder. (2)
When used in tandem, Luvox and Seroquel have an impact on the neurotransmitter levels in the brain and may alter how the brain works. It’s crucial to report any unexpected symptoms or side effects to your healthcare provider while taking Luvox and Seroquel together.
How do Luvox and Seroquel interact together when combined?
Combining Luvox and Seroquel may result in specific drug interactions and side effects as Luvox and Seroquel influence the brain in various ways.
Evidence suggests that Luvox may improve Seroquel absorption. This happens as a result of Luvox’s inhibition of the CYP 3A4 enzyme, which is necessary for Seroquel metabolism. Luvox may increase the amount of Seroquel in the bloodstream by blocking this enzyme. (3)
It is crucial to consult your healthcare provider about any possible interactions if you take Luvox and Seroquel together.
When can you take Luvox and Seroquel together?
According to a research study, it was found that you can combine both Luvox and Seroquel for certain mental health issues such as Schizophrenia, OCD (Obsessive Compulsive Disorder), and MDD (Major Depressive Disorder).
It has been demonstrated that quetiapine (Seroquel) and fluvoxamine (Luvox) together stimulate the dopamine neurotransmitter in the thalamus and prefrontal cortex of the brain in a synergistic manner. (4)
Your healthcare provider may recommend combining both Luvox and Seroquel if they believe that there are more benefits to taking them together than risks. However, it’s crucial to pay attention closely to your healthcare provider’s instructions and to report any side effects right away.
What are the side effects of combining Luvox and Seroquel together?
There are several side effects and interactions that may occur when combining Luvox and Seroquel together such as: (1), (5)
- Drowsiness and dizziness.
- Weight gain (especially with Seroquel) and increased appetite.
- Constipation.
- Xerostomia (dry mouth).
Other adverse effects include:
- Increased blood glucose and cholesterol levels.
- Motor and cognitive impairment.
- Involuntary motions of the mouth, face, or other body parts.
- Arrhythmia and seizures.
- Dysphagia (difficulty swallowing).
If you experience these side effects or any other symptoms while taking Luvox and Seroquel together, contact your healthcare provider immediately. They will properly assess your situation and the cause of side effects and take the proper action accordingly.
Which antipsychotics are safe to take with Luvox?
There are some antipsychotics that are generally considered safe to be combined with Luvox in treating schizophrenia such as:
Clozapine: According to research, clozapine was shown effective, well-tolerated, and safe in treating schizophrenia along with Luvox. (6)
Risperidone, paliperidone, and olanzapine: These antipsychotics can be used instead of Seroquel in combination with Luvox to treat schizophrenia. (7)
However, these antipsychotics may increase the risk of side effects while combining them with Luvox. Therefore, it is essential to carefully monitor any side effects or interactions that may arise while combining them together.
Important precautions while taking Luvox with Seroquel
The following crucial safety measures and precautions should be considered when combining Luvox and Seroquel: (8), (9)
- Keep a careful eye and monitor your blood pressure because both drugs have the potential to lower your BP.
- While taking Luvox with Seroquel, be mindful of any possible sedative effects and refrain from driving until you see how both drugs affect you.
- Notify your physician of any changes in your emotions, thoughts, behavior, or any other side effects that may arise from using both medications together.
- Your physician should be informed of any additional medications, vitamins, or supplements that you take to avoid further drug interactions.
- You should never abruptly discontinue the medications without the consultation of your physician. They will reduce your dose gradually to avoid withdrawal symptoms.
- Steer off alcohol while taking both medications together, as it may aggravate side effects.
Conclusion
Based on my knowledge and experience, you can take Luvox with Seroquel. However, combining these medications together can increase the risk of side effects. Follow your healthcare provider’s guidelines and be aware of any arising side effects or interactions that may occur while using Luvox and Seroquel together.
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References
1.-
Fluvoxamine: MedlinePlus Drug Information [Internet]. medlineplus.gov. Available from: https://medlineplus.gov/druginfo/meds/a695004.html#:~:text=Fluvoxamine%20is%20used%20to%20treat,that%20interferes%20with%20normal%20life).
2.-
Quetiapine: MedlinePlus Drug Information [Internet]. medlineplus.gov. 2020. Available from: https://medlineplus.gov/druginfo/meds/a698019.html
3.-
Daly EJ, Trivedi MH. A review of quetiapine in combination with antidepressant therapy in patients with depression. Neuropsychiatric Disease and Treatment [Internet]. 2007 Dec 1;3(6):855–67. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656328/
4.-
Denys D, Klompmakers AA, Westenberg HGM. Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine. Psychopharmacology [Internet]. 2004 Nov 1 [cited 2023 Nov 18];176(2):195–203. Available from: https://pubmed.ncbi.nlm.nih.gov/15138756/
5.-
NHS. Side effects of quetiapine [Internet]. nhs.uk. 2022. Available from: https://www.nhs.uk/medicines/quetiapine/side-effects-of-quetiapine/
6.-
Silver H. Fluvoxamine as an adjunctive agent in schizophrenia. CNS drug reviews [Internet]. 2001 [cited 2022 Jan 15];7(3):283–304. Available from: https://pubmed.ncbi.nlm.nih.gov/11607044/
7.-
Silver H, Barash I, Aharon N, Kaplan A, Poyurovsky M. Fluvoxamine augmentation of antipsychotics improves negative symptoms in psychotic chronic schizophrenic patients: a placebo-controlled study. International Clinical Psychopharmacology. 2000 Sep;15(5):257–61. Available from: https://pubmed.ncbi.nlm.nih.gov/10993127/
8.-
Fluvoxamine (Oral Route) Precautions – Mayo Clinic [Internet]. www.mayoclinic.org. [cited 2023 Nov 15]. Available from: https://www.mayoclinic.org/drugs-supplements/fluvoxamine-oral-route/precautions/drg-20066874#:~:text=Check%20with%20your%20doctor%20right
9.-
Quetiapine (Oral Route) Precautions – Mayo Clinic [Internet]. www.mayoclinic.org. [cited 2023 Nov 15]. Available from: https://www.mayoclinic.org/drugs-supplements/quetiapine-oral-route/precautions/drg-20066912?p=1#:~:text=Do%20not%20take%20more%20of
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