Can Effexor cause manic episodes? (+9 factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether Effexor can cause manic episodes. We will also discuss the factors that may influence the occurrence of manic episodes while taking Effexor and the management tips for manic episodes while taking Effexor.
Can Effexor cause manic episodes?
Yes, Effexor can cause manic episodes. Effexor (venlafaxine) has been reported to potentially induce manic episodes, particularly in individuals with bipolar disorder, due to its effects on mood regulation. It’s important to be aware of this risk and consult with a healthcare professional when considering or using this medication.
Venlafaxine is an antidepressant medication. It belongs to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant medications. It is primarily prescribed to manage and treat mental disorders and their associated symptoms including depression, anxiety, and panic disorders. The most common side effects associated with Effexor are nausea, vomiting, weight changes, dizziness headaches, and dry mouth (1).
What does research suggest?
According to research, a young girl, with major depressive disorder, developed manic symptoms after 4 weeks of starting treatment with Effexor. Her condition did not improve even after the discontinuation of Effexor. Valproate was added to her treatment, leading to a reduction in manic symptoms after 8 weeks (2). This case suggests Effexor-induced mania in a patient with no previous bipolar risk factors.
In a research case, a 41-year-old man with a prior history of bipolar disorder was admitted due to severe depression. When treated with Effexor alongside lithium carbonate and valproate for a severe depressive episode, he improved briefly but developed a manic episode six days later. Effexor was discontinued while lithium carbonate and valproate were continued at their usual dosages resulting in the alleviation of manic symptoms (3).
Another study reported a 30-year-old patient with a history of depression. She was taking Effexor daily and her symptoms included ruminative thinking and agitation. She displayed an irritable mood leading to a diagnosis of bipolar disorder characterized by anxiousness and distress (4).
Factors that increase the risk of manic episodes while taking Effexor
Effexor (venlafaxine) can increase the risk of manic episodes, particularly in individuals with underlying bipolar disorder.
Several factors can increase the risk of experiencing manic episodes while taking Effexor, especially in individuals with underlying bipolar disorder. These factors include:
- Underlying bipolar disorder
- History of bipolar disorder
- Family history of mania or bipolar disorder
- Dosage of Effexor
- Rapid Medication Titration
- Alcohol use and substance abuse
- Concurrent Medications
- High-stress levels
- Individual sensitivity to Effexor
It is important to discuss any potential risk factors with your healthcare provider before starting or adjusting your medication regimen. Regular monitoring and open discussion with your healthcare provider are essential in managing the risk of manic episodes while taking Effexor.
What to do if Effexor causes manic episodes?
If you experience manic episodes while taking Effexor, follow these recommendations:
- Consult your healthcare provider if you experience any side effects of Effexor including the appearance of manic episodes. Reach out to your healthcare provider as soon as possible so they can assess your condition and determine the best treatment plan based on your individual needs.
- Do not adjust or discontinue Effexor yourself if you experience any side effects. Your healthcare provider may recommend adjusting or discontinuing Effexor if they find it necessary especially if you have bipolar disorder.
- Your healthcare provider may consider adding a mood stabilizer or alternative medication to manage the manic episodes. However, you should never self-medicate to counteract any side effects of Effexor.
- Pay attention to factors that can contribute to mood stability, such as managing stress, maintaining a regular sleep schedule, and avoiding alcohol or substance use.
- Educate yourself about bipolar disorder and the potential triggers for manic episodes. This knowledge can empower you to manage your condition more effectively.
Remember that working closely with your healthcare provider to tailor your treatment plan to your specific needs is crucial. Manic episodes can be serious, and professional guidance is essential to ensure your safety and well-being.
Conclusion
In conclusion, based on my knowledge and experience, Effexor can trigger manic episodes, particularly in individuals with a history of bipolar disorder. Close monitoring is important when prescribing Effexor to at-risk patients.
While Effexor is beneficial for treating depression and anxiety, its potential to induce mania underscores the importance of individualized treatment and careful consideration of its risks. Balancing these factors is crucial for effective mental health management and patient safety.
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References
1.-
Singh D, Saadabadi A. Venlafaxine. [Updated 2022 Oct 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535363/
2.-
Raman RP, Math SB, Gangadhar BN. Venlafaxine-induced manic switch in an adolescent patient: a case report. Prim Care Companion J Clin Psychiatry. 2007;9(6):470. doi: 10.4088/pcc.v09n0611g. PMID: 18185834; PMCID: PMC2139924. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139924/
3.-
Christophe Liberek, Jean-Michel Aubry, Patrick Baud, Manic Switch and Serotonin Syndrome with Venlafaxine-Lithium-Valproate Association: État maniaque et syndrome sérotoninergique avec une association venlafaxine-lithium-valproate,
Therapies,Volume 61, Issue 6,2006,Pages 531-533,ISSN 0040-5957,https://doi.org/10.2515/therapie:2006075.(https://www.sciencedirect.com/science/article/pii/S0040595716304243)
4.-
Yıldızhan E, Ünlü Çilesiz M, Ekici E, Tomruk N. A Case of Ruminative Hypomania Induced by High Dose Venlafaxine. European Psychiatry. Cambridge University Press; 2022;65(S1):S414–S415. https://www.cambridge.org/core/journals/european-psychiatry/article/case-of-ruminative-hypomania-induced-by-high-dose-venlafaxine/F5AE33D5087A52FA6EC44DCACFD3E75B
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