Can you take Diclofenac and Cyclobenzaprine together? 

Can you take Diclofenac and Cyclobenzaprine together?

Yes, you can take Diclofenac and Cyclobenzaprine together. The two meds do not necessarily interact with one another. They have different mechanisms of action and cause different types of side effects, so you can take these meds together. 

However, it’s best to take them at separate times to minimise even the mildest of interactions in some people. The doses of these medications should also be adjusted, as high doses have more potential for interaction and they may remain longer in your body. 

As long as these two meds are taken properly, they shouldn’t cause unwanted adverse events. Cyclobenzaprine can also be taken with other NSAIDs, like Aspirin. However, people are different and they respond differently to medications. It is best to ask your doctor if you can safely use this combination or not. 

What are the possible side effects of taking Diclofenac and Cyclobenzaprine together? 

Diclofenac and Cyclobenzaprine may cause some side effects, mostly gastrointestinal in nature(12). These meds are generally well tolerated and not too many side effects are expected, but they may cause the following side effects:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Upset stomach
  • Acid reflux
  • Dry mouth
  • Fatigue 

The side effects are usually mild and they may get better as your treatment continues. However, a small number of people could be allergic to either one or both of these medications. 

If you find yourself feeling unusual after taking either of the medications, immediately seek medical attention. 

Precautions and warnings when taking Diclofenac and Cyclobenzaprine together

There are some important precautions and warnings before you take this combination. The important points include:

  • Do not take the combination of Diclofenac and Cyclobenzaprine without consulting your doctor or pharmacist first.
  • Diclofenac and Cyclobenzaprine can interact with other medications, including over-the-counter medications, herbal supplements, and vitamins. Inform your doctor or pharmacist of all medications and supplements you are taking before taking Diclofenac and Cyclobenzaprine together.
  • Do not take this combination if you are allergic to either one of these meds.
  • Diclofenac can increase the risk of heart attack or stroke, especially if taken for long periods or in high doses. Cyclobenzaprine can also affect the heart, particularly in people with pre-existing heart conditions. Inform your doctor if you have any history of heart disease before taking Diclofenac and Cyclobenzaprine together.
  • Both of these meds can cause ulceration or can exacerbate the symptoms associated with pre-existing gastric ulcers. Make sure you inform your doctor if you already have a GI illness – as this combination may not be tolerable for such people.
  • Inform your doctor if you are pregnant or breastfeeding before taking Diclofenac and Cyclobenzaprine together, as they can affect fetal development and milk production.
  • Do not stop taking Diclofenac or Cyclobenzaprine without consulting your doctor, as sudden withdrawal can cause withdrawal symptoms or other adverse effects.

What to do if you can’t tolerate Diclofenac and Cyclobenzaprine? 

If for some reason, you can’t tolerate taking Diclofenac and Cyclobenzaprine on the same day, talk to your healthcare provider. 

Although it is quite rare, some people may still not do well on these meds. In such a case, it’s always best to discuss the use of these meds with your doctor and their alternatives if you can’t continue taking them. 

There are plenty of other muscle relaxers and painkillers that may suit you better. Just make sure you don’t start taking any medication on your own. 

You should always seek medical advice before switching medications, especially if you are generally sensitive to meds or have a pre-existing medical condition.

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PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3033, Diclofenac; [cited 2023 Mar. 04]. Available from:


PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 2895, Cyclobenzaprine; [cited 2023 Mar. 04]. Available from: