Can you take Methylprednisolone and alcohol together? 

Methylprednisolone is a corticosteroid that can lead to several side effects, particularly in long-term users, and alcohol may exacerbate some of these side effects. 

Understanding the risks associated with combining Methylprednisolone and alcohol is crucial for patients to make informed decisions regarding their health and treatment.

Can you take Methylprednisolone and alcohol together? 

You can occasionally drink alcohol while you’re being treated with methylprednisolone, but not without consulting your healthcare provider first. This is because alcohol and Methylprednisolone may share some of the side effects so they at the same time may increase those side effects. 

Methylprednisolone is a corticosteroid associated with several side effects, which are more common among long-term users of this medication (1). Alcohol, on the other hand, isn’t your friend either.

What are the risks of combining Methylprednisolone with alcohol?

The following are the risks associated with combing Methylprednisolone with alcohol:

Risk of gastrointestinal bleeding

Both alcohol and Methylprednisolone have the potential to irritate and harm the digestive system. When used together, they increase the likelihood of gastrointestinal bleeding, as well as the risk of stomach ulcers and other digestive issues (2).

Increased drowsiness

The central nervous system can be affected by both Methylprednisolone and alcohol. They may intensify each other’s sedative effects when taken combined, resulting in increased drowsiness, decreased coordination, and decreased cognitive performance (3).

Increased risk of liver damage

The liver plays a vital role in metabolizing Methylprednisolone, and consuming alcohol can have detrimental effects on the liver. When alcohol and Methylprednisolone are combined, there is an increased risk of liver damage, especially for individuals with pre-existing liver conditions (4).

Risk of a compromised immune system

Methylprednisolone is an immunosuppressive drug, which means it can weaken the immune system. Additionally, alcohol consumption can also have a suppressive effect on the immune system. 

When alcohol is combined with methylprednisolone, it may further compromise the immune system, increasing the risk of infections and other health issues (5).

Insufficient therapeutic activity of Methylprednisolone

Methylprednisolone is prescribed for a number of medical diseases, such as autoimmune and inflammatory illnesses. Alcohol use may worsen these problems and may work against Methylprednisolone’s therapeutic benefits.

What are the safety considerations and recommendations? 

It is better to talk to your doctor about drinking alcohol while taking Methylprednisolone. In usual practice, an occasional drink on a weekend or at a party may not harm you. It’s the consistent and excessive use of alcohol that can affect your health and cause disturbing complications. 

If your doctor approves of drinking alcohol while taking Methylprednisolone, make sure you avoid taking them at the same time. It is also important to note that the use of alcohol with Methylprednisolone depends on the individual’s condition and his/her overall health status.

There are other things that should be avoided while taking Methylprednisolone, including certain medications and beverages. Always remember, the safe and effective use of drugs is the key to achieving the most out of them.


The combination of Methylprednisolone and alcohol entails several risks that individuals should be aware of to safeguard their well-being. Such risks include an increased potential for gastrointestinal bleeding and liver damage, as well as heightened drowsiness and compromised immune system function. 

It is recommended to discuss alcohol consumption with a healthcare provider while taking Methylprednisolone, and if approved, to avoid taking them simultaneously. 

Patients should be mindful of other medications and beverages to be avoided while on Methylprednisolone and prioritize the safe and effective use of their medications to maximize therapeutic benefits.

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Narum S, Westergren T, Klemp M. Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis. BMJ Open [Internet]. 2014 May;4(5):e004587.


Arthritis Foundation. Alcohol and Arthritis. [Website].


Warrington TP, Bostwick JM. Psychiatric Adverse Effects of Corticosteroids. Mayo Clinic Proceedings. 2006 Oct;81(10):1361–7.


Warrington TP, Bostwick JM. Psychiatric Adverse Effects of Corticosteroids. Mayo Clinic Proceedings. 2006 Oct;81(10):1361–7.


Karakike E. Infections in severe alcoholic hepatitis. Annals of Gastroenterology. 2016