Can Januvia be cut in half? 

Can Januvia be cut in half? 

No, Januvia (Sitagliptin) should not be crushed, cut, or chewed. The tablets should be swallowed whole. It actually comes with a warning from the manufacturer for not cutting or crushing the tablets. 

The exact reason why the manufacturer has recommended it is not fully explained, but the way these meds are formulated is probably the reason why cutting them could affect the stability of the drug. 

Risks associated with cutting Januvia in half

Januvia is available as film-coated tablets and this coating could be the reason why you shouldn’t cut them. The coating on the tablets helps in a number of ways. It protects the active drug from stomach acids to some extent and can also help mask the unpleasant taste of the drug(1)

Film coating also prevents moisture from penetrating the tablets, which may trigger the degradation processes. So, it’s best not to cut these tablets and swallow them whole. 

Alternatives to cutting Januvia

Talk to your doctor or pharmacist if you find it difficult to swallow the Januvia tablets or if your dose is changed. If your doctor has decreased your dose and you still have some tablets left-over from your last prescription, don’t cut them in half. Instead, get a new prescription. 

Januvia is available in 25, 50, and 100 mg tablets. It’s best to ask your doctor for an alternative rather than secretly cutting your tablets. It won’t benefit you and there’s no guarantee from the manufacturer regarding the safety of split tablets.

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PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 4369359, Sitagliptin. Available from: