Can Suboxone make me tired? 

Can Suboxone make me tired? 

Suboxone may or may not make you feel tired. It’s not common in every individual, but Suboxone can cause tiredness or fatigue in some cases, especially during the early course of the treatment. 

This usually happens when your body is trying to adjust to the medication. Once it is completely adjusted to the effects of Suboxone, tiredness will no longer be a side effect. 

This is why most healthcare providers recommend not engaging in any activity that requires your full mental alertness as long as you don’t know how the medication makes you feel. 

Once you have taken it a couple of times and you know what side effects are common in your case, you can adjust the timing accordingly. 

Why does Suboxone cause tiredness? 

Suboxone is a partial opioid agonist and is used to treat opioid addiction and manage the withdrawal symptoms associated with it (1). Suboxone also binds to opioid receptors in your brain but it’s not as strong as Opioids and does not cause addiction or other harmful side effects. 

This is why the medication can make you feel a little tired and drowsy during the first few days of your treatment. 

Clinical studies on Suboxone and tiredness

Tiredness or fatigue is a common side effect of Suboxone use. According to a study published in the journal Drug and Alcohol Dependence, fatigue was reported by 19.3% of participants who were treated with Suboxone for opioid dependence (2). 

Another study published in the Journal of Addiction Medicine found that fatigue was reported by 17.2% of participants taking Suboxone (3).

If fatigue is a persistent or concerning side effect of Suboxone use, it is important to discuss this with a healthcare professional. In some cases, the doctor may adjust the dose or switch to another medication. Suboxone may also cause weight changes by reducing activity and energy levels in some cases.

Should you be concerned about Suboxone-induced tiredness? 

If you’re a new Suboxone user, you shouldn’t worry too much about feeling tired or drowsy. 

Although it is not a common side effect, people do respond to medications differently and side effects can vary with differences in age, weight, dose strength, the severity of symptoms, and overall physiological functioning. 

So if you’re feeling tired but someone else who’s also taking the drug doesn’t feel that way, don’t worry or think you’re being unusually affected by the drug. Just hold on to it and be patient. 

Your tiredness will eventually subside once your body adjusts to the medication. However, if you continue to feel this way or if your tiredness increases, talk to your healthcare provider right away. 

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Buprenorphine and naloxone (oromucosal/sublingual route) – Drugs and Supplements – Mayo Clinic [Internet]. [updated 2021 Jul 1; cited 2023 Jan 5]. Available from:


Eibl JK, Gauthier G, Pellegrini D, Daiter J, Varenbut M, Hogenbirk JC. The effectiveness of telemedicine-delivered opioid agonist therapy in a supervised clinical setting. Drug Alcohol Depend. 2017;176:133-138. doi:10.1016/j.drugalcdep.2017.02.013


Arfken CL, Johanson CE, di Menza S, Schuster CR. Expanding treatment capacity for opioid dependence with office-based treatment with buprenorphine: National survey of physicians. J Addict Med. 2010;4(2):81-86. doi:10.1097/ADM.0b013e3181c8166b