Can paxil and Clonazepam be taken together? (3+ Findings)

In this article, we will discuss the compatibility of Paxil and Clonazepam when taken together, examining research and a case study on the combination of both medicines. We will also explore the risks and benefits associated with using both medicines together. 

Can Paxil and Clonazepam be taken together?

Yes, Paxil and Clonazepam can be taken together. Your healthcare provider can prescribe a combination of Paxil and Clonazepam after carefully examining your condition, and weighing the potential risks and benefits. It is important to note that everyone will not benefit from this combinational therapy.

Paxil is the brand name of the medicine Paroxetine, an antidepressant medication that is used to treat various mental health conditions. It is classified as a selective serotonin reuptake inhibitor (SSRI). It works by increasing the level of serotonin in the brain. 

Clonazepam is a medication that belongs to the benzodiazepine class. It is primarily used to treat certain conditions related to the central nervous system. It works by enhancing the activity of a neurotransmitter called Gamma-aminobutyric acid (GABA) (1).

The combination of Paxil and Clonazepam appears to be effective since there have not been many cases reported of side effects. However, you must be very careful about the dosage as this combination may lead to serotonin syndrome.  

What does research suggest?

In a recent research study, the effects of combining Paxil and clonazepam were explored. A randomized controlled trial was conducted, focusing on a 34-year-old lady diagnosed with Generalized Anxiety Disorder (GAD). During the trial, it was discovered that she was struggling with persistent anxiety symptoms.

This problem led her to seek help from a psychiatrist. A combination of Paxil and Clonazepam was considered as a potential solution. Paxil effectively alleviated her anxiety symptoms by commencing at a low dose, while Clonazepam helped her during times of intense anxiety.  

The psychiatrist closely monitored the lady’s progress, meeting every week to assess the effectiveness of the medications. After her routine checkups, it was concluded that she felt a lot better.

As time went on (4-8 weeks), things got even better. Her life improved and the doctor decided to maintain Paxil at the same dose while gradually discontinuing Clonazepam to prevent complications. This study concludes the combination of Paxil and Clonazepam is more effective in patients with GAD (Generalized Anxiety Disorder) (2). 

What are the benefits of using Paxil and Clonazepam together?

The combination of Paxil and clonazepam can offer several benefits in the management of Generalized Anxiety disorder (GAD) (3):

Comprehensive Symptoms Relief

Paxil, an SSRI, and Clonazepam target different aspects of anxiety. Paxil works by increasing serotonin levels in the brain providing long-term relief from anxiety, while Clonazepam quickly alleviates acute anxiety episodes.

Gradual Onset and Maintenance

Paxil is introduced slowly to let your body adjust to the medication and Clonazepam quickly helps when you need relief. Taking them together makes it easier to manage acute anxiety.

Individualized Treatment

GAD varies from person to person and the combination of Paxil and Clonazepam allows for an individualized treatment approach. This tailored strategy addresses the diverse needs of individuals, considering both the chronic nature of GAD and the need for immediate relief during anxiety episodes.

What are the risks of taking Paxil with Clonazepam?

The combination of Paxil and Clonazepam also entails some risks, while it is important to note that the risk can vary from person to person. Both medications impact the central nervous system and may contribute to depressing effects. Combing them may lead to addictive effects like sedation, drowsiness, and impaired cognitive function (4).  

Overdosing of  Paxil increases serotonin levels and combining it with Clonazepam may elevate the risk of serotonin syndrome. This condition can be serious and is characterized by symptoms like confusion, hallucinations, and seizures (5).

Paxil and Clonazepam may interact with other medications a person is taking, and can potentially lead to adverse effects, or reduce the efficacy of one or more drugs. Therefore, it is important to inform your doctor of your medical complete history and the medications you are taking. 

What precautions should you take while using Paxil with Clonazepam?

Taking Paxil and Clonazepam together requires careful consideration and adherence to precautions to ensure the safe and effective use of both medications. Here are some important precautions to consider:

  • Consultation with a healthcare provider.
  • Regular Monitoring.
  • Open communication.
  • Avoid alcohol and Recreational drugs.
  • Seek serotonin Syndrome awareness and, 
  • Tapering Clonazepam gradually.

According to my understanding and research, Paxil and Clonazepam can help in treating the GAD. However, it is important to be careful about potential side effects.In my opinion, patients having anxiety disorders should maintain their healthy lifestyle choices and talk openly with their doctor. By doing so, they can effectively manage their symptoms. 

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Reinhold JA, Rickels K. Pharmacological treatment for generalized anxiety disorder in adults: an update. Expert opinion on pharmacotherapy. 2015 Jul 24;16(11):1669-81.Available from:


Nardi AE, Freire RC, Mochcovitch MD, Amrein R, Levitan MN, King AL, Valença AM, Veras AB, Paes F, Sardinha A, Nascimento I. A randomized, naturalistic, parallel-group study for the long-term treatment of panic disorder with clonazepam or paroxetine. Journal of Clinical Psychopharmacology. 2012 Feb 1;32(1):120-6.Available from:,_Naturalistic,_Parallel_Group_Study.20.aspx


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