Can you split Vyvanse in half? (3 Risks)

Can you split Vyvanse in half?

No, Vyvanse (Lisdexamfetamine) should not be split or crushed. It is an extended-release medication designed to release the active ingredient slowly over time. Breaking or crushing the capsule can alter how the drug is released and may result in an incorrect dose or loss of effectiveness. It is essential to take Vyvanse as your healthcare provider prescribes.

Vyvanse is a medication approved for treating attention deficit hyperactivity disorder (ADHD) and binge eating disorder (BED). Cutting the drug can result in drug dumping, as the extended-release mechanism will be disrupted. And as the medicine is used for severe disorders like ADHD and BED, disruption in the regular dosing can prove to be harmful to the patient. (1)

What are the risks associated with splitting Vyvanse in half?

Here are some general risks associated with splitting Vyvanse in half:

  • Inconsistent Dosage: Splitting Vyvanse capsules can result in an uneven medication division. This may lead to variations in the amount of the active ingredient in each half, resulting in unpredictable effects and potentially inadequate symptom control.
  • Disruption of Extended-Release Mechanism: Vyvanse is designed as an extended-release medication formulated to release the active ingredient gradually. Splitting the capsule can disrupt this mechanism, leading to an immediate release of the drug. This sudden surge in the dosage can increase the risk of side effects, such as elevated heart rate or blood pressure.
  • Moisture and Stability Issues: When a Vyvanse capsule is split, both halves are exposed to air and moisture. Moisture can degrade the medication and affect its stability, potentially reducing its potency or altering its chemical composition. This can compromise its effectiveness and safety.

Splitting the tablet in half can also cause potential side effects like Insomnia, Nausea, Headaches etc. It is essential to follow the prescribed instructions for Vyvanse and consult a healthcare professional if there are concerns about the dosage or treatment regimen.

What are the alternatives to splitting Vyvanse in half?

Vyvanse should never be split in half. However, if you need a lower dosage or face difficulty swallowing the capsules, it’s essential to consult a healthcare professional for alternative options. They may consider the following alternatives:

  • Lower-Dose Prescriptions: Healthcare professionals can prescribe lower-dose formulations of Vyvanse that are more appropriate for the desired dosage. This ensures consistent dosing and avoids the risks associated with splitting the capsules.
  • Other Medications: Depending on the individual’s needs and medical history, healthcare professionals may consider alternative medications with lower dosages or different formulations. These may include other stimulant medications, such as Methylphenidate-based drugs or non-stimulant options like Atomoxetine.
  • Compounded Medications: In some instances, a compounding pharmacy may be able to prepare customized doses of lisdexamfetamine. This can provide a more precise dosage tailored to the individual’s needs while maintaining the integrity of the extended-release mechanism.

It’s important to remember that any changes to the prescribed dosage or treatment plan should be done under the supervision and guidance of a healthcare professional.

Was this helpful?

Thanks for your feedback!



Lisdexamfetamine (National Library of Medicine, NIH)