Can Acyclovir be crushed? 

Can Acyclovir be crushed? 

You can crush Acyclovir and mix it with soft foods like applesauce or pudding if you find it difficult to swallow the tablets whole. According to NHS, you can dissolve Acyclovir tablets in some water and drink it if you can’t swallow the tablets(1)

However, it’s best to talk to your healthcare provider before you decide to crush the tablets, as it’s an antiviral medication and proper use is essential for reducing the viral load. 

Risks associated with crushing Acyclovir tablets

Tablet crushing is frowned upon for a number of reasons and not everyone can do that in the right way. If doing so, you need to make sure that you take the entire tablet and leave nothing behind. 

If you leave the powder stuck to the container you added it into, you will end up taking less than your doctor’s prescribed dose. Proper dose administration is necessary when you have an active viral infection in your body. 

The crushed tablets may taste extremely bitter and unpleasant. You can add it to soft foods like applesauce or pudding to help mask the unpleasant taste of the drug. 

Do not crush Acyclovir intended for the buccal route

Acyclovir is also formulated into buccal tablets which are supposed to be placed on cold sores present inside your mouth – like your gums(2). You should not chew, crush, or swallow these pills, as they provide a local antiviral effect and kill the dividing virus in the infected area. 

Crushing or swallowing it will result in zero therapeutic response. If you’re not sure whether you have an oral Acyclovir or buccal Acyclovir, talk to your doctor or pharmacist. 

Acyclovir should be used properly to achieve your desired antiviral effects. Make sure you are using Acyclovir according to your doctor’s recommendations and that your medication is fully potent to help you with your symptoms.

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The Food and Drug Administration. Acyclovir prescribing information [Internet]. Silver Spring (MD): The Food and Drug Administration; 2021 [cited 2021 Sep 13]. Available from:


Mayo Clinic. Acyclovir (buccal mucosa route) [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; c2021. Available from: