Can Luvox be taken with Effexor? (+3 tips)

In this article, we will discuss whether Luvox (Fluvoxamine) can be taken with Effexor (Venlafaxine). We will also discuss some research studies and how to ensure the safe use of these medications together.

Can Luvox be taken with Effexor?

Luvox (Fluvoxamine) can be taken with Effexor (Venlafaxine) but only under the guidance of a healthcare professional.  Both Luvox and Effexor are prescription medications and should be used when prescribed by a healthcare professional. 

Luvox and Effexor are both antidepressant medications. They both work on chemicals in your brain and balance them to help your symptoms. Both antidepressants affect serotonin levels in the brain (1,2)

Combining the medication that affects serotonin increases the risk of a rare but serious condition called serotonin syndrome.

If your doctor has prescribed both medications together, they likely consider the potential risks and benefits and will monitor you closely for any signs of serotonin syndrome and other side effects.

Always consult your healthcare provider regarding medication combinations to ensure your safety.

When can Luvox be taken with Effexor?

The combination of Luvox and Effexor might be considered in specific cases of treatment-resistant depression and anxiety disorders. However, combining these medications should only be done under the guidance and supervision of a healthcare professional. They can monitor for side effects and adjust the treatment accordingly.

Always remember individual responses to medications vary and if an individual is not responding well to single-drug treatment then a combination of medications could be useful in alleviating the symptoms. However, these medications should be taken under medical supervision to ensure safety and efficacy.

What does research suggest?

Several research studies indicating the combined use of SSRIs such as Fluvoxamine and SNRIs such as Venlafaxine have been reported.

One study indicated cases in which people taking Venlafaxine alone did not fully recover from depression, adding a different class of antidepressant SSRI (Sertraline, Fluvoxamine, etc) helped (1).

These individuals had tried different antidepressants before without full success. When they combined an SSRI with Venlafaxine, they got better without major side effects (1).

The study reported a case in which Mrs D had a history of OCD, especially before her periods. She tried various medicines but her symptoms recovered by nearly 50% when she started taking Venlafaxine. Despite trying higher doses of Venlafaxine, Mrs D symptoms did not improve any further (1).

The doctor recommended adding SSRI to her Venlafaxine treatment. She then noticed her OCD symptoms reduced to 85%. Her family noticed a big positive change (1).

Another study also explained that the reason behind combining SSRIs with Venlafaxine is to increase the impact on serotonin in the brain by using both medications and also to affect other receptors related to adrenaline (2).

The advantage comes from boosting the overall effect of SSRIs; at lower doses, Venlafaxine acts more like an SSRI (2).

What are the advantages of using Fluvoxamine and Effexor together?

Fluvoxamine and Effexor can be prescribed for managing treatment-resistant depression or anxiety disorders. Some potential benefits include:

Increased effectiveness: Combined use of medications that work on different neurotransmitters such as serotonin and norepinephrine can result in increased effectiveness against depression and anxiety symptoms.

Resistant cases: In some situations, single-drug treatment is not effective in alleviating the symptoms of anxiety and depression. Combining two different classes of antidepressants results in the relief of symptoms for individuals who do not respond well to single-drug treatment (3).

It is important to note that the combination of antidepressants should only be used under the close supervision of a healthcare professional.

What are the side effects of Fluvoxamine and Effexor together?

A combination of Fluvoxamine and Effexor is associated with certain side effects. These include:

Serotonin syndrome: Combined use of Fluvoxamine and Effexor results in an increased concentration of serotonin in the brain which results in a life-threatening condition known as serotonin syndrome characterized by symptoms such as agitation, hallucinations, increased heart rate, seizures etc (5).

Serotonergic side effects: Both these medications affect serotonin in the brain and are also associated with side effects such as nausea, insomnia, dizziness, etc. When taken together these side effects are intensified.

Cardiovascular side effects: Cardiovascular side effects are intensified by the combined use of these medications.

These side effects can vary from person to person. Some people may get worse at this combination. If your doctor has prescribed you this combination, keep a close eye on your side effects. If you suspect that your side effects are getting worse, report it to your healthcare provider straight away.

It is essential to use this medication combination only under the close supervision of a healthcare provider who can monitor your response and adjust your treatment as needed.

How to ensure the safe use of Fluvoxamine and Effexor together?

The following points should be kept in mind to ensure the safe and effective use of Fluvoxamine and Effexor together.

  • Always take these medications as prescribed by your healthcare provider.
  • Effexor can be taken at any time of the day when used alone. However, your doctor may ask you to take these medications at different times to minimize the risk of potential side effects.
  • Take the medications at the same time each day to ensure a uniform concentration of drugs in your body.
  • Do not skip the doses or discontinue your medication without consulting your doctor as it can cause horrible withdrawal symptoms (6).
  • Avoid the consumption of alcohol or caffeine with antidepressants as it can intensify the side effects.


In my view, combining Luvox and Effexor should be approached cautiously and only under the guidance of a healthcare professional due to increased risk of side effects, including the potential for serotoin syndrome. Always consult your doctor before using this combination.





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