Can you drink Fresca with blood pressure medications? 

Can you drink Fresca with blood pressure medications?

You can drink Fresca while you’re on blood pressure meds, but it’s not recommended to take both of them at the same time. It is also not recommended to use Fresca excessively because of the potential side effects. 

Fresca has grapefruit in it, which may interact with some of the blood pressure meds, mainly with the mechanism through which these meds are eliminated (1). As a result, the amount of the drug increases in your body, which could lead to toxicity. 

However, not all antihypertensives react with grapefruit this way. Calcium channel blockers including Nifedipine and Falodipine are known to react with grapefruit in terms of drug absorption and metabolism (2). 

Make sure you talk to your healthcare provider if you’re a chronic user of antihypertensive meds or if your blood pressure is unmanaged currently. 

Potential risks of drinking Fresca with blood pressure medications

Drinking Fresca with blood pressure medications is associated with some potential risks, including:

Potassium levels

Fresca contains potassium citrate, which is a form of potassium. Some blood pressure medications, such as ACE inhibitors and potassium-sparing diuretics, can increase potassium levels in the body. 

Consuming Fresca, which also contains potassium, may lead to excessive potassium levels when combined with these medications, posing a risk of hyperkalemia (high potassium levels). (3)

Aspartame sensitivity

Fresca contains aspartame, an artificial sweetener. While rare, some individuals may have sensitivities or reactions to aspartame. 

If you are taking blood pressure medication, combining it with Fresca may potentially exacerbate any adverse effects or interactions associated with aspartame (4).

Individual reactions

Each person’s response to certain ingredients can vary. Some individuals may experience increased blood pressure or adverse effects due to specific components present in Fresca, such as citric acid or natural flavours. 

To ensure the safe use of blood pressure medication and minimize any potential risks, it is important to consult with your healthcare provider or pharmacist. 

Final words

To sum up, you shouldn’t combine Fresca and blood pressure medications. The intensity of the drug-beverage interaction depends on the type of antihypertensive drug you are taking. This is why it’s best to reach out to your doctor and pharmacist before combining anything with your blood pressure medication. 

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Grapefruit and drug interactions. Prescrire Int. 2012 Dec;21(133):294-5, 297-8. PMID: 23373097. Available from:


Harvard Health Publishing. Grapefruit and medication: A cautionary note [Internet]. Available from:


Simon LV, Hashmi MF, Farrell MW. Hyperkalemia. 2023 Feb 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29261936.


Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Courts FL, Pechlivanis A, Gooderham NJ, Holmes E, le Roux CW, Atkin SL. Aspartame sensitivity? A double blind randomised crossover study. PLoS One. 2015 Mar 18;10(3):e0116212. doi: 10.1371/journal.pone.0116212. Erratum in: PLoS One. 2015;10(5):e0126039. PMID: 25786106; PMCID: PMC4364783.