Can you refrigerate Barium Sulfate suspension? (7 Useful Tips)
By
Dr Natalia Marceli Stephanes (PhD)
Author bio
Dr Natália Marcéli Stephanes PhD is a Pharmacist with expertise in Drugs Administration and Toxicity; Discovery of New Drugs; Cancer Treatment; Biochemical Analyzes and Hematological Analyzes. She writes and reviews content on these topics.
Dr Natália Marcéli Stephanes’ Highlights:
- Pharmacist at the Department of Health of Santa Catarina State, Brazil
- PhD with a focus on oncology treatment
- Years of experience in commercial pharmacy
- Bachelor, Master and PhD degrees in Pharmacy at the Federal University of Santa Catarina
Professional Experience:
From her undergraduate studies to her Master’s and Doctorate degrees in Pharmacy, Dr Natália Marcéli Stephanes has participated in numerous scientific studies in the field of oncology and onco-hematology at the University Hospital of the Federal University of Santa Catarina, Brazil. Her research has focused on understanding the molecular and biochemical bases of malignant neoplasms and investigating safer and more effective therapeutic alternatives.
Dr Natália Marcéli Stephanes has also served as an assistant professor of haematology for undergraduate students at the Federal University of Santa Catarina. Additionally, she held the position of professor of Hospital Pharmacy at the Qualificar Technical School in Brazil, where she developed instructional materials for use in the Pharmacy Postgraduate Program at the Leonardo Da Vinci University Center.
In addition to her academic experiences, Dr Natália Marcéli Stephanes possesses a strong expertise in commercial pharmacy, with in-depth knowledge of medications, their routes of administration, desired effects, adverse effects, and toxicity.
Currently, Dr Natália Marcéli Stephanes works as a Pharmacist at the Health Department of Santa Catarina State, where her role entails providing pharmaceutical scientific consulting services to judges.
Education:
- 2016 Bachelor in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2018 Master in Pharmacy at the Federal University of Santa Catarina, Brazil
- 2023 PhD in Pharmacy at the Federal University of Santa Catarina, Brazil
The main publications of Dr Natália Marcéli Stephanes are:
Falchetti M ; Delgobo M, Zancanaro H, Almeida K, Das Neves RN, Dos Santos B, Stefanes NM, et al. Bishop Omics-based identification of an NRF2-related auranofin resistance signature in cancer: Insights into drug repurposing. Comput. Biol. Med [Internet]. 2023; 152:106347.
Feuser PM, Matos dos Santos PC, Cordeiro AP, Stefanes NM, Walter LO, Maioral MF, Santos-Silva MC, et al. Antineoplastic activity of free 4-nitrochalcone and encapsulated in poly(thioether-ester) nanoparticles obtained by thiol-ene polymerization in two human leukemia cell lines (Jurkat and K562). J Drug Deliv Sci Technol [Internet]. 2022; 67:102924.
Jacques AV, Stefanes NM, Walter LO, Perondi DM, Efe FL, Souza LFS, Sens L, et al. Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines. Bioorg. Chem [Internet]. 2021; 116:105315.
Duarte BF, Vieira DSC, Lisboa ML, Stefanes NM, Grando LJ, Santos-Silva MC. Características clínico-epidemiológicas de pacientes portadores de carcinoma de células escamosas de boca. Arquivos Catarinenses de Medicina. 2021; 50(2): 232–245.
Machado V, Jacques AV, Stefanes NM, Santos-Silva MC, Biavatti MW. Anti-leukemic activity of semisynthetic derivatives of Lupeol. Nat. Prod. Res. 2021; 35(22):4494-4501.
Bigolin A, Maioral MF, Stefanes NM, Mascarello A, Chiaradia-Delatorre LD, Nunes RJ, Yunes RA, et al. A novel sulfonamide derivative as a strong and selective apoptotic agent against hematological malignancies. Chem. Pap. 2020; 74:2965–2976.
Bigolin A, Maioral MF, Stefanes NM, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines. Anticancer Drugs. 2020; 31(7):709-717.
Maioral MF, Stefanes NM, Neufeldt PD, Chiaradia-Delatorre LD, Nunes RJ, Santos-Silva MC. Aldehyde biphenyl chalcones induce immunogenic apoptotic-like cell death and are promising new safe compounds against a wide range of hematologic cancers. Future Med. Chem. 2020; 12(8):673–688.
Perondi DM, Jacques AV, Stefanes NM, Maioral MF, Sens L, Pacheco LA, Cury NM, et al. A novel thiosemicarbazone as a promising effective and selective compound for acute leukemia. Anticancer Drugs. 2019; 30(8):p 828-837.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Argenta DF, Dotto MER, Santos-Silva MC, et al. PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment. Eur. Polym. J. 2019; 119:335-343.
Rengifo AFC, Stefanes NM, Toigo J, Mendes C, Santos-Silva MC, Nunes RJ, Parize AL, et al. A new and efficient carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanocarrier for a pyrazoline with antileukemic activity. Mater. Sci. Eng. C [Internet]. 2019; 105:110051.
Maioral MF, Stefanes NM, Bigolin A, Zatelli GA, Philippus AC, Falkenberg MB, Santos-Silva MC. Miconidine acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells. Invest. New Drugs. 2019; 37:912–922.
Srefanes NM, Toigo J, Maioral MF, Jacques AV, Chiaradia-Delatorre LD, Perondi DM, Ribeiro AAB, et al. Synthesis of novel pyrazoline derivatives and the evaluation of death mechanisms involved in their antileukemic activity. Bioorg. Med. Chem. 2019; 27(2):375-382.
Maioral MF, Bodack CN, Stefanes NM, Bigolin A, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, et al. Cytotoxic effect of a novel naphthylchalcone against multiple cancer cells focusing on hematologic malignancies. Biochim. 2017; 140:48-57.
You can view some of Dr Natália’s work below and links to her professional profile below.
Research Gate: https://www.researchgate.net/profile/Natalia-Stephanes
Linkedin: https://www.linkedin.com/in/nataliamarceli/
Can you refrigerate Barium Sulfate suspension?
Yes, you can refrigerate Barium Sulfate suspension. Refrigeration can extend the shelf life and maintain the stability of the suspension.
It is essential to store the suspension in a tightly sealed container and keep it refrigerated but avoid freezing the suspension. Follow any specific storage instructions provided by the manufacturer or healthcare professional.
Refrigerating Barium Sulfate suspension helps to slow down any potential degradation or settling of the particles, ensuring that the suspension remains homogeneous and effective for a longer period.
This can be particularly important in healthcare settings where the suspension must be prepared in advance or stored for future use.
When appropriately refrigerated, the suspension maintains its desired consistency and uniformity, allowing for consistent results and accurate imaging during medical procedures. However, it is crucial to note that the suspension should be inspected before use.
If any signs of discolouration, clumping, or unusual texture are observed, it should not be used and instead be replaced with a fresh preparation.
What are the standard storage conditions for Barium Sulfate suspension?
The standard storage conditions for Barium Sulfate suspension typically involve keeping it in a cool and dry place. It is recommended to store the suspension in a tightly sealed container at room temperature, away from direct sunlight, moisture, and excessive heat.
The ideal temperature range for storage is usually between 20°C and 25°C (68°F and 77°F). (1)
It is essential to avoid freezing the suspension, as this can potentially alter its properties and affect its effectiveness during medical imaging procedures. Referegation of most suspensions results in increased shelf life, For example, Keflex suspension when refrigerated, lasts longer.
Additionally, it is necessary to follow any specific storage instructions provided by the manufacturer or healthcare professional, as they may have specific recommendations based on the formulation and stability of the particular Barium Sulfate suspension being used.
Storage precautions for Barium Sulfate:
While handling and storing the refrigerated Barium Sulfate suspension, it is important to take certain precautions to ensure safety and maintain the quality of the suspension. Here are some specific precautions to consider:
- Ensure proper labelling: Clearly label the container with the name of the suspension, the date of preparation, and any other relevant information. This helps to avoid confusion and ensures proper identification.
- Securely seal the container: Ensure that the container is tightly sealed to prevent any leakage or contamination. This helps maintain the suspension’s integrity and prevents any potential exposure to air or moisture.
- Separate from food items: Store the Barium Sulfate suspension separately to prevent accidental ingestion. This helps avoid potential health risks and ensures the suspension remains only for medical purposes.
- Keep away from children and pets: Store the refrigerated suspension in a location that is inaccessible to children and pets. This minimizes the risk of accidental ingestion and ensures their safety.
- Follow storage temperature guidelines: Maintain the recommended temperature range of 2°C to 8°C (36°F to 46°F) while refrigerating the suspension. Fluctuations in temperature can affect the stability and efficacy of the suspension.
- Regularly inspect the suspension: Before using the refrigerated Barium Sulfate suspension, visually check it for any signs of discolouration, clumping, or unusual texture. If any abnormalities are observed, do not use the suspension and seek guidance from a healthcare professional.
- Follow disposal guidelines: Dispose of any unused or expired Barium Sulfate suspension properly according to local regulations and guidelines. Consult with local authorities or healthcare professionals for appropriate disposal methods.
By following these precautions, you can help ensure the refrigerated Barium Sulfate suspension’s safety, efficacy, and quality throughout its storage and handling.
How do you know Barium Sulfate has gone bad?
Certain signs can indicate that the refrigerated Barium Sulfate suspension has gone bad and should not be used. It is important to inspect the suspension before use and look out for the following signs: (1)
- Colour changes: If the suspension has developed an unusual or significantly different colour, such as discolouration or darkening, it may indicate degradation or contamination. In such cases, the suspension should not be used.
- Clumping or settling: If the particles of the Barium Sulfate suspension have clumped together or settled at the bottom of the container, it suggests a loss of homogeneity. Shake the container gently; if the suspension does not mix evenly, it may have deteriorated and should not be used.
- Unusual odour or smell: If the suspension emits a foul or abnormal odour, it may indicate bacterial growth or chemical changes. A strong or unpleasant smell indicates that the suspension has likely gone bad and should be discarded.
- Texture changes: Any significant changes in the texture or consistency of the suspension, such as the presence of lumps, gel-like formations, or a gritty texture, may indicate spoilage or contamination. In such cases, the suspension should not be used.
It is important to note that if any of these signs are observed, it is best to proceed on caution and avoid using the refrigerated Barium Sulfate suspension. Consultation with a healthcare professional or the manufacturer is recommended to determine if a replacement is needed.
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References
1.-
Barium Sulfate (National Library of Medicine, NIH)
