Can you switch from Ativan to Klonopin? (+5 Reasons)

In this article, we will discuss whether you can switch from Ativan to Klonopin. We will also explore the reasons for transitioning from Ativan to Klonopin, as well as the safe ways for transitioning between benzodiazepines. Additionally, we will address the steps to take if Klonopin causes side effects after the switch.

Can you switch from Ativan to Klonopin?

Yes, you can switch from Ativan to Klonopin, but this transition should be conducted under the guidance of your healthcare professional. Abrupt discontinuation of Ativan should be avoided to prevent withdrawal effects. Both Ativan and Klonopin are benzodiazepine medications that affect the central nervous system.

Ativan is commonly used for immediate relief of acute anxiety symptoms or during panic attacks, given its quicker onset. However, this may necessitate more frequent dosing throughout the day compared to longer-acting benzodiazepines like Klonopin (1).

On the other hand, Klonopin has a longer half-life and a more prolonged duration of action, that is often prescribed for conditions requiring sustained effects, such as certain types of seizures or chronic anxiety disorders (2).

What does research suggest?

According to research findings, the transition between benzodiazepines should involve a gradual tapering of the initial medication’s dose while introducing the second medication at a lower dose to mitigate withdrawal effects (3).

In a specific research study focusing on a patient undergoing treatment for obsessive-compulsive disorder (OCD) with Ativan, a switch to Klonopin was initiated due to the occurrence of panic attacks associated with Ativan.

Following a carefully designed protocol, this patient underwent a successful transition to Klonopin, resulting in improvements in obsessive-compulsive disorder symptoms and a notable reduction in the frequency of panic attacks.

The study indicated that, at equal doses, Klonopin demonstrated greater efficacy than Ativan in alleviating the obsessive thoughts experienced by the patient (4).

What is the best way to switch from Ativan to Klonopin? 

If you find that Ativan is either ineffective or causing undesirable side effects, prompting consideration for a switch, it is essential to communicate these concerns to your healthcare provider. Based on their assessment, they may suggest switching to Klonopin, by following a gradual tapering plan to reduce Ativan dosage.

Simultaneously, a low dose of Klonopin will be incorporated into your treatment plan. An adjustment period may follow, during which both medications are utilized to ensure a seamless transition and monitor for adverse effects.

Your healthcare provider will closely monitor your response, making adjustments as needed, and scheduling regular follow-up appointments to assess progress.

It is imperative not to alter your medication regimen without consulting your healthcare provider to ensure a safe and effective transition while minimizing withdrawal risks associated with Ativan.

What reasons can lead to Ativan withdrawal? 

While the decision to switch from Ativan to Klonopin should be made in consultation with a healthcare professional, there are various reasons why such a transition might be considered. 

Individual response  Different individuals respond differently to medications. If Ativan is not well-tolerated or is less effective for a specific person, switching to Klonopin might be an option.
Ineffectiveness  If Ativan is not effectively managing anxiety or related symptoms, a switch to Klonopin may be explored as it might offer a different therapeutic response. 
Side effects  If Ativan is causing intolerable side effects, a transition to Klonopin could be considered to see if the alternative medication is better tolerated.
Longer duration of action Klonopin has a longer half-life compared to Ativan, making it suitable for individuals who require a more sustained anti-anxiety effect. 
Seizure disorders  Klonopin is commonly used to treat certain types of seizures, and if an individual develops seizures or has an existing seizure disorder, a switch from Ativan may be considered. 

What to do if Klonopin causes side effects? 

If your healthcare provider has advised transitioning from Ativan to Klonopin and you subsequently experience side effects from Klonopin, it is imperative to promptly report them to your healthcare provider.

While the side effects of Klonopin are generally mild and transient, individual responses may vary, and serious concerns may arise. Tolerance, dependence, and withdrawal issues become crucial considerations with prolonged use of Klonopin, and healthcare providers often manage the medication’s duration and dosage carefully.

The decision to use Klonopin and the ongoing monitoring of its effects should be a collaborative effort between the patient and their healthcare provider.

In my experience

In my experience within clinical settings, healthcare providers occasionally switch patients from one benzodiazepine to another based on individual responses and side effect profiles. However, it is crucial to emphasize that attempting to switch from Ativan to Klonopin without the explicit approval of your healthcare provider is not advisable.

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Ghiasi N, Bhansali RK, Marwaha R. Lorazepam. [Updated 2023 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Basit H, Kahwaji CI. Clonazepam. 2023 May 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32310470.


Kubová K, Franc A, Vysloužil J, Šaloun J, Vetchý D. New approach for detoxification of patients dependent on benzodiazepines and Z-drugs for reduction of psychogenic complications. Ceska Slov Farm. 2019 Summer;68(4):139-147. English. PMID: 31822106.


Bodkin JA, White K. Clonazepam in the treatment of obsessive compulsive disorder associated with panic disorder in one patient. J Clin Psychiatry. 1989 Jul;50(7):265-6. PMID: 2738031.