Can Effexor make you jittery? 

Can Effexor make you jittery? 

Effexor can make some people jittery, especially during the early course of their treatment. Jitteriness is not generally considered a common side effect, but it’s common enough to know that Effexor is causing it if you have started using this antidepressant lately. 

People who are sensitive to the stimulation of neurotransmitters are more susceptible to this side effect, or those who are generally anxious and unable to relax. 

Effexor and other antidepressants can also affect your sleep architecture in a number of ways, which can trigger jitteriness in some people. If you’re a new user and feel jittery, you will get better within a few weeks as your body adjusts to the medication. 

What does research suggest?

There is limited research on jitteriness caused by Effexor, as the antidepressant is known to counteract such symptoms, let alone cause them. However, Effexor and related antidepressants can cause jitteriness in the early course of the treatment.

Antidepressants take time to adjust in your body when you start taking them for the very first time or if you switch from one antidepressant to another. 

This is a common thing among antidepressant users and the majority of them experience some early side effects like jitteriness- which may or may not affect their treatment plan (1). Other classes of antidepressants, including SSRIs like Zoloft, Prozac, etc can also cause early anxiety or jitteriness. 

However, Effexor is approved by the Food and Drug Administration for the management and treatment of anxiety disorders which are commonly associated with jitteriness (2). 

Research studies indicate that with time, Effexor balances the amount of two excitatory monoamine neurotransmitters – serotonin and norepinephrine – which start to counteract several symptoms of anxiety and depression and can improve the quality of life (3,4). 

What to do if Effexor makes you jittery? 

It’s best to reach out to your healthcare provider if you feel jittery after taking Effexor. As I discussed in the previous section, it could be an early side effect of this antidepressant and may fade away on its own. 

However, antidepressants affect people differently; not everyone feels better about them. Effexor is generally well tolerated, but some people may fail to adjust to it or tolerate it. 

This is why you should always discuss your side effects with your doctor to determine the future safety and efficacy of Effexor use. Some people just need a dose reduction and they start to do well on a lower dose – but this should be decided by your doctor. 

Make sure you don’t stop using Effexor or change the dose without consulting your doctor first. 

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