Can you take Cymbalta and Wellbutrin together? (+3 benefits)

In this article, we will explore the combination of Cymbalta and Wellbutrin. We will also discuss the research studies suggesting the reported benefits and side effects of taking these medications together. 

Can you take Cymbalta and Wellbutrin together?

Yes, you can take Cymbalta and Wellbutrin together. According to research, combining Cymbalta and Wellbutrin in low doses has shown potential for enhancing the effectiveness of these medications in treating various mental disorders, however, the combination of drugs may also cause side effects in some individuals.

Cymbalta belongs to the class of serotonin and norepinephrine reuptake inhibitors. It helps in the regulation of mood in individuals with underlying mental disorders such as anxiety and depression. Additionally, Cymbalta is also effective in the management of fibromyalgia and chronic pain (1).

On the other hand, Wellbutrin belongs to the class of drugs known as atypical antidepressants and works by affecting certain neurotransmitters in the brain, particularly norepinephrine, and dopamine. It is commonly used to manage the symptoms associated with depression and anxiety (2). 

What does research suggest?

In a research study, the use of Cymbalta and Wellbutrin for managing depression was analyzed for one month. The evaluation after this period demonstrated the effectiveness of this combination in alleviating depressive symptoms. However, some patients experienced mild to moderate side effects, including nausea, dizziness, agitation, tiredness, and headaches (3).

 A research study demonstrated that the combination of Cymbalta and Wellbutrin induced delirium in a patient undergoing this treatment for depression. Delirium symptoms emerged approximately one week after adding Wellbutrin to the existing Cymbalta regimen. The symptoms gradually subsided within a few days after discontinuing Wellbutrin (4).

The combination of Cymbalta and Wellbutrin led to elevated hydroxybupropion levels by inhibiting CYP450 enzymes responsible for the metabolism of Wellbutrin. The increased levels of this metabolite resulted in elevated dopamine levels in the brain, contributing to the development of delirium (4).

What are the benefits of combining Cymbalta and Wellbutrin? 

The combination of Cymbalta and Wellbutrin may offer benefits to certain individuals who suffer from depression. A healthcare professional should make the decision to use this combination after considering the individual’s specific needs and medical history.

The combination of these medications may lead to a more comprehensive approach to managing depression due to their different mechanisms of action. The combination may help manage a range of symptoms associated with mental disorders.

In some cases, using a combination of medications at lower doses may help minimize side effects compared to using higher doses of a single medication.

It’s important to note that individual responses to medications vary, and potential benefits should be weighed against potential risks. Regular monitoring and communication with a healthcare provider are essential to ensure the optimal treatment plan and address any emerging concerns.

What are the side effects of combining Wellbutrin and Cymbalta?

The concurrent use of Cymbalta and Wellbutrin may lead to some adverse effects such as (3),

  • vomiting
  • delirium
  • hallucinations
  • fatigue
  • agitation
  • aggression
  • confusion
  • dizziness
  • jitteriness
  • sleep disturbances
  • weight gain
  • hyperhidrosis 
  • drowsiness

Consult your doctor if you experience any unwanted side effects associated with the use of this combination. 

Considerations before taking Cymbalta and Wellbutrin together

Always consult your healthcare professional before using these medications together. The combination of these antidepressant medications should only be taken under the guidance of a qualified healthcare professional.

Inform your healthcare provider about all medications you are taking, including non-prescription drugs as certain medications may interact with Cymbalta or Wellbutrin.

These interactions could impact the therapeutic benefits of the medications or elevate the risk of adverse effects. Open communication with your healthcare provider is essential for ensuring the safe and optimal use of these medications.

Be sure to provide a thorough history of your medical conditions, including any history of seizures, liver problems, or other mental conditions. It is important to note that Wellbutrin has a lower seizure threshold, and this risk may increase when combined with certain medications.

You should be vigilant for any side effects and report them promptly to your healthcare provider. The side effects may differ from those experienced with each medication alone, so it is important to keep track of how you are feeling.

Remember, the decision to combine medications should be made collaboratively with your healthcare provider based on a comprehensive evaluation of your health. Open communication about your experiences and any concerns is vital for effective treatment.

In my opinion, the combination of Cymbalta and Wellbutrin is effective in the management of treatment-resistant mental disorders such as depression. However, this combination should only be used only the guidance and supervision of a healthcare professional to ensure the safety and efficacy of treatment.

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Dhaliwal JS, Spurling BC, Molla M. Duloxetine. 2023 May 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 31747213. a


Khan SR, Berendt RT, Ellison CD, Ciavarella AB, Asafu-Adjaye E, Khan MA, Faustino PJ. Bupropion Hydrochloride. Profiles Drug Subst Excip Relat Methodol. 2016;41:1-30. doi: 10.1016/bs.podrm.2015.12.001. Epub 2016 Feb 17. PMID: 26940167.


Papakostas GI, Worthington JJ 3rd, Iosifescu DV, Kinrys G, Burns AM, Fisher LB, Homberger CH, Mischoulon D, Fava M. The combination of duloxetine and bupropion for treatment-resistant major depressive disorder. Depress Anxiety. 2006;23(3):178-81. doi: 10.1002/da.20181. PMID: 16528701.


Ma SP, Tsai CJ, Chang CC, Hsu WY. Delirium associated with concomitant use of duloxetine and bupropion in an elderly patient. Psychogeriatrics. 2017 Mar;17(2):130-132. doi: 10.1111/psyg.12202. Epub 2016 Apr 5. PMID: 27046219.

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